Anti-p62 antibodies

Autoantibody

Anti-p62
Autoantigen
Isoform | Nucleoporin 62kDA
Autoantigen gene | NUP62
Affected organ(s) | Bile duct
Associated
Disease(s) | Primary biliary cirrhosis
HLA associations | DR2 (weak)

Anti-p62 antibodies (AP62A) are found in a primary biliary cirrhosis.[1] The p62 protein is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease.[2][3] The autoantigen is the nucleoporin 62kDA protein.

## References

[edit]

1. ^ Wesierska-Gadek J, Hohenuer H, Hitchman E, Penner E (1996). "Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis". Gastroenterology. 110 (3): 840–7\. doi:10.1053/gast.1996.v110.pm8608894. PMID 8608894.
2. ^ Miyachi K, Hankins RW, Matsushima H, et al. (2003). "Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study". J. Autoimmun. 20 (3): 247–54\. doi:10.1016/S0896-8411(03)00033-7. PMID 12753810.
3. ^ Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J (2005). "Antinuclear antibodies in primary biliary cirrhosis". Semin. Liver Dis. 25 (3): 298–310\. doi:10.1055/s-2005-916321. PMID 16143945.

* v
* t
* e

Autoantibodies

Anti-nuclear antibody|

* PBC:
* Anti-gp210
* Anti-p62
* Anti-sp100

* ENA:
* Anti-topoisomerase/Scl-70
* Anti-Jo1
* ENA4
* Anti-Sm
* Anti-nRNP
* Anti-Ro
* Anti-La

* Anti-centromere

* Anti-dsDNA

* Anti-histone

Anti-mitochondrial antibody|

* Anti-cardiolipin

Anti-cytoplasm antibody|

* Anti-neutrophil cytoplasmic
* C-ANCA
* P-ANCA
* Anti-smooth muscle
* Anti-actin
* Anti-TPO/Antimicrosomal

Cell membrane|

* Anti-ganglioside
* Anti-GBM
* Anti-glutamate

Extracellular|

* Anti-thrombin
* Lupus anticoagulant

* Coeliac disease:
* Anti-transglutaminase
* Anti-gliadin not autoantibody

* RA
* Rheumatoid factor
* Anti-citrullinated peptide

Multiple locations|

* Anti-phospholipid
* Anti-apolipoprotein

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template