Canine coronavirus

Species of virus

Canine coronavirus

Canine coronavirus antigen (arrows) in canine lung tissue
Virus classification
(unranked):  | Virus
Realm:  | Riboviria
Kingdom:  | Orthornavirae
Phylum:  | Pisuviricota
Class:  | Pisoniviricetes
Order:  | Nidovirales
Family:  | Coronaviridae
Genus:  | Alphacoronavirus
Subgenus:  | Tegacovirus
Species:  |

Alphacoronavirus suis

Virus:  |

Canine coronavirus

Strains[1]

* Canine coronavirus type I
* Canine coronavirus strain Elmo/02
* Canine coronavirus type II
* Canine coronavirus strain NTU336/F/2008

Canine coronavirus (CCoV) is an enveloped, positive-sense, single-stranded RNA virus which is a member of the species Alphacoronavirus suis. It is distributed world wide and may cause intestinal disease in dogs.[2] The infecting virus enters its host cell by binding to the APN receptor.[3] It was discovered in 1971 in Germany during an outbreak in sentry dogs.[2] The virus is a member of the genus Alphacoronavirus and subgenus Tegacovirus.[4]

## Canine enteric coronavirus

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### Pathology

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The virus invades and replicates in the villi of the small intestine. Intestinal disease may be related to virus-induced apoptosis (programmed cell death) of cells of the epithelial mucosa of the small intestine.[5] Canine coronavirus was originally thought to cause serious gastrointestinal disease, but now most cases are considered to be very mild or without symptoms.[6] A more serious complication of canine coronavirus occurs when the dog is also infected with canine parvovirus. Coronavirus infection of the intestinal villi makes the cells more susceptible to parvovirus infection. This causes a much more severe disease than either virus can separately.[7] However, fatal intestinal disease associated with canine coronavirus without the presence of canine parvovirus is still occasionally reported.[8][9] This may be related to the high mutation rate of RNA positive stranded viruses, of which canine coronavirus is one.[2]

### Symptoms, diagnosis, treatment, and control

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See also: DA2PPC vaccine

The incubation period is one to three days.[7] The disease is highly contagious and is spread through the feces of infected dogs, who usually shed the virus for six to nine days, but sometimes for six months following infection.[6] Symptoms include diarrhea, vomiting, and anorexia. Diagnosis is through detection of virus particles in the feces. Treatment usually only requires medication for diarrhea, but more severely affected dogs may require intravenous fluids for dehydration. Fatalities are rare. The virus is destroyed by most available disinfectants. There is a vaccine available (ATCvet code: QI07AD11 (WHO)), however, evidence suggests its use may be very limited to specific cases. It is generally not recommended for use, due to questions around its efficacy and the general timing of most vaccinations[10]. It was historically recommended in puppies and show dogs.[7]

## Canine respiratory coronavirus

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It has been suggested that parts of this page be moved into another existing article. (Discuss) (January 2022)

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Recently, a second type of canine coronavirus (Group II) has been shown to cause respiratory disease in dogs.[11] Known as canine respiratory coronavirus (CRCoV) and found to be similar to strain OC43 of bovine and human coronaviruses, it was first isolated in the United Kingdom in 2003 from lung samples of dogs[12] and has since been found on the European mainland[13] and in Japan.[14] A serological study in 2006 has also shown antibodies to CRCoV to be present in dogs in Canada and the United States.[15] However, a retrospective study in Saskatchewan found that CRCoV may have been present there as far back as 1996.[14]

## Human infection

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A study published on May 20, 2021, analyzed samples from eight patients with pneumonia (seven of whom were children) in hospitals of Sibu and Kapit, Malaysia, taken between 2017 and 2018 and found a novel coronavirus. This coronavirus is a species of Canine coronavirus (CCoV) which was named CCoV-HuPn-2018 and was found to have multiple similarities to feline coronavirus, swine transmissible gastroenteritis virus and some human and SARS-like coronaviruses. Most of these affect the spike protein and it is thought the virus could have undergone genetic recombination to achieve those traits. If this strain is confirmed to be associated with human disease then it would become the eighth known coronavirus to cause disease in humans.[16]

