Destrin

Protein found in humans

Destrin (actin binding protein)

Nuclear magnetic resonance determined configuration of the tertiary structure of Destrin.[1]

Identifiers
Symbol| DSTN
Alt. symbols| ADF
NCBI gene| 11034
HGNC| 15750
OMIM| 609114
RefSeq| NM_006870
UniProt| P60981
Other data
Locus| Chr. 20 p12.1
| Search for

Structures| Swiss-model
Domains| InterPro

Destrin or DSTN (also known as actin depolymerizing factor or ADF) is a protein which in humans is encoded by the DSTN gene.[2][3][4] Destrin is a component protein in microfilaments.

The product of this gene belongs to the actin-binding proteins ADF (Actin-Depolymerizing Factor)/cofilin family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.[2]

## Structure

[edit]

The tertiary structure of destrin was determined by the use of triple-resonance multidimensional nuclear magnetic resonance, or NMR for short.[1] The secondary and tertiary structures of destrin are similar to the gelsolin family which is another actin-regulating protein family.

There are three ordered layers to destrin which is a globular protein. There is a central β sheet that is composed of one parallel strand and three antiparallel strands. This β sheet is between a long α helix along with a shorter one and two shorter helices on the opposite side. The four helices are parallel to the β strands.[1]

## Function

[edit]

In a variety of eukaryotes, destrin regulates actin in the cytoskeleton. Destrin binds actin and is thought to connect it as gelsolin segment-1 does. Furthermore, the binding of actin by destrin and cofilin is regulated negatively by phosphorylation. Destrin can also sever actin filaments.[1]

## References

[edit]

1. ^ a b c d PDB: 1AK6​; Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F (June 1996). "Tertiary structure of destrin and structural similarity between two actin-regulating protein families". Cell. 85 (7): 1047–55\. doi:10.1016/S0092-8674(00)81305-7. PMID 8674111. S2CID 11470231.1047-55&rft.date=1996-06&rft_id=https://api.semanticscholar.org/CorpusID:11470231#id-name=S2CID&rft_id=info:pmid/8674111&rft_id=info:doi/10.1016/S0092-8674(00)81305-7&rft.aulast=Hatanaka&rft.aufirst=H&rft.au=Ogura,+K&rft.au=Moriyama,+K&rft.au=Ichikawa,+S&rft.au=Yahara,+I&rft.au=Inagaki,+F&rft_id=https://doi.org/10.1016%2FS0092-8674%2800%2981305-7&rfr_id=info:sid/en.wikipedia.org:Destrin" class="Z3988">
2. ^ a b "Entrez Gene: Destrin".
3. ^ Hawkins M, Pope B, Maciver SK, Weeds AG (September 1993). "Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments". Biochemistry. 32 (38): 9985–93\. doi:10.1021/bi00089a014. PMID 8399167.9985-93&rft.date=1993-09&rft_id=info:doi/10.1021/bi00089a014&rft_id=info:pmid/8399167&rft.aulast=Hawkins&rft.aufirst=M&rft.au=Pope,+B&rft.au=Maciver,+SK&rft.au=Weeds,+AG&rfr_id=info:sid/en.wikipedia.org:Destrin" class="Z3988">
4. ^ Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71\. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.865-71&rft.date=2001&rft_id=info:pmid/11780052&rft_id=info:doi/10.1038/414865a&rft_id=info:bibcode/2001Natur.414..865D&rft.aulast=Deloukas&rft.aufirst=P&rft.au=Matthews,+LH&rft.au=Ashurst,+J&rft_id=https://doi.org/10.1038%2F414865a&rfr_id=info:sid/en.wikipedia.org:Destrin" class="Z3988">

## External links

[edit]

* Destrin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
* Ramachandran Plot for destrin: "MolProbity Ramachandran analysis for 1ak6" (PDF). www.rcsb.org. Archived from the original (PDF) on 2012-10-12.

* v
* t
* e

Proteins of the cytoskeleton

Human|

| Microfilaments
and ABPs|

| Myofilament|

| Actins|

* A1
* A2
* B
* C1
* G1
* G2

|

Myosins|

* I
* MYO1A
* MYO1B
* MYO1C
* MYO1D
* MYO1E
* MYO1F
* MYO1G
* MYO1H)
* II
* MYH1
* MYH2
* MYH3
* MYH4
* MYH6
* MYH7
* MYH7B
* MYH8
* MYH9
* MYH10
* MYH11
* MYH13
* MYH14
* MYH15
* MYH16
* III
* MYO3A
* MYO3B
* V
* MYO5A
* MYO5B
* MYO5C
* VI
* MYO6
* VII
* MYO7A
* MYO7B
* IX
* MYO9A
* MYO9B
* X
* MYO10
* XV
* MYO15A
* XVIII
* MYO18A
* MYO18B
* LC
* MYL1
* MYL2
* MYL3
* MYL4
* MYL5
* MYL6
* MYL6B
* MYL7
* MYL9
* MYLIP
* MYLK
* MYLK2
* MYLL1

Other|

* Tropomodulin
* 1
* 2
* 3
* 4
* Troponin
* T 1 2 3
* C 1 2
* I 1 2 3
* Tropomyosin
* 1
* 2
* 3
* 4

