E. Morton Jellinek

American biostatistician and physiologist (1890–1963

E. Morton Jellinek

Born| 15 August 1890

New York City, U.S.

Died| 22 October 1963 (1963-10-23) (aged 73)

Stanford, California, U.S.

Alma mater| University of Berlin
Known for| alcoholism research
Mother| Marcella Lindh (real name Rose Jellinek, née Jacobson)
Scientific career
Fields| biostatistics
Institutions|

* Stanford University
* Yale University

Elvin Morton "Bunky" Jellinek (15 August 1890 – 22 October 1963), E. Morton Jellinek, or most often, E. M. Jellinek, was an American biostatistician, physiologist, and an alcoholism researcher, fluent in nine languages and able to communicate in four others.

The son of Markus Erwin Marcel Jellinek (1858–1939) and Rose Jellinek (1867–1966), née Jacobson (a.k.a. the opera singer Marcella Lindh), he was born in New York City and died at the desk of his study at Stanford University on 22 October 1963.[1]

## Academic career

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Jellinek studied biostatistics and physiology at the University of Berlin from 1908 to 1910. He then studied philosophy, philology, anthropology, and theology for two years at the Joseph Fourier University in Grenoble. He was also enrolled, apparently concurrently, at the University of Leipzig from 25 November 1911 to 29 July 1913, and from 22 November 1913 to 2 December 1914 for classes in languages, linguistics and cultural history.[2]

During the 1920s, he conducted research in Sierra Leone and at Tela, Honduras. In the 1930s he returned to the U.S.A. and worked at the Worcester State Hospital, Worcester, Massachusetts, from whence he was commissioned to conduct a study for the Research Council on Problems of Alcohol. The eventual outcome of his study was the 1942 book, Alcohol Addiction and Chronic Alcoholism.

From 1941 to 1952, he was Associate Professor of Applied Physiology at Yale University. In 1941 he was managing editor of the newly established Quarterly Journal of Studies on Alcohol (now the Journal of Studies on Alcohol and Drugs).[3] In 1950 he was engaged by the World Health Organization in Geneva as a consultant on alcoholism, and made significant contributions to the work of the Alcoholism Sub-committee of the WHO's Expert Committee on Mental Health.

The Second Report of the Alcoholism Subcommittee, published in August 1952, have reproduced in its 2nd Annex, the text of an important communication that Jellinek gave to the first European Seminar on Alcoholism in Copenhagen in October 1951.

In that conference, he exposed his work on the Phases of alcoholic addiction and he presented a detailed Chart (page 30) exposing the progressive nature of alcoholism. That chart is considered as the 1st version of the future Jellinek's Curve that some other people, including Max Glatt, would eventually draw from his work.[4]

Upon his retirement from the WHO in the late 1950s, he returned to the USA. In 1958 he joined the Psychiatry Schools of both the University of Toronto and the University of Alberta, and in 1962, he moved to Stanford University in California, where he remained until his death.[5]

## Works

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Addiction researcher Griffith Edwards (2002, p. 98) holds that, in his opinion, Jellinek's The Disease Concept of Alcoholism was a work of outstanding scholarship based on a careful consideration of the available evidence.

### Disease concept of alcoholism

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Main article: Disease theory of alcoholism

In 1849, the Swedish physician Magnus Huss (1807–1890)[6] was the first to systematically classify the damage that was attributable to alcohol ingestion. Huss coined the term alcoholism and used it to label what he considered to be a chronic, relapsing disease.[7]

Jellinek coined the expression "the disease concept of alcoholism",[8] and significantly accelerated the movement towards the medicalization of drunkenness and alcohol habituation.

