Adiponectin receptor 2

Protein-coding gene in the species Homo sapiens

ADIPOR2

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

3WXW

Identifiers
Aliases| ADIPOR2, adiponectin receptor 2, ACDCR2, PAQR2
External IDs| OMIM: 607946; MGI: 93830; HomoloGene: 56119; GeneCards: ADIPOR2; OMA:ADIPOR2 - orthologs
| Gene location (Human)

Chr.| Chromosome 12 (human)[1]

Band| 12p13.33| Start| 1,688,574 bp[1]
End| 1,788,674 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 6 (mouse)[2]

Band| 6 F1|6 56.78 cM| Start| 119,330,111 bp[2]
End| 119,394,665 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* corpus callosum

* C1 segment

* right adrenal cortex

* right lung

* left adrenal gland

* left adrenal cortex

* substantia nigra

* liver

* epithelium of colon

* hippocampus proper

| Top expressed in

* lactiferous gland

* brown adipose tissue

* transitional epithelium of urinary bladder

* vestibular membrane of cochlear duct

* epithelium of small intestine

* epithelium of stomach

* pyloric antrum

* left lobe of liver

* white adipose tissue

* tunica adventitia of aorta

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* adipokinetic hormone receptor activity
* adiponectin binding
* metal ion binding
* identical protein binding
* protein heterodimerization activity
* signaling receptor activity

Cellular component|

* integral component of membrane
* membrane
* intrinsic component of plasma membrane
* plasma membrane

Biological process|

* positive regulation of glucose import
* glucose homeostasis
* response to nutrient
* lipid metabolism
* female pregnancy
* adiponectin-activated signaling pathway
* fatty acid metabolic process
* vascular wound healing
* heart development
* negative regulation of cell growth
* fatty acid oxidation
* hormone-mediated signaling pathway
* regulation of fatty acid biosynthetic process
* positive regulation of cold-induced thermogenesis

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

79602

68465

Ensembl| |

ENSG00000006831
ENSG00000285070

ENSMUSG00000030168

UniProt| |

Q86V24

Q8BQS5

RefSeq (mRNA)| |

NM_024551
NM_001375363
NM_001375364
NM_001375365

NM_197985
NM_001355692

RefSeq (protein)| |

NP_078827
NP_001362292
NP_001362293
NP_001362294

NP_932102
NP_001342621

Location (UCSC)| Chr 12: 1.69 – 1.79 Mb| Chr 6: 119.33 – 119.39 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene.[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.[6]

## Structure

[edit]

Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.[5]

## Function

[edit]

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[5] In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.[7]

## Ligands

[edit]

### Agonists

[edit]

#### Peptide

[edit]

* Adiponectin
* ADP-355[8]
* ADP-399[8]

#### Non-peptide

[edit]

* AdipoRon[9]
* Deoxyschizandrin[10]
* Parthenolide[10]
* Syringing[10]
* Taxifoliol[10]

### Antagonists

[edit]

#### Peptide

[edit]

* ADP-400[8]

## See also

[edit]

* Adiponectin receptor
* Adiponectin receptor 1

## References

[edit]

1. ^ a b c ENSG00000285070 GRCh38: Ensembl release 89: ENSG00000006831, ENSG00000285070 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030168 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b c Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.
6. ^ Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.
7. ^ University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016
8. ^ a b c Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. Bibcode:2014FrCh....2...93O. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.
9. ^ Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. Bibcode:2013Natur.503..493O. doi:10.1038/nature12656. PMID 24172895. S2CID 4447039.
10. ^ a b c d Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.

## External links

[edit]

* Human ADIPOR2 genome location and ADIPOR2 gene details page in the UCSC Genome Browser.

* v
* t
* e

Membrane proteins, receptors: cell surface receptors

G protein-coupled receptor|

| Class A|

* Eicosanoid receptor (Prostaglandin receptor)
* Protease-activated receptor
* Neurotransmitter receptor
* Purinergic receptor
* Biogenic amine receptor
* Olfactory receptor

|

Class B|

* Secretin receptor

Class C|

* Metabotropic glutamate receptor

Class D|

* Pheromone receptor

Class E|

* cAMP receptor

Class F|

* Frizzled/smoothened

Ligand-gated ion channel|

* Purinergic receptor

Enzyme-linked receptor|

* Serine/threonine-specific protein kinase
* Receptor tyrosine kinase
* Guanylate cyclase

Other/ungrouped|

* Asialoglycoprotein receptor
* Tumor necrosis factor receptor
* Immunoglobulin superfamily
* N-Acetylglucosamine receptor
* Neuropilins
* Transferrin receptor
* EDAR
* Lipoprotein receptor-related protein
* Progestin and adipoQ receptor

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