DCHS2

Protein-coding gene in the species Homo sapiens

DCHS2

Identifiers
Aliases| DCHS2, CDH27, CDHJ, CDHR7, PCDH23, PCDHJ, dachsous cadherin-related 2
External IDs| OMIM: 612486; HomoloGene: 130686; GeneCards: DCHS2; OMA:DCHS2 - orthologs
| Gene location (Human)

Chr.| Chromosome 4 (human)[1]

Band| 4q31.3| Start| 154,231,742 bp[1]
End| 154,491,799 bp[1]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* prefrontal cortex

* Achilles tendon

* superior frontal gyrus

* nucleus accumbens

* smooth muscle tissue

* muscle layer of sigmoid colon

* sural nerve

* body of uterus

* myometrium

* caudate nucleus

n/a

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* calcium ion binding
* molecular function
* cadherin binding

Cellular component|

* integral component of membrane
* plasma membrane
* membrane
* cellular component

Biological process|

* cell adhesion
* homophilic cell adhesion via plasma membrane adhesion molecules
* biological process
* cell-cell adhesion

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

54798

n/a

Ensembl| |

ENSG00000197410
ENSG00000284227

n/a

UniProt| |

Q6V1P9

n/a

RefSeq (mRNA)| |

NM_001142552
NM_001142553
NM_017639
NM_199348
NM_001358235

n/a

RefSeq (protein)| |

NP_001136024
NP_001345164

n/a

Location (UCSC)| Chr 4: 154.23 – 154.49 Mb| n/a
PubMed search| [2]| n/a
Wikidata
| View/Edit Human|

|

Protein dachsous homolog 2, also known as protocadherin-23 (PCDH23) or cadherin-27 (CDH27), is a protein that in humans is encoded by the DCHS2 gene.[3][4]

DCHS2 has been implicated in the nose angle (how much a nose is upturned).[5] As well as facial genetics [6][7]

## References

[edit]

1. ^ a b c ENSG00000284227 GRCh38: Ensembl release 89: ENSG00000197410, ENSG00000284227 - Ensembl, May 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ "Entrez Gene: dachsous 2 (Drosophila)".
4. ^ Hoeng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, et al. (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". Journal of Molecular Biology. 337 (2): 307–317. doi:10.1016/j.jmb.2004.01.026. PMID 15003449.
5. ^ Adhikari K, Fuentes-Guajardo M, Quinto-Sánchez M, Mendoza-Revilla J, Camilo Chacón-Duque J, Acuña-Alonzo V, et al. (May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications. 7: 11616. Bibcode:2016NatCo...711616A. doi:10.1038/ncomms11616. PMC 4874031. PMID 27193062.
6. ^ Richmond S, Howe LJ, Lewis S, Stergiakouli E, Zhurov A (2018). "Facial Genetics: A Brief Overview". Frontiers in Genetics. 9: 462. doi:10.3389/fgene.2018.00462. PMC 6198798. PMID 30386375.
7. ^ Firger J (19 May 2016). "Your nose--Big or small--is shaped by your DNA". Newsweek.

## Further reading

[edit]

* Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
* Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
* Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

|

* v
* t
* e

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template