Brain-specific angiogenesis inhibitor 1

Protein-coding gene in the species Homo sapiens

ADGRB1

Identifiers
Aliases| ADGRB1, BAI1, GDAIF, adhesion G protein-coupled receptor B1
External IDs| OMIM: 602682 MGI: 1933736 HomoloGene: 1287 GeneCards: ADGRB1
| Gene location (Human)

Chr.| Chromosome 8 (human)[1]

Band| 8q24.3| Start| 142,449,430 bp[1]
End| 142,545,009 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 15 (mouse)[2]

Band| 15|15 D3| Start| 74,388,044 bp[2]
End| 74,461,314 bp[2]
| RNA expression pattern

Bgee| | Top expressed in

* nucleus accumbens

* cingulate gyrus

* amygdala

* Brodmann area 9

* caudate nucleus

* putamen

* prefrontal cortex

* hypothalamus

* anterior pituitary

* Ganglionic eminence

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* G protein-coupled receptor activity
* signal transducer activity
* transmembrane signaling receptor activity
* lipopolysaccharide binding
* phosphatidylserine binding
* PDZ domain binding
* GO:0001948 protein binding

Cellular component|

* integral component of membrane
* integral component of plasma membrane
* cell-cell junction
* membrane
* phagocytic cup
* extracellular space
* plasma membrane
* focal adhesion
* GO:0097483, GO:0097481 postsynaptic density
* dendrite
* perinuclear region of cytoplasm
* extracellular region
* cell junction
* cell projection
* dendritic spine
* synapse
* postsynaptic membrane

Biological process|

* G protein-coupled receptor signaling pathway
* cell surface receptor signaling pathway
* peripheral nervous system development
* axonogenesis
* signal transduction
* negative regulation of cell population proliferation
* positive regulation of synapse assembly
* phagocytosis, recognition
* phagocytosis, engulfment
* negative regulation of endothelial cell migration
* negative regulation of angiogenesis
* negative regulation of protein ubiquitination
* negative regulation of protein catabolic process
* apoptotic cell clearance
* engulfment of apoptotic cell
* regulation of synaptic plasticity
* GO:0051636 defense response to Gram-negative bacterium
* positive regulation of myoblast fusion
* positive regulation of reactive oxygen species biosynthetic process
* immune system process
* phagocytosis
* cell adhesion
* nervous system development
* muscle organ development
* innate immune response
* adenylate cyclase-activating G protein-coupled receptor signaling pathway

Sources:Amigo / QuickGO
Orthologs
Species| Human| Mouse
Entrez| |

575

107831

Ensembl| |

ENSG00000181790

ENSMUSG00000034730

UniProt| |

O14514

Q3UHD1

RefSeq (mRNA)| |

NM_001702
NM_001391985
NM_001391986
NM_001391987
NM_001391988

NM_174991
NM_001359759

RefSeq (protein)| |

NP_001693

NP_778156
NP_001346688

Location (UCSC)| Chr 8: 142.45 – 142.55 Mb| Chr 15: 74.39 – 74.46 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene.[5][6] It is a member of the adhesion-GPCR family of receptors.[7]

## Contents

* 1 Function
* 2 Interactions
* 3 Model organisms
* 4 References
* 5 External links
* 6 Further reading

## Function[edit]

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.[6]

## Interactions[edit]

Brain-specific angiogenesis inhibitor 1 has been shown to interact with BAIAP3[8] and MAGI1.[9]

## Model organisms[edit]

Model organisms have been used in the study of BAI1 function. A conditional knockout mouse line called Bai1tm2a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[10] Male and female animals underwent a standardized phenotypic screen[11] to determine the effects of deletion.[12][13][14][15] Additional screens performed: - In-depth immunological phenotyping[16] \- in-depth bone and cartilage phenotyping[17]

Bai1 knockout mouse phenotype  Characteristic | Phenotype

|

All data available at.[11][16][17]
Peripheral blood leukocytes 6 Weeks | Normal
Haematology 6 Weeks | Normal
Insulin | Normal
Homozygous viability at P14 | Normal
Homozygous Fertility | Normal
General Observations | Abnormal
Body weight | Normal
Neurological assessment | Normal
Grip strength | Normal
Dysmorphology | Normal
Indirect calorimetry | Normal
Glucose tolerance test | Normal
Auditory brainstem response | Abnormal
DEXA | Normal
Radiography | Normal
Eye morphology | Normal
Clinical chemistry | Normal
Haematology 16 Weeks | Abnormal
Peripheral blood leukocytes 16 Weeks | Abnormal
Heart weight | Normal
Salmonella infection | Normal
Spleen Immunophenotyping | Normal
Mesenteric Lymph Node Immunophenotyping | Normal
Epidermal Immune Composition | Normal

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181790 \- Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034730 \- Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenetics and Cell Genetics. 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023.
6. ^ a b "Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1".
7. ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
8. ^ Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y (Oct 1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications. 251 (1): 158–65. doi:10.1006/bbrc.1998.9408. PMID 9790924.
9. ^ Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (Jun 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739.
10. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
11. ^ a b "International Mouse Phenotyping Consortium".
12. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
13. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
14. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
15. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
16. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium".
17. ^ a b "OBCD Consortium".

