Benzyl isothiocyanate

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Names
Preferred IUPAC name

(Isothiocyanatomethyl)benzene

Identifiers

CAS Number

* 622-78-6 Y

3D model (JSmol)

* Interactive image

ChemSpider |

* 2256

ECHA InfoCard | 100.009.777

PubChem CID

* 2346

UNII |

* 871J6YOR8Q Y

CompTox Dashboard (EPA)

* DTXSID0020155

InChI

* InChI=1S/C8H7NS/c10-7-9-6-8-4-2-1-3-5-8/h1-5H,6H2

Key: MDKCFLQDBWCQCV-UHFFFAOYSA-N

SMILES

* c1ccc(cc1)CN=C=S

Properties

Chemical formula

| C8H7NS
Molar mass | 149.21 g·mol−1
Density | 1.125 g/mL[1]
Boiling point | 242-243[1]

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

Chemical compound

Benzyl isothiocyanate (BITC) is an isothiocyanate found in plants of the mustard family.

## Occurrence

[edit]

It can be found in Alliaria petiolata, pilu oil, and papaya seeds[2] where it is the main product of the glucotropaeolin breakdown by the enzyme myrosinase.

## Activity

[edit]

Benzyl isothiocyanate, and other isothiocyanates in general, were found to be protective against pancreatic carcinogenesis in vitro[3] via expression of the p21/WAF1 gene.[4] A recent published study showed its restraining impact on obesity, fatty liver, and insulin resistance in diet-induced obesity mouse model.[5]

## References

[edit]

1. ^ a b "Benzyl isothiocyanate". Sigma-Aldrich.
2. ^ Nakamura, Yoshimasa; Yoshimoto, Motoko; Murata, Yoshiyuki; Shimoishi, Yasuaki; Asai, Yumi; Park, Eun Young; Sato, Kenji; Nakamura, Yasushi (2007). "Papaya Seed Represents a Rich Source of Biologically Active Isothiocyanate". Journal of Agricultural and Food Chemistry. 55 (11): 4407–13\. doi:10.1021/jf070159w. PMID 17469845.
3. ^ Kuroiwa, Yuichi; Nishikawa, Akiyoshi; Kitamura, Yasuki; Kanki, Keita; Ishii, Yuji; Umemura, Takashi; Hirose, Masao (2006). "Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters". Cancer Letters. 241 (2): 275–80\. doi:10.1016/j.canlet.2005.10.028. PMID 16386831.
4. ^ Moon, Sung-Kwon; Choi, Yung-Hyun; Kim, Cheorl-Ho; Choi, Won-Seok (2006). "P38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1". Biochemical and Biophysical Research Communications. 350 (3): 662–8\. doi:10.1016/j.bbrc.2006.09.092. PMID 17026958.
5. ^ Alsanea, Sary; Liu, Dexi (November 2017). "BITC and S-Carvone Restrain High-Fat Diet-Induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance". Pharmaceutical Research. 34 (11): 2241–2249\. doi:10.1007/s11095-017-2230-3. ISSN 1573-904X. PMC 5757875. PMID 28733781.

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Cruciferous biochemistry

Types of compounds|

* Phenylthiocarbamide (PTC/PTU)
* Thiocyanates
* Nitriles
* Indoles
* Gibberellin

Glucosinolates|

* Glucobrassicin
* Glucocapparin
* Glucoraphanin
* Gluconasturtiin
* Glucotropaeolin
* Progoitrin
* Sinigrin
* Sinalbin

Isothiocyanates (ITC, mustard oils)|

* Sulforaphane (SFN)
* Raphanin
* Allyl isothiocyanate (AITC)
* Methyl isothiocyanate (MITC)
* Benzyl isothiocyanate (BITC)
* Fluorescein isothiocyanate (FITC)
* Phenyl isothiocyanate (PITC)
* Phenethyl isothiocyanate (PEITC)
* 6-MITC
* Erucin

Bioactive metabolites|

* Goitrin
* Indole-3-carbinol

* Brassicaceae (Cruciferous vegetables): Brassica
* Cruciferous Biochemistry
* genera (list)

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