Brain-specific angiogenesis inhibitor 3

Protein-coding gene in the species Homo sapiens

ADGRB3

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

4DLO

Identifiers
Aliases| ADGRB3, BAI3, adhesion G protein-coupled receptor B3
External IDs| OMIM: 602684; MGI: 2441837; HomoloGene: 1289; GeneCards: ADGRB3; OMA:ADGRB3 - orthologs
| Gene location (Human)

Chr.| Chromosome 6 (human)[1]

Band| 6q12-q13| Start| 68,635,282 bp[1]
End| 69,390,571 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 1 (mouse)[2]

Band| 1|1 A5| Start| 25,106,557 bp[2]
End| 25,868,788 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* middle temporal gyrus

* endothelial cell

* Brodmann area 23

* ventricular zone

* orbitofrontal cortex

* superior frontal gyrus

* Brodmann area 46

* postcentral gyrus

* entorhinal cortex

* Region I of hippocampus proper

| Top expressed in

* lateral septal nucleus

* nucleus accumbens

* anterior amygdaloid area

* olfactory tubercle

* ventromedial nucleus

* lobe of cerebellum

* cerebellar vermis

* medial geniculate nucleus

* subiculum

* Region I of hippocampus proper

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* G protein-coupled receptor activity
* protein binding
* transmembrane signaling receptor activity
* signal transducer activity
* GTPase activator activity

Cellular component|

* integral component of membrane
* plasma membrane
* membrane
* postsynapse
* synaptic cleft
* intracellular anatomical structure
* integral component of plasma membrane

Biological process|

* negative regulation of angiogenesis
* G protein-coupled receptor signaling pathway
* positive regulation of GTPase activity
* cell surface receptor signaling pathway
* myoblast fusion
* signal transduction
* positive regulation of synapse assembly
* regulation of dendrite morphogenesis
* motor learning
* maintenance of synapse structure
* neuron remodeling
* adenylate cyclase-activating G protein-coupled receptor signaling pathway

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

577

210933

Ensembl| |

ENSG00000135298

ENSMUSG00000033569

UniProt| |

O60242

Q80ZF8

RefSeq (mRNA)| |

NM_001704

NM_175642

RefSeq (protein)| |

NP_001695

NP_783573

Location (UCSC)| Chr 6: 68.64 – 69.39 Mb| Chr 1: 25.11 – 25.87 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.[5][6]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[6] The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.[7]

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.[8] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135298 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033569 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenetics and Cell Genetics. 79 (1–2): 103–108\. doi:10.1159/000134693. PMID 9533023.1–2&rft.pages=103-108&rft.date=1998-04&rft_id=info:doi/10.1159/000134693&rft_id=info:pmid/9533023&rft.aulast=Shiratsuchi&rft.aufirst=T&rft.au=Nishimori,+H&rft.au=Ichise,+H&rft.au=Nakamura,+Y&rft.au=Tokino,+T&rfr_id=info:sid/en.wikipedia.org:Brain-specific+angiogenesis+inhibitor+3" class="Z3988">
6. ^ a b "Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3".
7. ^ Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, et al. (August 2013). "The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons". Molecular Psychiatry. 18 (8): 943–950\. doi:10.1038/mp.2013.46. PMC 3730300. PMID 23628982.943-950&rft.date=2013-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730300#id-name=PMC&rft_id=info:pmid/23628982&rft_id=info:doi/10.1038/mp.2013.46&rft.aulast=Lanoue&rft.aufirst=V&rft.au=Usardi,+A&rft.au=Sigoillot,+SM&rft.au=Talleur,+M&rft.au=Iyer,+K&rft.au=Mariani,+J&rft.au=Isope,+P&rft.au=Vodjdani,+G&rft.au=Heintz,+N&rft.au=Selimi,+F&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730300&rfr_id=info:sid/en.wikipedia.org:Brain-specific+angiogenesis+inhibitor+3" class="Z3988">
8. ^ Bolliger MF, Martinelli DC, Südhof TC (February 2011). "The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 108 (6): 2534–2539\. Bibcode:2011PNAS..108.2534B. doi:10.1073/pnas.1019577108. PMC 3038708. PMID 21262840.2534-2539&rft.date=2011-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038708#id-name=PMC&rft_id=info:pmid/21262840&rft_id=info:doi/10.1073/pnas.1019577108&rft_id=info:bibcode/2011PNAS..108.2534B&rft.aulast=Bolliger&rft.aufirst=MF&rft.au=Martinelli,+DC&rft.au=Südhof,+TC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038708&rfr_id=info:sid/en.wikipedia.org:Brain-specific+angiogenesis+inhibitor+3" class="Z3988">

