Afamin

Protein-coding gene in the species Homo sapiens

AFM

Identifiers
Aliases| AFM, ALB2, ALBA, ALF, afamin
External IDs| OMIM: 104145; MGI: 2429409; HomoloGene: 881; GeneCards: AFM; OMA:AFM - orthologs
| Gene location (Human)

Chr.| Chromosome 4 (human)[1]

Band| 4q13.3| Start| 73,481,745 bp[1]
End| 73,504,001 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 5 (mouse)[2]

Band| 5|5 E1| Start| 90,666,791 bp[2]
End| 90,701,402 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* right lobe of liver

* testicle

* kidney tubule

* human kidney

* glomerulus

* metanephric glomerulus

* tibialis anterior muscle

* renal medulla

* mucosa of ileum

* fundus

| Top expressed in

* left lobe of liver

* human kidney

* right kidney

* proximal straight tubule

* renal pelvis

* fetal liver hematopoietic progenitor cell

* renal calyx

* sexually immature organism

* migratory enteric neural crest cell

* gallbladder

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* vitamin E binding
* protein binding

Cellular component|

* extracellular region
* blood microparticle
* extracellular exosome
* extracellular space

Biological process|

* vitamin transport
* transport
* protein transport
* protein stabilization
* protein transport within extracellular region

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

173

280662

Ensembl| |

ENSG00000079557

ENSMUSG00000029369

UniProt| |

P43652

O89020

RefSeq (mRNA)| |

NM_001133

NM_145146

RefSeq (protein)| |

NP_001124

NP_660128

Location (UCSC)| Chr 4: 73.48 – 73.5 Mb| Chr 5: 90.67 – 90.7 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Afamin is a protein that in humans is encoded by the AFM gene.[5][6]

## Function

[edit]

This gene is a member of the albumin gene family, which comprises four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream.[6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079557 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029369 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM (Aug 1994). "Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family". J Biol Chem. 269 (27): 18149–54\. doi:10.1016/S0021-9258(17)32429-8. PMID 7517938.18149-54&rft.date=1994-08&rft_id=info:doi/10.1016/S0021-9258(17)32429-8&rft_id=info:pmid/7517938&rft.aulast=Lichenstein&rft.aufirst=HS&rft.au=Lyons,+DE&rft.au=Wurfel,+MM&rft.au=Johnson,+DA&rft.au=McGinley,+MD&rft.au=Leidli,+JC&rft.au=Trollinger,+DB&rft.au=Mayer,+JP&rft.au=Wright,+SD&rft.au=Zukowski,+MM&rft_id=https://doi.org/10.1016%2FS0021-9258%2817%2932429-8&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
6. ^ a b "Entrez Gene: AFM afamin".

## External links

[edit]

* Human AFM genome location and AFM gene details page in the UCSC Genome Browser.

## Further reading

[edit]

