amino-acid racemase

Identifiers
EC no.| 5.1.1.10
CAS no.| 9068-61-5
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
| Search

PMC| articles
PubMed| articles
NCBI| proteins

In enzymology, an amino-acid racemase (EC 5.1.1.10) is an enzyme that catalyzes the chemical reaction

an L-amino acid  ⇌ {\displaystyle \rightleftharpoons } a D-amino acid

Hence, this enzyme has one substrate, L-amino acid, and one product, D-amino acid.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is amino-acid racemase. This enzyme is also called L-amino acid racemase. This enzyme participates in 4 metabolic pathways: glycine, serine and threonine metabolism, cysteine metabolism, D-glutamine and D-glutamate metabolism, and D-arginine and D-ornithine metabolism. It employs one cofactor, pyridoxal phosphate.

## Structural studies

[edit]

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2FKP, 2GGG, 2GGH, 2GGI, and 2GGJ.

## References

[edit]

* Soda K, Osumi T (1969). "Crystalline amino acid racemase with low substrate specificity". Biochem. Biophys. Res. Commun. 35 (3): 363–8\. Bibcode:1969BBRC...35..363S. doi:10.1016/0006-291X(69)90507-5. PMID 5788493.

* v
* t
* e

Isomerases: Epimerase and racemases (EC 5.1)

5.1.1: Amino acids|

* Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing)
* Serine racemase

5.1.2: Hydroxy acids|

* Mandelate racemase
* Isocitrate epimerase

5.1.3: Carbohydrates|

* UDP-glucose 4-epimerase
* N-acetylneuraminate epimerase
* Phosphopentose epimerase

5.1.99: Other|

* Methylmalonyl CoA epimerase

* v
* t
* e

Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

Portal:

* Biology

This isomerase article is a stub. You can help Wikipedia by expanding it.

* v
* t
* e

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template