BET1L

Protein-coding gene in the species Homo sapiens

BET1L

Identifiers
Aliases| BET1L, BET1L1, GOLIM3, GS15, HSPC197, Bet1 golgi vesicular membrane trafficking protein like
External IDs| OMIM: 615417; MGI: 1913128; HomoloGene: 10293; GeneCards: BET1L; OMA:BET1L - orthologs
| Gene location (Human)

Chr.| Chromosome 11 (human)[1]

Band| 11p15.5| Start| 167,784 bp[1]
End| 207,399 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 7 (mouse)[2]

Band| 7|7 F4| Start| 140,433,307 bp[2]
End| 140,437,490 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* body of pancreas

* anterior pituitary

* left ovary

* right coronary artery

* Descending thoracic aorta

* body of stomach

* gastric mucosa

* canal of the cervix

* ascending aorta

* stromal cell of endometrium

| Top expressed in

* dentate gyrus of hippocampal formation granule cell

* molar

* parotid gland

* granulocyte

* seminal vesicula

* calvaria

* spermatocyte

* motor neuron

* crypt of lieberkuhn of small intestine

* decidua

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* SNAP receptor activity

Cellular component|

* integral component of membrane
* Golgi membrane
* endosome
* Golgi apparatus
* SNARE complex
* membrane
* cytosol
* Golgi trans cisterna
* Golgi stack
* integral component of Golgi membrane

Biological process|

* protein transport
* endoplasmic reticulum to Golgi vesicle-mediated transport
* retrograde transport, endosome to Golgi
* regulation of retrograde vesicle-mediated transport, Golgi to ER
* membrane fusion
* transport

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

51272

54399

Ensembl| |

ENSG00000177951

ENSMUSG00000025484

UniProt| |

Q9NYM9

O35153

RefSeq (mRNA)| |

NM_016526
NM_001098787
NM_016465

NM_018742

RefSeq (protein)| |

NP_001092257
NP_057610

NP_061212

Location (UCSC)| Chr 11: 0.17 – 0.21 Mb| Chr 7: 140.43 – 140.44 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

BET1-like protein is a protein that in humans is encoded by the BET1L gene.[5][6][7]

## Interactions

[edit]

BET1L has been shown to interact with:

* GOSR1,[8][9]
* STX5,[8][9] and
* YKT6.[8][9]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177951 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025484 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Xu Y, Wong SH, Zhang T, Subramaniam VN, Hong W (Sep 1997). "GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1". J Biol Chem. 272 (32): 20162–6\. doi:10.1074/jbc.272.32.20162. PMID 9242691.
6. ^ Oka T, Ungar D, Hughson FM, Krieger M (Apr 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Mol Biol Cell. 15 (5): 2423–35\. doi:10.1091/mbc.E03-09-0699. PMC 404034. PMID 15004235.
7. ^ "Entrez Gene: BET1L blocked early in transport 1 homolog (S. cerevisiae)-like".
8. ^ a b c Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62\. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
9. ^ a b c Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell. 13 (10): 3493–507\. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.

## External links

[edit]

* Human BET1L genome location and BET1L gene details page in the UCSC Genome Browser.

## Further reading

[edit]

* Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13\. doi:10.1006/abio.1996.0138. PMID 8619474.
* Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8\. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
* Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60\. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
* Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51\. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
* Zhang T, Hong W (2001). "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport". J. Biol. Chem. 276 (29): 27480–7\. doi:10.1074/jbc.M102786200. PMID 11323436.
* Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62\. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
* Xu Y, Martin S, James DE, Hong W (2003). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell. 13 (10): 3493–507\. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903\. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5\. doi:10.1038/ng1285. PMID 14702039.
* Tai G, Lu L, Wang TL, et al. (2005). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Mol. Biol. Cell. 15 (9): 4011–22\. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7\. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65\. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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