## External links[edit]

* Human ADGRB1 genome location and ADGRB1 gene details page in the UCSC Genome Browser.

## Further reading[edit]

* Van Meir EG, Polverini PJ, Chazin VR, Su Huang HJ, de Tribolet N, Cavenee WK (Oct 1994). "Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells". Nature Genetics. 8 (2): 171–6. doi:10.1038/ng1094-171. PMID 7531056. S2CID 38703307.
* Nishimori H, Shiratsuchi T, Urano T, Kimura Y, Kiyono K, Tatsumi K, Yoshida S, Ono M, Kuwano M, Nakamura Y, Tokino T (Oct 1997). "A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis". Oncogene. 15 (18): 2145–50. doi:10.1038/sj.onc.1201542. PMID 9393972.
* Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (Jun 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739.
* Fukushima Y, Oshika Y, Tsuchida T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Ueyama Y, Tamaoki N, Nakamura M (Nov 1998). "Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer". International Journal of Oncology. 13 (5): 967–70. doi:10.3892/ijo.13.5.967. PMID 9772287.
* Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y (Oct 1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications. 251 (1): 158–65. doi:10.1006/bbrc.1998.9408. PMID 9790924.
* Oda K, Shiratsuchi T, Nishimori H, Inazawa J, Yoshikawa H, Taketani Y, Nakamura Y, Tokino T (1999). "Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1". Cytogenetics and Cell Genetics. 84 (1–2): 75–82. doi:10.1159/000015219. PMID 10343108. S2CID 27688560.
* Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA (Jul 2000). "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase". The Journal of Biological Chemistry. 275 (28): 21477–85. doi:10.1074/jbc.M909741199. PMID 10748157.
* Koh JT, Lee ZH, Ahn KY, Kim JK, Bae CS, Kim HH, Kee HJ, Kim KK (Mar 2001). "Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein". Brain Research. Molecular Brain Research. 87 (2): 223–37. doi:10.1016/S0169-328X(01)00004-3. PMID 11245925.
* Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, Horii A, Tani K, Asano S, Nakamura Y, Matsuno S (Feb 2002). "Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis". British Journal of Cancer. 86 (3): 490–6. doi:10.1038/sj.bjc.6600067. PMC 2375213. PMID 11875720.
* Lim IA, Hall DD, Hell JW (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". The Journal of Biological Chemistry. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501.
* Mori K, Kanemura Y, Fujikawa H, Nakano A, Ikemoto H, Ozaki I, Matsumoto T, Tamura K, Yokota M, Arita N (May 2002). "Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells". Neuroscience Research. 43 (1): 69–74. doi:10.1016/S0168-0102(02)00018-4. PMID 12074842. S2CID 25538704.
* Kaur B, Brat DJ, Calkins CC, Van Meir EG (Jan 2003). "Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression". The American Journal of Pathology. 162 (1): 19–27. doi:10.1016/S0002-9440(10)63794-7. PMC 1851137. PMID 12507886.
* Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG (Dec 2002). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Molecular & Cellular Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
* Koh JT, Kook H, Kee HJ, Seo YW, Jeong BC, Lee JH, Kim MY, Yoon KC, Jung S, Kim KK (Mar 2004). "Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin". Experimental Cell Research. 294 (1): 172–84. doi:10.1016/j.yexcr.2003.11.008. PMID 14980512.
* Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

* v
* t
* e

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

| Neurotransmitter|

| Adrenergic|

* α1 (A
* B
* D)
* α2 (A
* B
* C)
* β1
* β2
* β3

|

Purinergic|

* Adenosine (A1
* A2A
* A2B
* A3)
* P2Y (1
* 2
* 4
* 5
* 6
* 8
* 9
* 10
* 11
* 12
* 13
* 14)

Serotonin|

* (all but 5-HT3) 5-HT1 (A
* B
* D
* E
* F)
* 5-HT2 (A
* B
* C)
* 5-HT (4
* 5A
* 6
* 7)

Other|

* Acetylcholine (M1
* M2
* M3
* M4
* M5)
* Dopamine
* D1
* D2
* D3
* D4
* D5
* GHB receptor
* Histamine
* H1
* H2
* H3
* H4
* Melatonin (1A
* 1B
* 1C)
* TAAR (1
* 2
* 5
* 6
* 8
* 9)

