CYP2W1

Protein-coding gene in the species Homo sapiens

CYP2W1

Identifiers
Aliases| CYP2W1, cytochrome P450 family 2 subfamily W member 1
External IDs| OMIM: 615967; MGI: 3616076; HomoloGene: 69239; GeneCards: CYP2W1; OMA:CYP2W1 - orthologs
| Gene location (Human)

Chr.| Chromosome 7 (human)[1]

Band| 7p22.3| Start| 983,181 bp[1]
End| 989,640 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 5 (mouse)[2]

Band| 5|5 G2| Start| 139,338,372 bp[2]
End| 139,342,788 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* buccal mucosa cell

* right adrenal cortex

* left adrenal cortex

* vena cava

* skin of abdomen

* skin of leg

* dorsal motor nucleus of vagus nerve

* internal globus pallidus

* sural nerve

* trabecular bone

| Top expressed in

* lip

* embryo

* zone of skin

* esophagus

* genital tubercle

* ileum

* colon

* stomach

* jejunum

* limb

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* iron ion binding
* oxidoreductase activity
* heme binding
* oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
* metal ion binding
* monooxygenase activity
* arachidonic acid epoxygenase activity
* steroid hydroxylase activity
* oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Cellular component|

* cell surface
* plasma membrane
* endoplasmic reticulum lumen
* endoplasmic reticulum membrane
* endoplasmic reticulum
* membrane
* cytoplasm
* intracellular membrane-bounded organelle

Biological process|

* xenobiotic metabolic process
* epoxygenase P450 pathway
* organic acid metabolic process

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

54905

545817

Ensembl| |

ENSG00000073067

ENSMUSG00000029541

UniProt| |

Q8TAV3

E9Q816

RefSeq (mRNA)| |

NM_017781

NM_001160265

RefSeq (protein)| |

NP_060251

NP_001153737

Location (UCSC)| Chr 7: 0.98 – 0.99 Mb| Chr 5: 139.34 – 139.34 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.[6] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073067 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029541 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Gerhard DS, Wagner L, Feingold EA, et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
6. ^ This article incorporates public domain material from "Entrez Gene: CYP2W1". Reference Sequence collection. National Center for Biotechnology Information.

## External links

[edit]

* Human CYP2W1 genome location and CYP2W1 gene details page in the UCSC Genome Browser.

## Further reading

[edit]

* Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Hanzawa Y, Sasaki T, Mizugaki M, et al. (2008). "Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population". Drug Metab. Dispos. 36 (2): 349–52. doi:10.1124/dmd.107.019141. PMID 17998294. S2CID 5123383.
* Yoshioka H, Kasai N, Ikushiro S, et al. (2006). "Enzymatic properties of human CYP2W1 expressed in Escherichia coli". Biochem. Biophys. Res. Commun. 345 (1): 169–74. doi:10.1016/j.bbrc.2006.04.080. PMID 16677611.
* Karlgren M, Gomez A, Stark K, et al. (2006). "Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1". Biochem. Biophys. Res. Commun. 341 (2): 451–8. doi:10.1016/j.bbrc.2005.12.200. PMID 16426568.
* Gomez A, Karlgren M, Edler D, et al. (2007). "Expression of CYP2W1 in colon tumors: regulation by gene methylation". Pharmacogenomics. 8 (10): 1315–25. doi:10.2217/14622416.8.10.1315. PMID 17979506.
* Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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* t
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Cytochromes, oxygenases: cytochrome P450 (Most belong to EC 1.14)

CYP1|

* A1
* A2
* A5
* B1

CYP2|

* A6
* A7
* A13
* B6
* C8
* C9
* C18
* C19
* D6
* E1
* F1
* J2
* R1
* S1
* U1
* W1

CYP3 (CYP3A)|

* A4
* A5
* A7
* A37
* A43

CYP4|

* A11
* A22
* B1
* F2
* F3
* F8
* F11
* F12
* F22
* V2
* X1
* Z1

CYP5-20|

* CYP5 (A1)
* CYP6 (G1, M2)
* CYP7 (A1, B1)
* CYP8 (A1, B1)
* CYP9
* CYP10
* CYP11 (A1, A2, B1, B2, B3, C1)
* CYP12
* CYP13
* CYP14
* CYP15
* CYP16
* CYP17 (A1)
* CYP18
* CYP19 (A1)
* CYP20 (A1)

CYP21-49|

* CYP21 (A2)
* CYP22 (A1)
* CYP23
* CYP24 (A1)
* CYP25
* CYP26 (A1, B1, C1)
* CYP27 (A1, B1, C1)
* CYP28 (A1)
* CYP29
* CYP35 (B1)
* CYP39 (A1)
* CYP46 (A1)

CYP51-69|

* CYP51 (A1, F1)
* CYP52
* CYP53
* A1
* CYP55
* A1
* CYP56
* A1
* CYP61

CYP71-99|

* CYP71 (C1, C2, C3, C4, Z6, AJ4, AV1, BA1)
* CYP72A1
* CYP73A1
* CYP74 (D1)
* CYP75 (A1, B1)
* CYP76 (B6, M7)
* CYP79 (A1, A2, B1, B2, B3, D1, D2, D3, D4)
* CYP80 (A1, B1, G2)
* CYP81 (E1, E3, E7, E9)
* CYP88D6
* CYP90C1
* CYP93E1
* CYP97C1
* CYP99A3

CYP101-281|

* CYP101A1
* CYP102A1
* CYP105
* A1
* D7
* CYP106A2
* CYP107
* A1
* G1
* CYP109
* B1
* E1
* CYP111
* CYP113A1
* CYP119A1
* CYP123
* CYP125A1
* CYP139
* CYP147
* CYP152
* A1
* B1
* CYP154C3
* CYP158A
* CYP161C
* CYP170
* A1
* B1
* CYP176A1
* CYP183A
* CYP197
* CYP199A2
* CYP255A

CYP301-499|

* CYP303A1
* CYP305
* M2
* Halloween genes ( CYP302A1, CYP306A1, CYP307A1, CYP307A2, CYP314A1, CYP315A1)
* CYP318A1

CYP501-699|

* CYP503
* CYP504B1

CYP701-999|

* CYP704B22
* CYP710
* CYP720A1

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