DEC1

Protein-coding gene in the species Homo sapiens

DELEC1

Identifiers
Aliases| DELEC1, CTS9, deleted in esophageal cancer 1, DEC1
External IDs| OMIM: 604767; GeneCards: DELEC1; OMA:DELEC1 - orthologs
| Gene location (Human)

Chr.| Chromosome 9 (human)[1]

Band| 9q33.1| Start| 114,850,968 bp[1]
End| 115,402,644 bp[1]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* testicle

* gonad

* granulocyte

* monocyte

* Achilles tendon

* sural nerve

* popliteal artery

* tibial arteries

* smooth muscle tissue

* stromal cell of endometrium

n/a

More reference expression data
BioGPS| |

More reference expression data
| Orthologs

Species| Human| Mouse
Entrez| |

50514

n/a

Ensembl| |

ENSG00000173077

n/a

UniProt| |

Q9P2X7

n/a

RefSeq (mRNA)| |

NM_017418

n/a

RefSeq (protein)| |

NP_059114

n/a

Location (UCSC)| Chr 9: 114.85 – 115.4 Mb| n/a
PubMed search| [2]| n/a
Wikidata
| View/Edit Human|

|

Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene.[3][4][5]

## Function

[edit]

The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas, associated with lymph node metastasis, and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas.[5]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173077 - Ensembl, May 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y (May 1996). "Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q". Cancer Res. 56 (7): 1629–34. PMID 8603412.
4. ^ Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y (Feb 2000). "Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32". Genes Chromosomes Cancer. 27 (2): 169–76. doi:10.1002/(SICI)1098-2264(200002)27:2<169::AID-GCC8>3.0.CO;2-M. PMID 10612805. S2CID 25576076.
5. ^ a b "Entrez Gene: DEC1 deleted in esophageal cancer 1".

## Further reading

[edit]

* Qian Y, Zhang J, Yan B, Chen X (2008). "DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence". J. Biol. Chem. 283 (5): 2896–905. doi:10.1074/jbc.M708624200. PMC 4118587. PMID 18025081.
* Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML (2008). "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma". Int. J. Cancer. 122 (3): 587–94. doi:10.1002/ijc.23144. PMID 17943723. S2CID 28437103.
* Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B (2006). "The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter". Oncogene. 25 (23): 3296–306. doi:10.1038/sj.onc.1209363. PMC 4114758. PMID 16462771.
* Preusser M, Birner P, Ambros IM, Ambros PF, Budka H, Harris AL, Hainfellner JA (2006). "DEC1 expression in 1p-aberrant oligodendroglial neoplasms". Histol. Histopathol. 20 (4): 1173–7. PMID 16136500.
* Yang L, Leung AC, Ko JM, Lo PH, Tang JC, Srivastava G, Oshimura M, Stanbridge EJ, Daigo Y, Nakamura Y, Tang CM, Lau KW, Law S, Lung ML (2005). "Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma". Oncogene. 24 (4): 697–705. doi:10.1038/sj.onc.1208179. PMID 15580306.
* Wong VC, Ko JM, Qi RZ, Li PJ, Wang LD, Li JL, Chan YP, Chan KW, Stanbridge EJ, Lung ML (Mar 1, 2011). "Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis". British Journal of Cancer. 104 (5): 841–9. doi:10.1038/bjc.2011.25. PMC 3048215. PMID 21326238.
* Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML (Feb 1, 2008). "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma". International Journal of Cancer. 122 (3): 587–94. doi:10.1002/ijc.23144. PMID 17943723. S2CID 28437103.

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