Metabolites and
signaling molecules|

| Eicosanoid|

* CysLT (1
* 2)
* LTB4
* 1
* 2
* FPRL1
* OXE
* Prostaglandin
* DP (1
* 2), EP (1
* 2
* 3
* 4), FP
* Prostacyclin
* Thromboxane

|

Other|

* Bile acid
* Cannabinoid (CB1
* CB2, GPR (18
* 55
* 119))
* EBI2
* Estrogen
* Free fatty acid (1
* 2
* 3
* 4)
* Hydroxycarboxylic acids
* 1
* 2
* 3
* Lysophosphatidic acid (1
* 2
* 3
* 4
* 5
* 6)
* Lysophospholipid (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8)
* Oxoglutarate
* PAF
* Sphingosine-1-phosphate (1
* 2
* 3
* 4
* 5)
* Succinate

Peptide|

| Neuropeptide|

* B/W (1
* 2)
* FF (1
* 2)
* S
* Y (1
* 2
* 4
* 5)
* Neuromedin (B
* U (1
* 2))
* Neurotensin (1
* 2)

|

Other|

* Anaphylatoxin (C3a
* C5a)
* Angiotensin (1
* 2)
* Apelin
* Bombesin
* BRS3
* GRPR
* NMBR)
* Bradykinin (B1
* B2)
* Chemokine
* Cholecystokinin (A
* B)
* Endothelin
* A
* B
* Formyl peptide (1
* 2
* 3)
* FSH
* Galanin (1
* 2
* 3)
* Gonadotropin-releasing hormone (1
* 2)
* Ghrelin
* Kisspeptin
* Luteinizing hormone/choriogonadotropin
* MAS (1
* 1L
* D
* E
* F
* G
* X1
* X2
* X3
* X4)
* Melanocortin (1
* 2
* 3
* 4
* 5)
* MCHR (1
* 2)
* Motilin
* Opioid (Delta
* Kappa
* Mu
* Nociceptin & Zeta, but not Sigma)
* Orexin (1
* 2)
* Oxytocin
* Prokineticin (1
* 2)
* Prolactin-releasing peptide
* Relaxin (1
* 2
* 3
* 4)
* Somatostatin (1
* 2
* 3
* 4
* 5)
* Tachykinin (1
* 2
* 3)
* Thyrotropin
* Thyrotropin-releasing hormone
* Urotensin-II
* Vasopressin (1A
* 1B
* 2)

Miscellaneous|

| Taste, bitter|

* TAS2R
* 1
* 3
* 4
* 5
* 7
* 8
* 9
* 10
* 13
* 14
* 16
* 19
* 20
* 30
* 31
* 38
* 39
* 40
* 41
* 42
* 43
* 45
* 46
* 50
* 60
* Vomeronasal receptor type 1

|

Orphan|

* GPR (1
* 3
* 4
* 6
* 12
* 15
* 17
* 18
* 19
* 20
* 21
* 22
* 23
* 25
* 26
* 27
* 31
* 32
* 33
* 34
* 35
* 37
* 39
* 42
* 44
* 45
* 50
* 52
* 55
* 61
* 62
* 63
* 65
* 68
* 75
* 77
* 78
* 81
* 82
* 83
* 84
* 85
* 87
* 88
* 92
* 101
* 103
* 109A
* 109B
* 119
* 120
* 132
* 135
* 137B
* 139
* 141
* 142
* 146
* 148
* 149
* 150
* 151
* 152
* 153
* 160
* 161
* 162
* 171
* 173
* 174
* 176
* 177
* 182
* 183)

Other|

* Adrenomedullin
* Olfactory
* Opsin (3
* 4
* 5
* 1LW
* 1MW
* 1SW
* RGR
* RRH)
* Protease-activated (1
* 2
* 3
* 4)
* SREB (1
* 2
* 3)

Class B: Secretin-like

| Adhesion|

* ADGRG (1
* 2
* 3
* 4
* 5
* 6
* 7)

|

Orphan|

* GPR (56
* 64
* 97
* 98
* 110
* 111
* 112
* 113
* 114
* 115
* 116
* 123
* 124
* 125
* 126
* 128
* 133
* 143
* 144
* 155
* 157)

Other|

* Brain-specific angiogenesis inhibitor (1
* 2
* 3)
* Cadherin (1
* 2
* 3)
* Calcitonin
* CALCRL
* CD97
* Corticotropin-releasing hormone (1
* 2)
* EMR (1
* 2
* 3)
* Glucagon (GR
* GIPR
* GLP1R
* GLP2R)
* Growth-hormone-releasing hormone
* PACAPR1
* GPR
* Latrophilin (1
* 2
* 3
* ELTD1)
* Methuselah-like proteins
* Parathyroid hormone (1
* 2)
* Secretin
* Vasoactive intestinal peptide (1
* 2)

Class C: Metabotropic glutamate / pheromone

| Taste, sweet|

* TAS1R
* 1
* 2
* 3
* Vomeronasal receptor, type 2

|

Other|

* Calcium-sensing receptor
* GABAB (1
* 2)
* Glutamate receptor (Metabotropic glutamate (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8))
* GPRC6A
* GPR (156
* 158
* 179)
* RAIG (1
* 2
* 3
* 4)

Class F: Frizzled & Smoothened

| Frizzled|

* Frizzled (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10)

|

Smoothened|

* Smoothened

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