* Actinin
* 1
* 2
* 3
* 4
* Arp2/3 complex
* actin depolymerizing factors
* Cofilin
* 1
* 2
* Destrin
* Gelsolin
* Profilin
* 1
* 2
* Titin

Other|

* Wiskott–Aldrich syndrome protein
* Fibrillin
* Filamin
* FLNA
* FLNB
* FLNC
* Espin
* TRIOBP

Intermediate
filaments|

| Type 1/2
(Keratin,
Cytokeratin)|

| Epithelial keratins
(soft alpha-keratins)|

* type I/chromosome 17
* 9
* 10
* 12
* 13
* 14
* 15
* 16
* 17
* 19
* 20
* chromosome 12
* 18
* none
* 21

* type II/chromosome 12
* 1
* 2A
* 3
* 4
* 5
* 6A
* 6B
* 6C
* 7
* 8

|

Hair keratins
(hard alpha-keratins)|

* type I/chromosome 17
* 31
* 32
* 33A
* 33B
* 34
* 35
* 36
* 37
* 38

* type II/chromosome 12
* 81
* 82
* 83
* 84
* 85
* 86

Ungrouped alpha|

* chromosome 17
* 23
* 24
* 25
* 26
* 27
* 28
* 39
* 40

* chromosome 12
* 71
* 72
* 73
* 74
* 75
* 76
* 77
* 78
* 79
* 80

Not alpha|

* Beta-keratin

Type 3|

* Desmin
* GFAP
* Peripherin
* Vimentin

Type 4|

* Internexin
* Nestin
* Neurofilament
* NEFL
* NEFM
* NEFH
* Synemin
* Syncoilin

Type 5|

* Nuclear lamins: A/C
* B1
* B2

Microtubules
and MAPs|

| Tubulins|

* TUBA1A
* TUBA1B
* TUBA1C
* TUBA3C
* TUBA3D
* TUBA3E
* TUBA4A
* TUBA8
* TUBB
* TUBB1
* TUBB2A
* TUBB2B
* TUBB2C
* TUBB3
* TUBB4
* TUBB4Q
* TUBB6
* TUBB8
* TUBG1
* TUBG2
* TUBGCP2
* TUBGCP3
* TUBGCP4
* TUBGCP5
* TUBGCP6
* TUBD1
* TUBE1

|

MAPs|

* EB1
* EB2
* EB3
* MAP1A
* MAP1B
* MAP2
* MAP4

Kinesins|

* KIF1A
* KIF1B
* KIF2A
* KIF2C
* KIF3B
* KIF3C
* KIF4A
* KIF4B
* KIF5A
* KIF5B
* KIF5C
* KIF6
* KIF7
* KIF9
* KIF11
* KIF12
* KIF13A
* KIF13B
* KIF14
* KIF15
* KIF16B
* KIF17
* KIF18A
* KIF18B
* KIF19
* KIF20A
* KIF20B
* KIF21A
* KIF21B
* KIF22
* KIF23
* KIF24
* KIF25
* KIF26A
* KIF26B
* KIF27
* KIFC1
* KIFC2
* KIFC3

Dyneins|

* axonemal: DNAH1
* DNAH2
* DNAH3
* DNAH5
* DNAH6
* DNAH7
* DNAH8
* DNAH9
* DNAH10
* DNAH11
* DNAH12
* DNAH13
* DNAH14
* DNAH17
* DNAI1
* DNAI2
* DNALI1
* DNAL1
* DNAL4

* cytoplasmic: DYNC1H1
* DYNC2H1
* DYNC1I1
* DYNC1I2
* DYNC1LI1
* DYNC1LI2
* DYNC2LI1
* DYNLL1
* DYNLL2
* DYNLRB1
* DYNLRB2
* DYNLT1
* DYNLT3

Microtubule organising proteins|

* CAMSAP1
* CAMSAP2
* CAMSAP3
* Centrin 1
* Centrin 2
* Centrin 3
* PCM1

Microtubule severing proteins|

* Katanin
* Spastin

Other|

* Tau protein
* Dynactin
* DCTN1
* Stathmin
* Tektin
* TEKT1
* TEKT2
* TEKT3
* TEKT4
* TEKT5
* Dynamin
* DNM1
* DNM2
* DNM3

Catenins|

* Alpha catenin
* Beta catenin
* APC
* Plakoglobin (gamma catenin)
* Delta catenin
* GAN

Membrane|

* Dystrophin
* Dystroglycan
* Utrophin
* Ankyrin
* ANK1
* ANK2
* ANK3
* Spectrin
* SPTA1
* SPTAN1
* SPTB
* SPTBN1
* SPTBN2
* SPTBN4
* SPTBN5

Other|

* Plakins
* Corneodesmosin
* Desmoplakin
* Dystonin
* Envoplakin
* MACF1
* Periplakin
* Plectin
* Talin
* TLN1
* Vinculin
* Plakophilin
* PKP1
* PKP2
* ACF7
* PLEKHA7

Nonhuman|

* Major sperm proteins
* Prokaryotic cytoskeleton
* Crescentin
* FtsZ
* MreB
* ParM

See also: cytoskeletal defects

This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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