Amit Singh (scientist)

Indian microbiologist

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Amit Singh

Born|  (1976-03-18) March 18, 1976 (age 49)

India

Alma mater|

* Indian Institute of Technology Roorkee
* University of Delhi South Campus
* University of Alabama at Birmingham

Known for| Mycobacterium tuberculosis pathogenesis
Awards|

* 2021 Shanti Swarup Bhatnagar Prize for Science and Technology
* 2017/18 N-BIOS Prize

Scientific career
Fields|

* Microbiology

Institutions|

* International Centre for Genetic Engineering and Biotechnology
* Indian Institute of Science

Doctoral advisor|

* Anil Kumar Tyagi
* Adrie JC Steyn

Amit Singh (born 18 March 1976) is an Indian microbiologist who is a professor in the Department of Microbiology & Cell Biology at the Indian Institute of Science. His research focuses on pathogenesis, including drug resistance mechanisms in both mycobacterium tuberculosis (TB) and human immunodeficiency viruses (HIV).

## Biography

[edit]

Amit Singh was born on 18 March 1976.[1] He earned a bachelor's degree in Science from the University of Delhi and a master's degree in Biotechnology from Indian Institute of Technology Roorkee in 1998.[2] In 2004, he completed a PhD under the supervision of Professor Anil Kumar Tyagi at the University of Delhi South Campus. Subsequently, he conducted postdoctoral research in the lab of Dr. Adrie JC Steyn at the University of Alabama in Birmingham(UAB) in the US.[3]

Upon returning to India in 2010, Singh held a Wellcome Trust-DBT Intermediate Fellowship at the International Centre for Genetic Engineering and Biotechnology. In January 2014, he joined the Indian Institute of Science (IISc) in the department of microbiology and cell biology as a professor.[4] He leads a research group at the Centre for Infectious Disease Research,[5] investigating the mechanisms of chronic human infections with a focus on Mycobacterium tuberculosis and human immunodeficiency virus (HIV).[6][7][8]

## Awards

[edit]

Singh has held a Welcome Trust-DBT Senior Fellowship since 2016.[9][10] He received the 2017/18 National Bioscience Award for Career Development from the Department of Biotechnology of the Government of India.[11]

Singh is a co-inventor on a patent titled "Shortening Tuberculosis Therapy and Reducing Relapse by Co-administering Chloroquine in TB and HIV-TB Co-infected Conditions," filed in 2020 and published in 2021.

In 2021, Singh was awarded the Shanti Swarup Bhatnagar Prize for Science and Technology for his contributions to understanding host-pathogen interactions in Mycobacterium tuberculosis and HIV.[12] In 2022, Singh was included in the Asian Scientist 100 list.

## Publications

[edit]

### Most cited articles at University of Alabama

[edit]

* Singh, A; Crossman, DK; Mai, D; Guidry, L; Voskuil, MI; Renfrow, MB; Steyn, AJ (2009). "Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response". PLOS Pathog. 5 (8): e1000545. doi:10.1371/journal.ppat.1000545. PMC 2718811. PMID 19680450. (Cited by 204 articles according to Google Scholar.)
* Singh, A; Guidry, L; Narasimhulu, KV; Mai, D; Trombley, J; Redding, KE; Giles, GI; Lancaster, JR Jr; Steyn, AJ (2007). "Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival". Proc Natl Acad Sci U S A. 104 (28): 11562–7\. Bibcode:2007PNAS..10411562S. doi:10.1073/pnas.0700490104. PMC 1906726. PMID 17609386. (Cited by 154 articles according to Google Scholar.)

### Most cited articles at IISc

[edit]

* Ashima Bhaskar, Manbeena Chawla, Mansi Mehta, Pankti Parikh, Pallavi Chandra, Devayani Bhave, Dhiraj Kumar, Kate S Carroll, Amit Singh. Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection. 2014. PLOS Pathogens. 10:1 e1003902. (Cited by 88 articles according to Google Scholar.)
* Rufai SB, Kumar P, Singh A, Prajapati S, Balooni V, Singh S. Comparison of Xpert MTB/RIF with line probe assay for detection of rifampin-monoresistant Mycobacterium tuberculosis. Journal of clinical microbiology. 2014 June; 52 (6): 1846–52. (Cited by 76 articles according to Google Scholar.)
* Chawla M, Parikh P, Saxena A, Munshi M, Mehta M, Mai D, Srivastava AK, Narasimhulu KV, Redding KE, Vashi N, Kumar D. Adrie JC Steyn and Amit Singh. Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo. Molecular microbiology. 2012 September; 85 (6): 1148–65. (Cited by 56 articles according to Google Scholar.)

