Apocrine nevus

Medical condition

Apocrine nevus

Other names| Apocrine gland hamartoma
Specialty| Medical genetics

An Apocrine nevus is an extremely rare cutaneous condition that is composed of hyperplastic mature apocrine glands.[1]: 775 Apocrine nevi present as a nodular skin-coloured lump. They are typically asymptomatic. Apocrine nevi can be congenital and they have been associated with other disorders.

## Signs and symptoms[edit]

Apocrine nevi manifests as a persistent pedunculated or nodular skin-coloured axillary lump.[2] Additionally, reports of them occurring on the face,[3][4] scalp,[5] chest,[6] and inguinal area have been made.[7] The majority of the time, apocrine nevi are asymptomatic, although some individuals describe minor pain, baldness, or in rare cases, leakage.[8][9]

## Causes[edit]

Apocrine nevi may be congenital.[9] There have been reported associations with neurofibromatosis,[6] epilepsy,[8] and localized dermal hypoplasia, but these may be coincidental.[10]

## Diagnosis[edit]

According to histopathology, apocrine nevi are made up of several mature apocrine sweat glands grouped in lobules that invade the dermis and/or hypodermis and cause normal skin structures to be displaced. There may be some cystic dilatation of the lumina in these glands.[11]

## See also[edit]

* Eccrine nevus
* Seborrheic keratosis
* List of cutaneous conditions

## References[edit]

1. ^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
2. ^ Cordero, Steven C; Royer, Michael C; Rush, Walter L; Hallman, James R; Lupton, George P (2012). "Pure Apocrine Nevus". The American Journal of Dermatopathology. 34 (3). Ovid Technologies (Wolters Kluwer Health): 305–309. doi:10.1097/dad.0b013e31823adf0e. ISSN 0193-1091. PMID 22317889.
3. ^ MISAGO, Noriyuki; NARISAWA, Yutaka (2006). "Syringocystadenoma papilliferum with extensive apocrine nevus". The Journal of Dermatology. 33 (4). Wiley: 303–305. doi:10.1111/j.1346-8138.2006.00073.x. ISSN 0385-2407. PMID 16674800.
4. ^ Schwartz, Robert A.; Rojas-Corona, Rogelio; Lambert, W. Clark (1984). "The polymorphic apocrine nevus: A study of a unique tumor including carcinoembryonic antigen staining". Journal of Surgical Oncology. 26 (3). Wiley: 183–186. doi:10.1002/jso.2930260309. ISSN 0022-4790. PMID 6738068.
5. ^ BURDEN, PATRICIA A.; GENTRY, RICHARD H.; FITZPATRICK, JAMES E. (1987). "Piloleiomyoma Arising in an Organoid Nevus: A Case Report and Review of the Literature". The Journal of Dermatologic Surgery and Oncology. 13 (11). Wiley: 1213–1222. doi:10.1111/j.1524-4725.1987.tb02433.x. ISSN 0148-0812. PMID 3312332.
6. ^ a b Kim, Joong Hwan; Hur, Hoon; Lee, Chang Woo; Kim, Young Tae (1988). "Apocrine nevus". Journal of the American Academy of Dermatology. 18 (3). Elsevier BV: 579–581. doi:10.1016/s0190-9622(88)80291-3. ISSN 0190-9622. PMID 3127435.
7. ^ Mori, Osamu; Hachisuka, Hiroshi; Sasai, Yoichiro (1993). "APOCRINE NEVUS". International Journal of Dermatology. 32 (6): 448–449. doi:10.1111/j.1365-4362.1993.tb02821.x. ISSN 0011-9059. PMID 8320030.
8. ^ a b Neill, J. S. A.; Park, H. Kim (1993). "Apocrine nevus: light microscopic, immunohistochemical and ultrastructural studies of a case". Journal of Cutaneous Pathology. 20 (1). Wiley: 79–83. doi:10.1111/j.1600-0560.1993.tb01255.x. ISSN 0303-6987. PMID 8468422.
9. ^ a b Herrmann, James J.; Eramo, Lynne R. (1995). "Congenital Apocrine Hamartoma: An Unusual Clinical Variant of Organoid Nevus with Apocrine Differentiation". Pediatric Dermatology. 12 (3). Wiley: 248–251. doi:10.1111/j.1525-1470.1995.tb00170.x. ISSN 0736-8046. PMID 7501558.
10. ^ Vakilzadeh, Fereydoun; Happle, Rudolf; Peters, Peter; Macher, Egon (1976). "Fokale dermale hypoplasie mit apokrinen naevi und streifenförmiger anomalie der knochen". Archives of Dermatological Research (in German). 256 (2): 189–195. doi:10.1007/BF00567364. ISSN 0340-3696. PMID 822789.
11. ^ Kanitakis, J.; Kyamidis, K.; Toussinas, A.; Tsoïtis, G. (2011). "Pure Apocrine Nevus: Immunohistochemical Study of a New Case and Literature Review". Dermatology. 222 (2): 97–101. doi:10.1159/000323000. ISSN 1018-8665. PMID 21212656.

## Further reading[edit]

* Ando, Ko-ichi; Hashikawa, Yuko; Nakashima, Mikio; Nakayama, Atsuo; Ohashi, Masaru (1991). "Pure Apocrine Nevus A Study of Light-Microscopic and Immunohistochemical Features of a Rare Tumor". The American Journal of Dermatopathology. 13 (1). Ovid Technologies (Wolters Kluwer Health): 71–76. doi:10.1097/00000372-199102000-00012. ISSN 0193-1091. PMID 2003651.
* Numata, Yukikazu; Okuyama, Ryuhei; Terui, Tadashi; Sasai, Shu; Tagami, Hachiro; Aiba, Setsuya (2006). "Apocrine Nevus in Abdominal Skin". Dermatology. 213 (1). S. Karger AG: 46–47. doi:10.1159/000092839. ISSN 1018-8665. PMID 16778428.

## External links[edit]

Classification|

* ICD-11: LC0Y
* ICD-10: Q82.5
* SNOMED CT: 239120005

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External resources|

* Scholia: Q4780134