* Noppe M, Lowenthal A, Karcher D, Gheuens J (1979). "A two-site immunoradiometric assay for the determination of alpha-albumin". J. Immunol. Methods. 27 (1): 75–81\. doi:10.1016/0022-1759(79)90240-0. PMID 37276.75-81&rft.date=1979&rft_id=info:doi/10.1016/0022-1759(79)90240-0&rft_id=info:pmid/37276&rft.aulast=Noppe&rft.aufirst=M&rft.au=Lowenthal,+A&rft.au=Karcher,+D&rft.au=Gheuens,+J&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Hansson E, Rönnbäck L, Lowenthal A, Noppe M (1985). "Primary cultures from defined brain areas; effects of seeding time on cell growth, astroglial content and protein synthesis". Brain Res. 353 (2): 175–85\. doi:10.1016/0165-3806(85)90206-8. PMID 4041902.175-85&rft.date=1985&rft_id=info:doi/10.1016/0165-3806(85)90206-8&rft_id=info:pmid/4041902&rft.aulast=Hansson&rft.aufirst=E&rft.au=Rönnbäck,+L&rft.au=Lowenthal,+A&rft.au=Noppe,+M&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Lowenthal A, Flament-Durand J, Karcher D, Noppe M, Brion JP (1982). "Glial cells identified by anti-alpha-albumin (anti-GFA) in human pineal gland". J. Neurochem. 38 (3): 863–5\. doi:10.1111/j.1471-4159.1982.tb08714.x. PMID 7035619. S2CID 40660858.863-5&rft.date=1982&rft_id=https://api.semanticscholar.org/CorpusID:40660858#id-name=S2CID&rft_id=info:pmid/7035619&rft_id=info:doi/10.1111/j.1471-4159.1982.tb08714.x&rft.aulast=Lowenthal&rft.aufirst=A&rft.au=Flament-Durand,+J&rft.au=Karcher,+D&rft.au=Noppe,+M&rft.au=Brion,+JP&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Allard D, Gilbert S, Lamontagne A, Hamel D, Bélanger L (1995). "Identification of rat alpha-albumin and cDNA cloning of its human ortholog". Gene. 153 (2): 287–8\. doi:10.1016/0378-1119(94)00745-E. PMID 7875606.287-8&rft.date=1995&rft_id=info:doi/10.1016/0378-1119(94)00745-E&rft_id=info:pmid/7875606&rft.aulast=Allard&rft.aufirst=D&rft.au=Gilbert,+S&rft.au=Lamontagne,+A&rft.au=Hamel,+D&rft.au=Bélanger,+L&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Nishio H, Heiskanen M, Palotie A, Bélanger L, Dugaiczyk A (1996). "Tandem arrangement of the human serum albumin multigene family in the sub-centromeric region of 4q: evolution and chromosomal direction of transcription". J. Mol. Biol. 259 (1): 113–9\. doi:10.1006/jmbi.1996.0306. PMID 8648639.113-9&rft.date=1996&rft_id=info:doi/10.1006/jmbi.1996.0306&rft_id=info:pmid/8648639&rft.aulast=Nishio&rft.aufirst=H&rft.au=Heiskanen,+M&rft.au=Palotie,+A&rft.au=Bélanger,+L&rft.au=Dugaiczyk,+A&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Nishio H, Dugaiczyk A (1996). "Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7557–61\. Bibcode:1996PNAS...93.7557N. doi:10.1073/pnas.93.15.7557. PMC 38784. PMID 8755513.7557-61&rft.date=1996&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38784#id-name=PMC&rft_id=info:pmid/8755513&rft_id=info:doi/10.1073/pnas.93.15.7557&rft_id=info:bibcode/1996PNAS...93.7557N&rft.aulast=Nishio&rft.aufirst=H&rft.au=Dugaiczyk,+A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38784&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Song YH, Naumova AK, Liebhaber SA, Cooke NE (1999). "Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster". Genome Res. 9 (6): 581–7\. doi:10.1101/gr.9.6.581. PMC 310762. PMID 10400926.581-7&rft.date=1999&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310762#id-name=PMC&rft_id=info:pmid/10400926&rft_id=info:doi/10.1101/gr.9.6.581&rft.aulast=Song&rft.aufirst=YH&rft.au=Naumova,+AK&rft.au=Liebhaber,+SA&rft.au=Cooke,+NE&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310762&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Khan MA, Kumar Y, Tayyab S (2003). "Bilirubin binding properties of pigeon serum albumin and its comparison with human serum albumin". Int. J. Biol. Macromol. 