Carbonic anhydrase 7

Enzyme found in humans

CA7

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

3MDZ, 3ML5

Identifiers
Aliases| CA7, CAVII, carbonic anhydrase 7, CA-VII
External IDs| OMIM: 114770; MGI: 103100; HomoloGene: 55875; GeneCards: CA7; OMA:CA7 - orthologs
| Gene location (Human)

Chr.| Chromosome 16 (human)[1]

Band| 16q22.1| Start| 66,844,414 bp[1]
End| 66,854,153 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 8 (mouse)[2]

Band| 8|8 D3| Start| 105,261,321 bp[2]
End| 105,276,975 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* mucosa of transverse colon

* rectum

* mucosa of sigmoid colon

* testicle

* Brodmann area 10

* right frontal lobe

* Brodmann area 9

* putamen

* caudate nucleus

* cingulate gyrus

| Top expressed in

* yolk sac

* Paneth cell

* trigeminal ganglion

* facial motor nucleus

* substantia nigra

* cerebellar vermis

* lobe of cerebellum

* visual cortex

* Region I of hippocampus proper

* primary visual cortex

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* carbonate dehydratase activity
* zinc ion binding
* metal ion binding
* lyase activity
* carbonic anhydrase

Cellular component|

* cytoplasm
* cytosol

Biological process|

* bicarbonate transport
* positive regulation of cellular pH reduction
* positive regulation of synaptic transmission, GABAergic
* regulation of chloride transport

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

766

12354

Ensembl| |

ENSG00000168748

ENSMUSG00000031883

UniProt| |

P43166

Q9ERQ8

RefSeq (mRNA)| |

NM_001014435
NM_005182
NM_001365337

NM_001301164
NM_001301165
NM_053070

RefSeq (protein)| |

NP_001014435
NP_005173
NP_001352266

NP_001288093
NP_001288094
NP_444300

Location (UCSC)| Chr 16: 66.84 – 66.85 Mb| Chr 8: 105.26 – 105.28 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene.[5][6]

## Function

[edit]

Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.[6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168748 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031883 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Montgomery JC, Venta PJ, Eddy RL, Fukushima YS, Shows TB, Tashian RE (Dec 1991). "Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16" (PDF). Genomics. 11 (4): 835–48. doi:10.1016/0888-7543(91)90006-Z. hdl:2027.42/29017. PMID 1783392.
6. ^ a b "Entrez Gene: CA7 carbonic anhydrase VII".

## Further reading

[edit]

* Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annual Review of Biochemistry. 64: 375–401. doi:10.1146/annurev.bi.64.070195.002111. PMID 7574487.
* Rivera C, Voipio J, Kaila K (Jan 2005). "Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII". The Journal of Physiology. 562 (Pt 1): 27–36. doi:10.1113/jphysiol.2004.077495. PMC 1665491. PMID 15528236.
* Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
* Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E, Rasquin-Weber A, Hudson TJ, Richter A (Dec 2002). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". American Journal of Human Genetics. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
* Vullo D, Voipio J, Innocenti A, Rivera C, Ranki H, Scozzafava A, Kaila K, Supuran CT (Feb 2005). "Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides". Bioorganic & Medicinal Chemistry Letters. 15 (4): 971–6. doi:10.1016/j.bmcl.2004.12.052. PMID 15686895.

## External links

[edit]

* PDBe-KB provides an overview of all the structure information available in the PDB for Human Carbonic anhydrase 7

* v
* t
* e

Carbonic anhydrases

* CA1
* CA2
* CA3
* CA4
* CA5A
* CA5B
* CA6
* CA7
* CA8
* CA9
* CA10
* CA11
* CA12
* CA13
* CA14

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

|

* v
* t
* e

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template