## References

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1. ^ "ICTV 9th Report (2011) Coronaviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 10 January 2019.
2. ^ a b c Pratelli A (2006). "Genetic evolution of canine coronavirus and recent advances in prophylaxis". Vet Res. 37 (2): 191–200\. doi:10.1051/vetres:2005053. PMID 16472519.
3. ^ Fehr AR, Perlman S (2015). "Coronaviruses: an overview of their replication and pathogenesis". In Maier HJ, Bickerton E, Britton P (eds.). Coronaviruses. Methods in Molecular Biology. Vol. 1282\. Springer. pp. 1–23\. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. PMC 4369385. PMID 25720466. "See Table 1."
4. ^ "Taxonomy browser (Canine coronavirus)". www.ncbi.nlm.nih.gov. Retrieved 1 March 2020.
5. ^ Ruggieri, A; Di Trani, L; Gatto, I; Franco, M; Vignolo, E; Bedini, B; Elia, G; Buonavoglia, C (2007). "Canine coronavirus induces apoptosis in cultured cells". Vet Microbiol. 121 (1–2): 64–72\. doi:10.1016/j.vetmic.2006.12.016. PMC 7117493. PMID 17254720.1–2&rft.pages=64-72&rft.date=2007&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117493#id-name=PMC&rft_id=info:pmid/17254720&rft_id=info:doi/10.1016/j.vetmic.2006.12.016&rft.aulast=Ruggieri&rft.aufirst=A&rft.au=Di+Trani,+L&rft.au=Gatto,+I&rft.au=Franco,+M&rft.au=Vignolo,+E&rft.au=Bedini,+B&rft.au=Elia,+G&rft.au=Buonavoglia,+C&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117493&rfr_id=info:sid/en.wikipedia.org:Canine+coronavirus" class="Z3988">
6. ^ a b Pratelli, A. (2005). "Canine Coronavirus Infection". Recent Advances in Canine Infectious Diseases. Archived from the original on 10 April 2005. Retrieved 25 June 2006.
7. ^ a b c Ettinger, Stephen J.; Feldman, Edward C. (1995). Textbook of Veterinary Internal Medicine (4th ed.). W.B. Saunders Company. ISBN 978-0-7216-6795-9.
8. ^ Evermann J, Abbott J, Han S (2005). "Canine coronavirus-associated puppy mortality without evidence of concurrent canine parvovirus infection". J Vet Diagn Invest. 17 (6): 610–4\. doi:10.1177/104063870501700618. PMID 16475526.
9. ^ Buonavoglia C, Decaro N, Martella V, Elia G, Campolo M, Desario C, Castagnaro M, Tempesta M (2006). "Canine coronavirus highly pathogenic for dogs". Emerg Infect Dis. 12 (3): 492–4\. doi:10.3201/eid1203.050839. PMC 3291441. PMID 16704791.
10. ^ Squires, R. A., Crawford, C., Marcondes, M., Whitley, N. (May 2024). "2024 guidelines for the vaccination of dogs and cats – compiled by the Vaccination Guidelines Group (VGG) of the World Small Animal Veterinary Association (WSAVA)". Journal of Small Animal Practice. 65 (5): 277–316\. doi:10.1111/jsap.13718. ISSN 0022-4510.
11. ^ Ellis, John A. (2006). "Outbreak! How can we approach emerging diseases?" (PDF). Proceedings of the North American Veterinary Conference. Archived from the original (PDF) on 29 September 2007. Retrieved 28 January 2007.
12. ^ Erles K, Toomey C, Brooks H, Brownlie J (2003). "Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease". Virology. 310 (2): 216–23\. doi:10.1016/S0042-6822(03)00160-0. PMC 7126160. PMID 12781709.
13. ^ Decaro N, Desario C, Elia G, Mari V, Lucente MS, Cordioli P, Colaianni ML, Martella V, Buonavoglia C (2006). "Serological and molecular evidence that canine respiratory coronavirus is circulating in Italy". Vet Microbiol. 121 (3–4): 225–30\. doi:10.1016/j.vetmic.2006.12.001. PMC 7117267. PMID 17215093.3–4&rft.pages=225-30&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117267#id-name=PMC&rft_id=info:pmid/17215093&rft_id=info:doi/10.1016/j.vetmic.2006.12.001&rft.aulast=Decaro&rft.aufirst=N&rft.au=Desario,+C&rft.au=Elia,+G&rft.au=Mari,+V&rft.au=Lucente,+MS&rft.au=Cordioli,+P&rft.au=Colaianni,+ML&rft.au=Martella,+V&rft.au=Buonavoglia,+C&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117267&rfr_id=info:sid/en.wikipedia.org:Canine+coronavirus" class="Z3988">
14. ^ a b Yachi A, Mochizuki M (2006). "Survey of dogs in Japan for group 2 canine coronavirus infection". J Clin Microbiol. 44 (7): 2615–8\. doi:10.1128/JCM.02397-05. PMC 1489469. PMID 16825396.
15. ^ Priestnall S, Brownlie J, Dubovi E, Erles K (2006). "Serological prevalence of canine respiratory coronavirus". Vet Microbiol. 115 (1–3): 43–53\. doi:10.1016/j.vetmic.2006.02.008. PMC 7117349. PMID 16551493.1–3&rft.pages=43-53&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117349#id-name=PMC&rft_id=info:pmid/16551493&rft_id=info:doi/10.1016/j.vetmic.2006.02.008&rft.aulast=Priestnall&rft.aufirst=S&rft.au=Brownlie,+J&rft.au=Dubovi,+E&rft.au=Erles,+K&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117349&rfr_id=info:sid/en.wikipedia.org:Canine+coronavirus" class="Z3988">
16. ^ Vlasova, A. N.; Diaz, A.; Damtie, D.; Xiu, L.; Toh, T. H.; Lee, J. S.; Saif, L. J.; Gray, G. C. (2021). "Novel Canine Coronavirus Isolated from a Hospitalized Pneumonia Patient, East Malaysia". Clinical Infectious Diseases. 74 (3): 446–454\. doi:10.1093/cid/ciab456. PMC 8194511. PMID 34013321.

