Calone

Chemical compound

Calone

Names
Preferred IUPAC name

7-Methyl-2,4-dihydro-3H-1,5-benzodioxepin-3-one

Other names

Calone 1951; Watermelon ketone; Methylbenzodioxepinone

Identifiers

CAS Number

* 28940-11-6 Y

3D model (JSmol)

* Interactive image

ChemSpider |

* 107218

ECHA InfoCard | 100.044.823

PubChem CID

* 120101

UNII |

* 0NQ136C313 Y

CompTox Dashboard (EPA)

* DTXSID0047165

InChI

* InChI=1/C10H10O3/c1-7-2-3-9-10(4-7)13-6-8(11)5-12-9/h2-4H,5-6H2,1H3

Key: SWUIQEBPZIHZQS-UHFFFAOYAC

SMILES

* O=C1COc2c(OC1)cc(cc2)C

Properties

Chemical formula

| C10H10O3
Molar mass | 178.187 g·mol−1
Appearance  | white crystals, flakes or clumps
Odor | distinctive
Melting point | 35–41 °C (95–106 °F; 308–314 K)
Hazards
Occupational safety and health (OHS/OSH):

Main hazards

| irritant

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

Chemical compound

Calone or methylbenzodioxepinone, trade-named Calone 1951, is an organic compound with the formula CH3C6H3(OCH2)2CO. A white solid, it is a derivative of 4-methylcatechol. In the fragrance industry it is known as "watermelon ketone".[1]

It was discovered by Pfizer in 1966. It is used to give the olfactory impression of a fresh seashore through the marine and ozone nuances. Calone is similar in structure to brown algae pheromones like ectocarpene and is also distantly related in structure to the benzodiazepine class of sedatives.[2]

Calone is an unusual chemical compound which has an intense "sea-breeze" note with slight floral and fruit overtones. It has been used as a scent component since the 1980s for its watery, fresh, ozone accords, and as a more dominant note in several perfumes of the marine trend, beginning in the 1990s. In 2014, Plummer et al. reported the synthesis and fragrance properties of several related aliphatic analogues.[3] Swiss company Firmenich later released CASCALONE®, a sweet, watery version of calone with a transparent floral signature.[4]

## References[edit]

1. ^ Panten, Johannes; Surburg, Horst (2016). "Flavors and Fragrances, 3. Aromatic and Heterocyclic Compounds". Ullmann's Encyclopedia of Industrial Chemistry. pp. 1–45. doi:10.1002/14356007.t11_t02. ISBN 978-3-527-30673-2.
2. ^ Yudov, Matvey. "Calone: The Air of the 1990s ~ Raw Materials ~ Fragrantica". fragrantica.com. Retrieved 29 June 2020.
3. ^ C. M. Plummer, R. Gericke, P. Kraft, A. Raynor, J. Froese, T. Hudlicky, T. J. Rook, O. A. H. Jones and H. M. Hϋgel (4 December 2014). "Synthesis of Saturated Benzodioxepinone Analogues: Insight into the Importance of the Aromatic Ring Binding Motif for Marine Odorants". Eur. J. Org. Chem. 2015 (3): 486–495. doi:10.1002/ejoc.201403142.`{{cite journal}}`: CS1 maint: multiple names: authors list (link)
4. ^ "CASCALONE®". www.firmenich.com. Retrieved 23 December 2023.

## External links[edit]

* Constituents of fragrances
* Watermelon ketone

*[CID]: Compound ID
*[EPA]: U.S. Environmental Protection Agency