Connective tissue nevus

Medical condition

Connective tissue nevus

Other names| Collagenoma, Elastoma, and Shagreen patch[1]
Storiform collagenoma, H&E stain
Specialty| Dermatology

A connective tissue nevus is a skin lesion which may be present at birth or appear within the first few years of life. It is elevated, soft to firm in consistency, varying in size from 0.5 to several centimeters in diameter, and may manifest as grouped, linear, or irregularly-distributed lesions.[2]: 993

## Signs and symptoms

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Connective tissue nevi are thickened regions of skin that look as a series of skin-colored papules and plaques. The spots will become discolored in a yellowish manner as the skin covering them is stretched. Occasionally, they could seem red and have enhanced vascularity.[3]

## Causes

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The majority of reports are of random lesions, but there are some familial cases, indicating autosomal dominant transmission.[4][5] Furthermore, connective tissue nevus can present as solitary lesions or be a component of systemic illnesses like tuberous sclerosis, which features shagreen's patches, another form of collagenoma, as an associated feature, or Buschke–Ollendorff syndrome, which is linked to collagenomas and elastomas.[6][7]

## Diagnosis

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In addition to hematoxylin-eosin staining to evaluate histological changes, lesion characteristics, genetic history, and special histochemical staining to highlight the composition of connective tissue nevus for differentiation, these tests are necessary for the diagnosis of connective tissue nevus.[8]

## See also

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* Skin lesion
* List of cutaneous conditions

## References

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1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
2. ^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
3. ^ Weston, William L.; Lane, Alfred T.; Morelli, Joseph G. (2007). "Skin Diseases in Newborns". Color Textbook of Pediatric Dermatology. Elsevier. p. 381–411. doi:10.1016/b978-0-323-04909-2.50024-2.
4. ^ Saussine, Anne; Marrou, Karine; Delanoé, Phillippe; Bodak, Nathalie; Hamel, Dominique; Picard, Arnaud; Sassolas, Bruno; de Prost, Yves; Lemerrer, Martine; Fraitag, Sylvie; Bodemer, Christine (2012). "Connective tissue nevi: An entity revisited". Journal of the American Academy of Dermatology. 67 (2). Elsevier BV: 233–239\. doi:10.1016/j.jaad.2011.08.008. ISSN 0190-9622.233-239&rft.date=2012&rft_id=info:doi/10.1016/j.jaad.2011.08.008&rft.issn=0190-9622&rft.aulast=Saussine&rft.aufirst=Anne&rft.au=Marrou,+Karine&rft.au=Delanoé,+Phillippe&rft.au=Bodak,+Nathalie&rft.au=Hamel,+Dominique&rft.au=Picard,+Arnaud&rft.au=Sassolas,+Bruno&rft.au=de+Prost,+Yves&rft.au=Lemerrer,+Martine&rft.au=Fraitag,+Sylvie&rft.au=Bodemer,+Christine&rfr_id=info:sid/en.wikipedia.org:Connective+tissue+nevus" class="Z3988">
5. ^ McCuaig, Catherine C.; Vera, Caridad; Kokta, Victor; Marcoux, Danielle; Hatami, Afshin; Thuraisingam, Thusanth; Marton, Dominique; Fortier-Riberdy, Geneviève; Powell, Julie (2012). "Connective tissue nevi in children: Institutional experience and review". Journal of the American Academy of Dermatology. 67 (5). Elsevier BV: 890–897\. doi:10.1016/j.jaad.2012.01.036. ISSN 0190-9622.890-897&rft.date=2012&rft_id=info:doi/10.1016/j.jaad.2012.01.036&rft.issn=0190-9622&rft.aulast=McCuaig&rft.aufirst=Catherine+C.&rft.au=Vera,+Caridad&rft.au=Kokta,+Victor&rft.au=Marcoux,+Danielle&rft.au=Hatami,+Afshin&rft.au=Thuraisingam,+Thusanth&rft.au=Marton,+Dominique&rft.au=Fortier-Riberdy,+Geneviève&rft.au=Powell,+Julie&rfr_id=info:sid/en.wikipedia.org:Connective+tissue+nevus" class="Z3988">
6. ^ Pope, V.; Dupuis, L.; Kannu, P.; Mendoza-Londono, R.; Sajic, D.; So, J.; Yoon, G.; Lara-Corrales, I. (2016-03-08). "Buschke–Ollendorff syndrome: a novel case series and systematic review". British Journal of Dermatology. 174 (4). Oxford University Press (OUP): 723–729\. doi:10.1111/bjd.14366. ISSN 0007-0963.723-729&rft.date=2016-03-08&rft_id=info:doi/10.1111/bjd.14366&rft.issn=0007-0963&rft.aulast=Pope&rft.aufirst=V.&rft.au=Dupuis,+L.&rft.au=Kannu,+P.&rft.au=Mendoza-Londono,+R.&rft.au=Sajic,+D.&rft.au=So,+J.&rft.au=Yoon,+G.&rft.au=Lara-Corrales,+I.&rfr_id=info:sid/en.wikipedia.org:Connective+tissue+nevus" class="Z3988">
7. ^ Arora, Harleen; Falto-Aizpurua, Leyre; Cortés-Fernandez, Andrea; Choudhary, Sonal; Romanelli, Paolo (2017). "Connective Tissue Nevi: A Review of the Literature". The American Journal of Dermatopathology. 39 (5). Ovid Technologies (Wolters Kluwer Health): 325–341\. doi:10.1097/dad.0000000000000638. ISSN 0193-1091.325-341&rft.date=2017&rft_id=info:doi/10.1097/dad.0000000000000638&rft.issn=0193-1091&rft.aulast=Arora&rft.aufirst=Harleen&rft.au=Falto-Aizpurua,+Leyre&rft.au=Cortés-Fernandez,+Andrea&rft.au=Choudhary,+Sonal&rft.au=Romanelli,+Paolo&rfr_id=info:sid/en.wikipedia.org:Connective+tissue+nevus" class="Z3988">
8. ^ Yang, Qingqing; Liu, Shengxiu (2022-10-25). "Connective tissue nevus—Isolated collagenoma". Skin Research and Technology. 28 (6). Wiley: 880–881\. doi:10.1111/srt.13210. ISSN 0909-752X. PMC 9907574.880-881&rft.date=2022-10-25&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907574#id-name=PMC&rft.issn=0909-752X&rft_id=info:doi/10.1111/srt.13210&rft.aulast=Yang&rft.aufirst=Qingqing&rft.au=Liu,+Shengxiu&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907574&rfr_id=info:sid/en.wikipedia.org:Connective+tissue+nevus" class="Z3988">

