Cytochrome P450 BM3

Enzyme

Bifunctional cytochrome P450/NADPH--P450 reductase

Identifiers
Organism| Bacillus megaterium
Symbol| P450BM3
Alt. symbols| CYP102A1
PDB| 2IJ2
RefSeq (mRNA)| NZ_JJMH01000056.1
RefSeq (Prot)| WP_034650526.1
UniProt| P14779
Other data
EC number| 1.6.2.4
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Structures| Swiss-model
Domains| InterPro

Cytochrome P450 BM3 is a Prokaryote Cytochrome P450 enzyme originally from Bacillus megaterium catalyzes the hydroxylation of several long-chain fatty acids at the ω–1 through ω–3 positions. This bacterial enzyme belongs to CYP family CYP102, with the CYP Symbol CYP102A1.This CYP family constitutes a natural fusion between the CYP domain and an NADPH-dependent cytochrome P450 reductase.[1][2]

## References

[edit]

1. ^ Narhi LO, Fulco AJ (June 1986). "Characterization of a catalytically self-sufficient 119,000-dalton cytochrome P-450 monooxygenase induced by barbiturates in Bacillus megaterium". The Journal of Biological Chemistry. 261 (16): 7160–9\. doi:10.1016/S0021-9258(17)38369-2. PMID 3086309.7160-9&rft.date=1986-06&rft_id=info:doi/10.1016/S0021-9258(17)38369-2&rft_id=info:pmid/3086309&rft.aulast=Narhi&rft.aufirst=LO&rft.au=Fulco,+AJ&rft_id=http://www.jbc.org/cgi/pmidlookup?view=long&pmid;=3086309&rfr_id=info:sid/en.wikipedia.org:Cytochrome+P450+BM3" class="Z3988">
2. ^ Girvan HM, Waltham TN, Neeli R, Collins HF, McLean KJ, Scrutton NS, Leys D, Munro AW (December 2006). "Flavocytochrome P450 BM3 and the origin of CYP102 fusion species". Biochemical Society Transactions. 34 (Pt 6): 1173–7\. doi:10.1042/BST0341173. PMID 17073779.1173-7&rft.date=2006-12&rft_id=info:doi/10.1042/BST0341173&rft_id=info:pmid/17073779&rft.aulast=Girvan&rft.aufirst=HM&rft.au=Waltham,+TN&rft.au=Neeli,+R&rft.au=Collins,+HF&rft.au=McLean,+KJ&rft.au=Scrutton,+NS&rft.au=Leys,+D&rft.au=Munro,+AW&rfr_id=info:sid/en.wikipedia.org:Cytochrome+P450+BM3" class="Z3988">

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Cytochromes, oxygenases: cytochrome P450 (Most belong to EC 1.14)

CYP1|

* A1
* A2
* A5
* B1

CYP2|

* A6
* A7
* A13
* B6
* C8
* C9
* C18
* C19
* D6
* E1
* F1
* J2
* R1
* S1
* U1
* W1

CYP3 (CYP3A)|

* A4
* A5
* A7
* A37
* A43

CYP4|

* A11
* A22
* B1
* F2
* F3
* F8
* F11
* F12
* F22
* V2
* X1
* Z1

CYP5-20|

* CYP5 (A1)
* CYP6 (G1, M2)
* CYP7 (A1, B1)
* CYP8 (A1, B1)
* CYP9
* CYP10
* CYP11 (A1, A2, B1, B2, B3, C1)
* CYP12
* CYP13
* CYP14
* CYP15
* CYP16
* CYP17 (A1)
* CYP18
* CYP19 (A1)
* CYP20 (A1)

CYP21-49|

* CYP21 (A2)
* CYP22 (A1)
* CYP23
* CYP24 (A1)
* CYP25
* CYP26 (A1, B1, C1)
* CYP27 (A1, B1, C1)
* CYP28 (A1)
* CYP29
* CYP35 (B1)
* CYP39 (A1)
* CYP46 (A1)

CYP51-69|

* CYP51 (A1, F1)
* CYP52
* CYP53
* A1
* CYP55
* A1
* CYP56
* A1
* CYP61

CYP71-99|

* CYP71 (C1, C2, C3, C4, Z6, AJ4, AV1, BA1)
* CYP72A1
* CYP73A1
* CYP74 (D1)
* CYP75 (A1, B1)
* CYP76 (B6, M7)
* CYP79 (A1, A2, B1, B2, B3, D1, D2, D3, D4)
* CYP80 (A1, B1, G2)
* CYP81 (E1, E3, E7, E9)
* CYP88D6
* CYP90C1
* CYP93E1
* CYP97C1
* CYP99A3

CYP101-281|

* CYP101A1
* CYP102A1
* CYP105
* A1
* D7
* CYP106A2
* CYP107
* A1
* G1
* CYP109
* B1
* E1
* CYP111
* CYP113A1
* CYP119A1
* CYP123
* CYP125A1
* CYP139
* CYP147
* CYP152
* A1
* B1
* CYP154C3
* CYP158A
* CYP161C
* CYP170
* A1
* B1
* CYP176A1
* CYP183A
* CYP197
* CYP199A2
* CYP255A

CYP301-499|

* CYP303A1
* CYP305
* M2
* Halloween genes ( CYP302A1, CYP306A1, CYP307A1, CYP307A2, CYP314A1, CYP315A1)
* CYP318A1

CYP501-699|

* CYP503
* CYP504B1

CYP701-999|

* CYP704B22
* CYP710
* CYP720A1

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