## References

[edit]

1. ^ "Scientist Amit Singh". Hindi Info World. 26 November 2021. Archived from the original on 8 January 2022.
2. ^ "Centre for Infectious Disease Research (CIDR)". cidr.iisc.ernet.in. 11 January 2019. Archived from the original on 12 January 2019. Retrieved 11 January 2019.
3. ^ "India Alliance - Advancing Discovery & Innovation to Improve Health". www.indiaalliance.org. Retrieved 13 March 2025.
4. ^ "MCB". mcbl.iisc.ac.in. 11 January 2019. Archived from the original on 13 January 2019. Retrieved 11 January 2019.
5. ^ "Centre for Infectious Disease Research (CIDR) Group Leader". cidr.iisc.ernet.in. 11 January 2019. Archived from the original on 12 January 2019. Retrieved 11 January 2019.
6. ^ "Centre for Infectious Disease Research (CIDR) fellows". cidr.iisc.ac.in. 11 January 2019. Archived from the original on 3 July 2018. Retrieved 11 January 2019.
7. ^ "Welcome to lab web page of Dr. Amit Singh". cidr.iisc.ac.in. 11 January 2019. Archived from the original on 4 October 2018. Retrieved 11 January 2019.
8. ^ Bhaskar, Ashima; Chawla, Manbeena; Mehta, Mansi; Parikh, Pankti; Chandra, Pallavi; Bhave, Devayani; Kumar, Dhiraj; Carroll, Kate; Singh, Amit (2014). "Reengineering Redox Sensitive GFP to Measure Mycothiol Redox Potential of Mycobacterium tuberculosis during Infection". PLOS Pathogens. 10 (1): e1003902. doi:10.1371/journal.ppat.1003902. PMC 3907381. PMID 24497832.
9. ^ "India Alliance - About Fellow". www.indiaalliance.org. 11 January 2019. Retrieved 11 January 2019.
10. ^ "Amit Singh Group, Indian Institute of Science, Bangalore -- Publication". Retrieved 8 May 2019.
11. ^ "Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2016. Archived from the original (PDF) on 4 March 2018. Retrieved 20 November 2017.
12. ^ "Shanti Swarup Bhatnagar Prize (SSB) for Science and Technology 2021" (PDF). sbprize.gov.in. Council of Scientific and Industrial Research. Retrieved 26 September 2021.

## Further reading

[edit]

* Prasad, R. (29 September 2018). "IISc team finds new approaches to kill TB bacteria". The Hindu. Retrieved 11 January 2019.
* "How do TB bacteria develop resistance to common antibiotics? A new study at IISc attempts to answer this". Research Matters. 6 July 2017. Retrieved 11 January 2019.

## External links

[edit]

* Official home page at IISc

* v
* t
* e

N-BIOS Laureates 2010–2019

2010|

* Shantanu Chowdhury
* Balasubramanian Gopal
* R. Ashalatha
* Vinay K. Nandicoori
* Suman Kumar Dhar
* Ravishankar Ramachandran
* P. Karthe
* Dipshikha Chakravortty
* Debasis Chattopadhyay
* Anirban Basu

2011|

* Sagar Sengupta
* Niyaz Ahmed
* Santasabuj Das
* Ashish Arora
* Maneesha S. Inamdar
* Asif Mohmmed
* Shantanu Sengupta
* Sujata Sharma
* Dibyendu Sarkar
* M. M. Parida

2012|

* Vidita Vaidya
* Sathees Chukkurumbal Raghavan
* Asad Ullah Khan
* Munia Ganguli
* S. Venkata Mohan
* Durai Sundar
* Subrata Adak
* Aditya Bhushan Pant
* Naval Kishore Vikram
* Kaustuv Sanyal

2013|

* Govindan Rajamohan
* A. K. Mukherjee
* Alok Krishna Sinha

2014|

* Manoj Prasad
* Bikramjit Basu
* Debasis Dash
* Ashish Suri
* Deepak Thankappan Nair
* Ramandeep Singh
* Fayaz A. Malik
* Patrick D'Silva
* Deepak Gaur
* Kausik Chattopadhyay

2015|

* Sanjeev Das
* Ganesh Nagaraju
* Suvendra Nath Bhattacharyya
* H. V. Thulasiram
* Pawan Gupta
* Souvik Maiti
* Pravindra Kumar
* Anurag Agrawal
* Girdhar Kumar Pandey
* Sanjib Senapati

2017/18|

* Manas Kumar Santra
* Dipyaman Ganguly
* Subhadeep Chatterjee
* Soumen Basak
* Manoj Majee
* Arun Kumar Shukla
* Amit Singh
* Maddika Subba Reddy
* Beena Ramakrishnan Pillai
* Ashwani Kumar
* Mohammad Zahid Ashraf
* Ranjith Padinhateeri
* Suresh Kumar Rayala
* Prabhu B. Patil
* Pritam Deb