## Further reading

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* Tirelli, F.; Giraudo, C.; Soliani, M.; Calabrese, F.; Martini, G.; Gisondi, P.; Meneghel, A.; Zulian, Francesco (2023-10-17). "Connective tissue nevus misdiagnosed as juvenile localized scleroderma". Pediatric Rheumatology. 21 (1). Springer Science and Business Media LLC. doi:10.1186/s12969-023-00913-9. ISSN 1546-0096. PMC 10583392.
* Pierard, Gerald E.; Lapiere, Charles M. (1985). "Nevi of connective tissue A reappraisal of their classification". The American Journal of Dermatopathology. 7 (4). Ovid Technologies (Wolters Kluwer Health): 325–334\. doi:10.1097/00000372-198508000-00003. ISSN 0193-1091.325-334&rft.date=1985&rft_id=info:doi/10.1097/00000372-198508000-00003&rft.issn=0193-1091&rft.aulast=Pierard&rft.aufirst=Gerald+E.&rft.au=Lapiere,+Charles+M.&rfr_id=info:sid/en.wikipedia.org:Connective+tissue+nevus" class="Z3988">

## External links

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* DermNet
* VisualDx

Classification|

* ICD-11: LC20
* ICD-10: D23.9
* MeSH: C562737
* DiseasesDB: 31350
* SNOMED CT: 400091006

|

External resources|

* eMedicine: article/1056490
* Scholia: Q5161704

* v
* t
* e

Skin cancer of nevi and melanomas

Melanoma|

* Mucosal melanoma
* Superficial spreading melanoma
* Nodular melanoma
* lentigo
* Lentigo maligna/Lentigo maligna melanoma
* Acral lentiginous melanoma
* Amelanotic melanoma
* Desmoplastic melanoma
* Melanoma with features of a Spitz nevus
* Melanoma with small nevus-like cells
* Polypoid melanoma
* Nevoid melanoma
* Melanocytic tumors of uncertain malignant potential

Nevus/
melanocytic nevus|

* Nevus of Ito/Nevus of Ota
* Spitz nevus
* Pigmented spindle cell nevus
* Halo nevus
* Pseudomelanoma

* Blue nevus
* of Jadassohn–Tièche
* Cellular
* Epithelioid
* Deep penetrating
* Amelanotic
* Malignant

* Congenital melanocytic nevus (Giant
* Medium-sized
* Small-sized)

* Balloon cell nevus
* Dysplastic nevus/Dysplastic nevus syndrome

* Acral nevus
* Becker's nevus
* Benign melanocytic nevus
* Nevus spilus
* Connective tissue nevus

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