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Taxonomy of the Coronaviridae

Higher taxonomy: Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae

Orthocoronavirinae

Alphacoronavirus|

| Colacovirus|

* Bat coronavirus CDPHE15

Decacovirus|

* Bat coronavirus HKU10
* Rhinolophus ferrumequinum alphacoronavirus HuB-2013

Duvinacovirus|

* Human coronavirus 229E

Luchacovirus|

* Lucheng Rn rat coronavirus

Minacovirus|

* Mink coronavirus 1

Minunacovirus|

* Miniopterus bat coronavirus 1
* Miniopterus bat coronavirus HKU8

Myotacovirus|

* Myotis ricketti alphacoronavirus Sax-2011

Nyctacovirus|

* Nyctalus velutinus alphacoronavirus SC-2013
* Pipistrellus kuhlii coronavirus 3398

Pedacovirus|

* Porcine epidemic diarrhea virus
* Scotophilus bat coronavirus 512

Rhinacovirus|

* Rhinolophus bat coronavirus HKU2

Setracovirus|

* Human coronavirus NL63
* NL63-related bat coronavirus strain BtKYNL63-9b

Soracovirus|

* Sorex araneus coronavirus T14

Sunacovirus|

* Suncus murinus coronavirus X74

Tegacovirus|

* Alphacoronavirus 1
* Feline coronavirus
* Canine coronavirus
* Canine coronavirus HuPn-2018
* Transmissible gastroenteritis virus

Betacoronavirus|

| Embecovirus|

* Betacoronavirus 1
* Bovine coronavirus
* Human coronavirus OC43
* China Rattus coronavirus HKU24
* Human coronavirus HKU1
* Murine coronavirus
* Rat coronavirus
* Myodes coronavirus 2JL14

Hibecovirus|

* Bat Hp-betacoronavirus Zhejiang2013

Merbecovirus|

* Hedgehog coronavirus 1
* Middle East respiratory syndrome-related coronavirus
* London1_novel CoV/2012
* MERS coronavirus EMC/2012
* Pipistrellus bat coronavirus HKU5
* Tylonycteris bat coronavirus HKU4

Nobecovirus|

* Eidolon bat coronavirus C704
* Rousettus bat coronavirus GCCDC1
* Rousettus bat coronavirus HKU9

Sarbecovirus|

* SARS-related coronavirus
* SARS-CoV-1
* SARS-CoV-2
* Variants
* BANAL-52
* Bat SARS-like coronavirus WIV1
* RacCS203
* RaTG13
* RmYN02
* RpYN06
* SHC014-CoV

Gammacoronavirus|

| Brangacovirus|

* Goose coronavirus CB17

Cegacovirus|

* Beluga whale coronavirus SW1

Igacovirus|

* Avian coronavirus
* Avian coronavirus 9203
* Duck coronavirus 2714

Deltacoronavirus|

| Andecovirus|

* Wigeon coronavirus HKU20

Buldecovirus|

* Bulbul coronavirus HKU11
* Common moorhen coronavirus HKU21
* Coronavirus HKU15
* Munia coronavirus HKU13
* White-eye coronavirus HKU16

Herdecovirus|

* Night heron coronavirus HKU19

Letovirinae

| Alphaletovirus|

| Milecovirus|

* Microhyla letovirus 1

Source: ICTV ––  Wikispecies

Taxon identifiers

Canine coronavirus|

* Wikidata: Q5032409
* NCBI: 11153

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