## Further reading

[edit]

* Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106\. doi:10.1093/dnares/9.3.99. PMID 12168954.99-106&rft.date=2002-06&rft_id=info:doi/10.1093/dnares/9.3.99&rft_id=info:pmid/12168954&rft.aulast=Nakajima&rft.aufirst=D&rft.au=Okazaki,+N&rft.au=Yamakawa,+H&rft.au=Kikuno,+R&rft.au=Ohara,+O&rft.au=Nagase,+T&rft_id=https://doi.org/10.1093%2Fdnares%2F9.3.99&rfr_id=info:sid/en.wikipedia.org:Brain-specific+angiogenesis+inhibitor+3" class="Z3988">
* Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, et al. (February 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–39\. doi:10.1093/dnares/5.1.31. PMID 9628581.31-39&rft.date=1998-02&rft_id=info:doi/10.1093/dnares/5.1.31&rft_id=info:pmid/9628581&rft.aulast=Nagase&rft.aufirst=T&rft.au=Ishikawa,+K&rft.au=Miyajima,+N&rft.au=Tanaka,+A&rft.au=Kotani,+H&rft.au=Nomura,+N&rft.au=Ohara,+O&rft_id=https://doi.org/10.1093%2Fdnares%2F5.1.31&rfr_id=info:sid/en.wikipedia.org:Brain-specific+angiogenesis+inhibitor+3" class="Z3988">
* Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (July 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33\. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.23-33&rft.date=2004-07&rft_id=info:doi/10.1016/j.ygeno.2003.12.004&rft_id=info:pmid/15203201&rft.aulast=Bjarnadóttir&rft.aufirst=TK&rft.au=Fredriksson,+R&rft.au=Höglund,+PJ&rft.au=Gloriam,+DE&rft.au=Lagerström,+MC&rft.au=Schiöth,+HB&rfr_id=info:sid/en.wikipedia.org:Brain-specific+angiogenesis+inhibitor+3" class="Z3988">

## External links

[edit]

* Human ADGRB3 genome location and ADGRB3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

* v
* t
* e

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

| Neurotransmitter|

| Adrenergic|

* α1 (A
* B
* D)
* α2 (A
* B
* C)
* β1
* β2
* β3

|

Purinergic|

* Adenosine (A1
* A2A
* A2B
* A3)
* P2Y (1
* 2
* 4
* 5
* 6
* 8
* 9
* 10
* 11
* 12
* 13
* 14)

Serotonin|

* (all but 5-HT3) 5-HT1 (A
* B
* D
* E
* F)
* 5-HT2 (A
* B
* C)
* 5-HT (4
* 5A
* 6
* 7)

Other|

* Acetylcholine (M1
* M2
* M3
* M4
* M5)
* Dopamine
* D1
* D2
* D3
* D4
* D5
* GHB receptor
* Histamine
* H1
* H2
* H3
* H4
* Melatonin (1A
* 1B
* 1C)
* TAAR (1
* 2
* 5
* 6
* 8
* 9)

Metabolites and
signaling molecules|

| Eicosanoid|

* CysLT (1
* 2)
* LTB4
* 1
* 2
* FPRL1
* OXE
* Prostaglandin
* DP (1
* 2), EP (1
* 2
* 3
* 4), FP
* Prostacyclin
* Thromboxane

|

Other|

* Bile acid
* Cannabinoid (CB1
* CB2, GPR (18
* 55
* 119))
* EBI2
* Estrogen
* Free fatty acid (1
* 2
* 3
* 4)
* Hydroxycarboxylic acids
* 1
* 2
* 3
* Lysophosphatidic acid (1
* 2
* 3
* 4
* 5
* 6)
* Lysophospholipid (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8)
* Oxoglutarate
* PAF
* Sphingosine-1-phosphate (1
* 2
* 3
* 4
* 5)
* Succinate