* v
* t
* e

Recipients of Shanti Swarup Bhatnagar Prize for Science and Technology in Biological Science

1960s|

* Toppur Seethapathy Sadasivan (1960)
* M. S. Swaminathan (1961)
* Bimal Kumar Bachhawat (1962)
* Jagannath Ganguly (1963}
* Dilbagh Singh Athwal (1964)
* Chirayathumadom Venkatachalier Subramanian (1965)
* Hari Krishan Jain (1966)
* Neelamraju Ganga Prasada Rao (1966)
* Arun Kumar Sharma (1967)
* Tathamangalam Ananthanarayanan Venkitasubramanian (1968)

1970s|

* Madhu Sudan Kanungo (1971)
* Narayana Balakrishnan Nair (1971)
* Birendra Bijoy Biswas (1972)
* Satish Chandra Maheshwari (1972)
* Bhyravabhotla Radhakrishna Murty (1973)
* Sardul Singh Guraya (1973)
* John Barnabas (1974)
* Obaid Siddiqi (1975)
* Archana Sharma (1975)
* Guru Prakash Dutta (1976)
* Kishan Singh (1976)
* Trichnopoly Chelvaraj Anand Kumar (1977)
* V. Sasisekharan (1978)
* Amar Nath Bhaduri (1979)
* M. K. Chandrashekaran (1979)

1980s|

* Asis Datta (1980)
* Jamuna Sharan Singh (1980)
* Prafullachandra Vishnu Sane (1981)
* Sushil Kumar (1981)
* Sunil Kumar Podder (1982)
* Ramamirtha Jayaraman (1982)
* Govindarajan Padmanabhan (1983)
* Thavamani Jegajothivel Pandian (1984)
* K. R. K. Easwaran (1984)
* Chhitar Mal Gupta (1985)
* M. Vijayan (1985)
* Madhav Gadgil (1986)
* Avadhesha Surolia
* Sudhir Kumar Sopory
* Bhabatarak Bhattacharyya (1988)
* M. R. S. Rao (1988)
* Subhash Chandra Lakhotia (1989)
* Manju Ray (1989)

1990s|

* Samir K. Brahmachari (1990)
* Virendra Nath Pandey (1991)
* Srinivas Kishanrao (1991)
* Kuppamuthu Dharmalingam (1992)
* Dipankar Chatterji (1992)
* Raghavendra Gadagkar (1993)
* M. R. N. Murthy (1993)
* Ramakrishnan Nagaraj (1994)
* Alok Bhattacharya (1994)
* Seyed E. Hasnain (1995)
* Kalappa Muniyappa (1995)
* Ghanshyam Swarup (1996)
* Vishweshwaraiah Prakash (1996)
* Jayaraman Gowrishankar (1997)
* Kanury Venkata Subba Rao (1997)
* K. VijayRaghavan (1998)
* Debi Prasad Sarkar (1998)
* Siddhartha Roy (1999)
* Valakunja Nagaraja (1999)

2000s|

* Dinakar Mashnu Salunke (2000)
* Jayant B. Udgaonkar (2000)
* Umesh Varshney (2001)
* Raghavan Varadarajan (2002)
* Amitabha Mukhopadhyay (2002)
* Satyajit Mayor (2003)
* Gopal Chandra Kundu (2004)
* Ramesh Venkata Sonti (2004)
* Tapas Kumar Kundu (2005)
* Shekhar C. Mande (2005)
* Vinod Bhakuni (2006)
* Rajesh Sudhir Gokhale (2006)
* Upinder Singh Bhalla (2007)
* Narayanaswamy Srinivasan (2007)
* Gajendra Pal Singh Raghava (2008)
* L. S. Shashidhara (2008)
* Amitabh Joshi (2009)
* Bhaskar Saha (2009)

2010s|

* Sanjeev Galande (2010)
* Shubha Tole (2010)
* Amit Prakash Sharma (2011)
* Rajan Sankaranarayanan (2011)
* Shantanu Chowdhury (2012)
* Suman Kumar Dhar (2012)
* Sathees Chukkurumbal Raghavan (2013)
* Roop Mallik (2014)
* Balasubramanian Gopal (2015)
* Rajeev Kumar Varshney (2015)
* Suvendra Nath Bhattacharyya (2016)
* Rishikesh Narayanan (2016)
* Deepak T. Nair (2017)
* Sanjeev Das (2017)
* Ganesh Nagaraju (2018)
* Thomas J. Pucadyil (2018)
* Kayarat Saikrishnan (2019)

2020s|

* Subhadeep Chatterjee (2020)
* Vatsala Thirumalai (2020)
* Amit Singh (2021)
* Arun Kumar Shukla (2021)
* Ashwani Kumar (2022)
* Maddika Subba Reddy (2022)

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