DOCK (protein)

Protein family

Dedicator of cytokinesis

Identifiers
Symbol| Ded_cyto
Pfam| PF06920
InterPro| IPR026791
SCOP2| 1wg7 / SCOPe / SUPFAM
CDD| cd11684
| Available protein structures:

Pfam | structures / ECOD
PDB| RCSB PDB; PDBe; PDBj
PDBsum| structure summary
PDB| 1wg7​

DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks.[1] DOCK family members contain a RhoGEF domain to function as guanine nucleotide exchange factors to promote GDP release and GTP binding to specific Small GTPases of the Rho family (e.g., Rac and Cdc42), leading to their activation since Rho proteins are inactive when bound to GDP but active when bound to GTP.

## Subfamilies

[edit]

DOCK family proteins are categorised into four subfamilies based on their sequence homology:

* DOCK-A subfamily
* Dock180 (also known as Dock1)
* Dock2
* Dock5
* DOCK-B subfamily
* Dock3 (also known as MOCA and PBP)
* Dock4
* DOCK-C subfamily (also known as Zir subfamily)
* Dock6 (also known as Zir1)
* Dock7 (also known as Zir2)
* Dock8 (also known as Zir3)
* DOCK-D subfamily (also known as Zizimin subfamily)
* Dock9 (also known as Zizimin1)
* Dock10 (also known as Zizimin3)
* Dock11 (also known as Zizimin2)

## References

[edit]

1. ^ Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". Journal of Cell Science. 115 (Pt 24): 4901–13\. doi:10.1242/jcs.00219. PMID 12432077.

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GTP-binding protein regulators

GTPase activating protein|

| Monomeric|

* Chimerin
* CHN1
* CHN2
* RasGAP
* NF1
* IQGAP
* Tuberous sclerosis protein
* TSC1
* TSC2

|

Heterotrimeric|

* Regulator of G protein signalling:
* RGS1
* RGS2
* RGS3
* RGS4
* RGS5
* RGS6
* RGS7
* RGS8
* RGS9
* RGS10
* RGS11
* RGS12
* RGS13
* RGS14
* RGS16
* RGS17
* RGS18
* RGS19
* RGS20
* RGS21

Guanine nucleotide exchange factor|

* EIF2B
* Son of Sevenless
* Ras-GRF1

RhoGEF|

| FGD|

* FGD1
* FGD2
* FGD3
* FGD4

|

DOCK|

* DOCK-A
* DOCK1
* Dock2
* Dock5
* DOCK-B
* Dock3
* Dock4
* DOCK-C
* Dock6
* Dock7
* Dock8
* DOCK-D
* Dock9
* Dock10
* Dock11

* ALS2
* SIL1
* IQSEC2

Other|

* Guanosine nucleotide dissociation inhibitors

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