30 (3–4): 171–8\. doi:10.1016/S0141-8130(02)00017-X. PMID 12063119.3–4&rft.pages=171-8&rft.date=2003&rft_id=info:doi/10.1016/S0141-8130(02)00017-X&rft_id=info:pmid/12063119&rft.aulast=Khan&rft.aufirst=MA&rft.au=Kumar,+Y&rft.au=Tayyab,+S&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Voegele AF, Jerković L, Wellenzohn B, Eller P, Kronenberg F, Liedl KR, Dieplinger H (2003). "Characterization of the vitamin E-binding properties of human plasma afamin". Biochemistry. 41 (49): 14532–8\. doi:10.1021/bi026513v. PMID 12463752.14532-8&rft.date=2003&rft_id=info:doi/10.1021/bi026513v&rft_id=info:pmid/12463752&rft.aulast=Voegele&rft.aufirst=AF&rft.au=Jerković,+L&rft.au=Wellenzohn,+B&rft.au=Eller,+P&rft.au=Kronenberg,+F&rft.au=Liedl,+KR&rft.au=Dieplinger,+H&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics. 4 (2): 454–65\. doi:10.1002/pmic.200300556. PMID 14760718. S2CID 29261009.454-65&rft.date=2004&rft_id=https://api.semanticscholar.org/CorpusID:29261009#id-name=S2CID&rft_id=info:pmid/14760718&rft_id=info:doi/10.1002/pmic.200300556&rft.aulast=Bunkenborg&rft.aufirst=J&rft.au=Pilch,+BJ&rft.au=Podtelejnikov,+AV&rft.au=Wiśniewski,+JR&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Jerkovic L, Voegele AF, Chwatal S, Kronenberg F, Radcliffe CM, Wormald MR, Lobentanz EM, Ezeh B, Eller P, Dejori N, Dieplinger B, Lottspeich F, Sattler W, Uhr M, Mechtler K, Dwek RA, Rudd PM, Baier G, Dieplinger H (2005). "Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression". J. Proteome Res. 4 (3): 889–99\. CiteSeerX 10.1.1.706.313. doi:10.1021/pr0500105. PMID 15952736.889-99&rft.date=2005&rft_id=https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.706.313#id-name=CiteSeerX&rft_id=info:pmid/15952736&rft_id=info:doi/10.1021/pr0500105&rft.aulast=Jerkovic&rft.aufirst=L&rft.au=Voegele,+AF&rft.au=Chwatal,+S&rft.au=Kronenberg,+F&rft.au=Radcliffe,+CM&rft.au=Wormald,+MR&rft.au=Lobentanz,+EM&rft.au=Ezeh,+B&rft.au=Eller,+P&rft.au=Dejori,+N&rft.au=Dieplinger,+B&rft.au=Lottspeich,+F&rft.au=Sattler,+W&rft.au=Uhr,+M&rft.au=Mechtler,+K&rft.au=Dwek,+RA&rft.au=Rudd,+PM&rft.au=Baier,+G&rft.au=Dieplinger,+H&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Hu Y, Malone JP, Fagan AM, Townsend RR, Holtzman DM (2006). "Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid". Mol. Cell. Proteomics. 4 (12): 2000–9\. doi:10.1074/mcp.M500207-MCP200. PMID 16199891.2000-9&rft.date=2006&rft_id=info:doi/10.1074/mcp.M500207-MCP200&rft_id=info:pmid/16199891&rft.aulast=Hu&rft.aufirst=Y&rft.au=Malone,+JP&rft.au=Fagan,+AM&rft.au=Townsend,+RR&rft.au=Holtzman,+DM&rft_id=https://doi.org/10.1074%2Fmcp.M500207-MCP200&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80\. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.2070-80&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850943#id-name=PMC&rft_id=info:pmid/16335952&rft_id=info:doi/10.1021/pr0502065&rft.aulast=Liu&rft.aufirst=T&rft.au=Qian,+WJ&rft.au=Gritsenko,+MA&rft.au=Camp,+DG&rft.au=Monroe,+ME&rft.au=Moore,+RJ&rft.au=Smith,+RD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850943&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">
* Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6): 1493–503\. doi:10.1021/pr050492k. PMID 16740002.1493-503&rft.date=2006&rft_id=info:doi/10.1021/pr050492k&rft_id=info:pmid/16740002&rft.aulast=Ramachandran&rft.aufirst=P&rft.au=Boontheung,+P&rft.au=Xie,+Y&rft.au=Sondej,+M&rft.au=Wong,+DT&rft.au=Loo,+JA&rfr_id=info:sid/en.wikipedia.org:Afamin" class="Z3988">

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