Actinomycin lactonase

Class of enzymes

actinomycin lactonase

Identifiers
EC no.| 3.1.1.39
CAS no.| 37288-09-8
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
| Search

PMC| articles
PubMed| articles
NCBI| proteins

The enzyme actinomycin lactonase (EC 3.1.1.39) catalyzes the reaction

actinomycin + H2O  ⇌ {\displaystyle \rightleftharpoons } actinomycinic monolactone

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is actinomycin lactonohydrolase.

## References

[edit]

* Hou CT, Perlman D (1970). "Microbial transformations of peptide antibiotics. V. Purification and properties of the actinomycin lactonase from Actinoplanes missouriensis". J. Biol. Chem. 245 (6): 1289–95\. PMID 4191854.1289-95&rft.date=1970&rft_id=info:pmid/4191854&rft.aulast=Hou&rft.aufirst=CT&rft.au=Perlman,+D&rfr_id=info:sid/en.wikipedia.org:Actinomycin+lactonase" class="Z3988">

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Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases|

* Cholinesterase
* Acetylcholinesterase
* Butyrylcholinesterase
* Pectinesterase
* 6-phosphogluconolactonase
* PAF acetylhydrolase

* Lipase
* Bile salt-dependent
* Gastric/Lingual
* Pancreatic
* Lysosomal
* Hormone-sensitive
* Endothelial
* Hepatic
* Lipoprotein
* Monoacylglycerol
* Diacylglycerol

* Phospholipase
* A1
* A2
* B

* Cutinase
* PETase

3.1.2: Thioesterase|

* Palmitoyl protein thioesterase
* Ubiquitin carboxy-terminal hydrolase L1
* 4-hydroxybenzoyl-CoA thioesterase

3.1.3: Phosphatase|

* Alkaline phosphatase
* ALPI
* ALPL
* ALPP
* Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases
* Nucleotidase
* Glucose 6-phosphatase
* Fructose 1,6-bisphosphatase
* Calcineurin
* Protein phosphatase
* PP2A
* OCRL
* Pyruvate dehydrogenase phosphatase
* Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
* PTEN
* Phytase
* Beta-propeller phytase
* Inositol-phosphate phosphatase
* IMPA1, IMPA2, IMPA3
* Protein phosphatase: Protein tyrosine phosphatase
* Protein serine/threonine phosphatase
* Dual-specificity phosphatase

3.1.4:
Phosphodiesterase|

* Autotaxin
* Phospholipase
* C
* D
* Sphingomyelin phosphodiesterase
* 1
* PDE1
* PDE2
* PDE3
* PDE4A/PDE4B
* PDE5
* Lecithinase (Clostridium perfringens alpha toxin)
* Cyclic nucleotide phosphodiesterase

3.1.6: Sulfatase|

* arylsulfatase
* Arylsulfatase A
* Arylsulfatase B
* Arylsulfatase L
* Steroid sulfatase
* Galactosamine-6 sulfatase
* Iduronate-2-sulfatase
* N-acetylglucosamine-6-sulfatase

Nuclease (includes
deoxyribonuclease
and ribonuclease)|

| 3.1.11-16:
Exonuclease|

| Exodeoxyribonuclease|

* RecBCD

|

Exoribonuclease|

* Oligonucleotidase

3.1.21-31:
Endonuclease|

| Endodeoxyribonuclease|

* Deoxyribonuclease I
* Deoxyribonuclease II
* Deoxyribonuclease IV
* Restriction enzyme;see {{Restriction enzyme}}
* UvrABC endonuclease

|

Endoribonuclease|

* RNase III
* Drosha: Microprocessor complex
* Dicer: RNA-induced silencing complex
* RNase H
* 1
* 2A
* 2B
* 2C
* RNase P
* RNase A
* RNase Z
* RNase E
* 1
* 2
* 3
* 4/5
* RNase T1

either deoxy- or ribo-  |

* Nuclease S1
* Mung bean nuclease
* Serratia marcescens nuclease
* Micrococcal nuclease

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

Portal:

* Biology

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