Peptide|

| Neuropeptide|

* B/W (1
* 2)
* FF (1
* 2)
* S
* Y (1
* 2
* 4
* 5)
* Neuromedin (B
* U (1
* 2))
* Neurotensin (1
* 2)

|

Other|

* Anaphylatoxin (C3a
* C5a (1
* 2))
* Angiotensin (1
* 2)
* Apelin
* Bombesin
* BRS3
* GRPR
* NMBR)
* Bradykinin (B1
* B2)
* Chemokine
* Cholecystokinin (A
* B)
* Endothelin
* A
* B
* Formyl peptide (1
* 2
* 3)
* FSH
* Galanin (1
* 2
* 3)
* Gonadotropin-releasing hormone (1
* 2)
* Ghrelin
* Kisspeptin
* Luteinizing hormone/choriogonadotropin
* MAS (1
* 1L
* D
* E
* F
* G
* X1
* X2
* X3
* X4)
* Melanocortin (1
* 2
* 3
* 4
* 5)
* MCHR (1
* 2)
* Motilin
* Opioid (Delta
* Kappa
* Mu
* Nociceptin & Zeta, but not Sigma)
* Orexin (1
* 2)
* Oxytocin
* Prokineticin (1
* 2)
* Prolactin-releasing peptide
* Relaxin (1
* 2
* 3
* 4)
* Somatostatin (1
* 2
* 3
* 4
* 5)
* Tachykinin (1
* 2
* 3)
* Thyrotropin
* Thyrotropin-releasing hormone
* Urotensin-II
* Vasopressin (1A
* 1B
* 2)

Miscellaneous|

| Taste, bitter|

* TAS2R
* 1
* 3
* 4
* 5
* 7
* 8
* 9
* 10
* 13
* 14
* 16
* 19
* 20
* 30
* 31
* 38
* 39
* 40
* 41
* 42
* 43
* 45
* 46
* 50
* 60
* Vomeronasal receptor type 1

|

Orphan|

* GPR (1
* 3
* 4
* 6
* 12
* 15
* 17
* 18
* 19
* 20
* 21
* 22
* 23
* 25
* 26
* 27
* 31
* 32
* 33
* 34
* 35
* 37
* 39
* 42
* 44
* 45
* 50
* 52
* 55
* 61
* 62
* 63
* 65
* 68
* 75
* 78
* 81
* 82
* 83
* 84
* 85
* 87
* 88
* 92
* 101
* 103
* 109A
* 109B
* 119
* 120
* 132
* 135
* 137B
* 139
* 141
* 142
* 146
* 148
* 149
* 150
* 151
* 152
* 153
* 160
* 161
* 162
* 171
* 173
* 174
* 176
* 177
* 182
* 183)

Other|

* Adrenomedullin
* Olfactory
* Opsin (3
* 4
* 5
* 1LW
* 1MW
* 1SW
* RGR
* RRH)
* Protease-activated (1
* 2
* 3
* 4)
* SREB (1
* 2
* 3)

Class B: Secretin-like

| Adhesion|

* ADGRB
* Brain-specific angiogenesis inhibitor
* 1
* 2
* 3
* ADGRC
* Cadherin
* 1
* 2
* 3
* ADGRE
* EMR
* 1
* 2
* 3
* CD97
* ADGRG
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* ADGRL
* Latrophilin
* 1
* 2
* 3
* ELTD1

|

Orphan|

* GPR (56
* 64
* 97
* 98
* 110
* 111
* 112
* 113
* 114
* 115
* 116
* 123
* 124
* 125
* 126
* 128
* 133
* 143
* 144
* 155
* 157)

Other|

* Calcitonin
* CALCRL
* Corticotropin-releasing hormone (1
* 2)
* Glucagon (GR
* GIPR
* GLP1R
* GLP2R)
* Growth-hormone-releasing hormone
* PACAPR1
* GPR
* Methuselah-like proteins
* Parathyroid hormone (1
* 2)
* Secretin
* Vasoactive intestinal peptide (1
* 2)

Class C: Metabotropic glutamate / pheromone

| Taste, sweet|

* TAS1R
* 1
* 2
* 3
* Vomeronasal receptor, type 2

|

Other|

* Calcium-sensing receptor
* GABAB (1
* 2)
* Glutamate receptor (Metabotropic glutamate (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8))
* GPRC6A
* GPR (156
* 158
* 179)
* RAIG (1
* 2
* 3
* 4)

Class F: Frizzled & Smoothened

| Frizzled|

* Frizzled (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10)

|

Smoothened|

* Smoothened

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