Jellinek’s initial 1946 study was funded by Marty Mann[9] and R. Brinkley Smithers[10] (Falcone, 2003). It was based on a narrow, selective study of a hand-picked group of members of Alcoholics Anonymous (AA) who had returned a self-reporting questionnaire.[11] Valverde opines that a biostatistician of Jellinek’s eminence would have been only too well aware of the "unscientific status" of the "dubiously scientific data that had been collected by AA members".[12]

In his 1960 book he identified five different types of alcoholism, and defined them in terms of their abnormal physiological processes:

In order to differentiate alcoholism not just diachronically, along a time line but also synchronically across groups of people, thus distinguishing types of alcoholics in a way that ran quite counter to the AA emphasis on the unity of all alcoholics, Jellinek came up with the idea of grouping different drinking patterns and naming them by giving each a Greek letter. One might think that the purpose of such a classification is to expand the range of alcoholism and include as many people as possible under the "disease concept"; but, contrary to what the title suggests, Jellinek's 1960 magnum opus in fact tries to limit the scope of the "disease concept", stating that most of the types described might be alcoholics, but they are not diseased – because they do not suffer from "loss of control".[13]

* Alpha alcoholism: the earliest stage of the disease, manifesting the purely psychological continual dependence on the effects of alcohol to relieve bodily or emotional pain. This is the "problem drinker", whose drinking creates social and personal problems. Whilst there are significant social and personal problems, these people can stop if they really want to; thus, argued Jellinek, they have not lost control, and as a consequence, do not have a "disease".
* Beta alcoholism: polyneuropathy, or cirrhosis of the liver from alcohol without physical or psychological dependence. These are the heavy drinkers that drink a lot, almost every day. They do not have physical addiction and do not suffer withdrawal symptoms. This group do not have a "disease".
* Gamma alcoholism: involving acquired tissue tolerance, physical dependence, and loss of control. This is the AA alcoholic, who is very much out of control, and does, by Jellinek's classification, have a "disease".[14]
* Delta alcoholism: as in Gamma alcoholism, but with inability to abstain, instead of loss of control.
* Epsilon alcoholism: the most advanced stage of the disease, manifesting as dipsomania, or periodic alcoholism.

While Jellinek's classification draws a clear (if arbitrary) line between the garden-variety alcoholic and the truly diseased alcoholic, it does not draw such a clear boundary between alcoholism in general and normal drinking. This is Jellinek's Achilles' heel . . .
By relying on cultural norms to define several of his types, he implicitly gives up the project of providing a single, objective, universally valid clinical definition of alcoholism, and opens the door to anthropological nominalistic definitions along the lines of "whatever is normal drinking in that particular culture is normal drinking". (Valverde, 1998, p.112)

The "Jellinek curve"[15] is derived from this classification of Jellinek, and it was named out of respect for Jellinek’s work.[16] Jellinek later completely dissociated himself from this chart's representations; however it is still known as the "Jellinek curve".

### Recognition of placebo effect

[edit]

Main article: Placebo

In post-war 1946, various pharmaceutical chemicals were in short supply for making medicines. A headache remedy manufacturer found that supplies of one of its remedy’s three constituent chemicals was running out.

They asked Jellinek, then at Yale, to test whether the absence of that particular chemical would affect the drug’s efficacy in any way. Jellinek set up a complex trial – with 199 subjects, divided randomly into four test groups – involving various permutations of the three drug constituents, with a placebo as a scientific control. Each group took a test remedy for two weeks at a time. The trial lasted eight weeks, by the end of which each group had taken each of the test drugs, albeit in a different sequence. Over the entire population of 199 subjects, 120 of the subjects (~60%) responded to the placebo, and 79 did not. The trial also demonstrated that the chemical in question significantly contributed to the remedy's efficacy.

In the process of examining the data produced by his trial, Jellinek discovered that there was a significant difference in responses to the active chemicals between the 120 who had responded to the placebo and the 79 who did not. He (1946, p. 90) described the former group as being "reactors to placebo", and this seems to be the first time that anyone had spoken of either "placebo reactions" or "placebo responses".[17]

## Jellinek Award

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The Jellinek Memorial Award, or Jellinek Award, is an award presented annually by the Jellinek Memorial Fund in Jellinek's honor. It is given to a scientist who has made an outstanding contribution to research on alcohol or alcoholism. Winners receive a cash prize of US$5,000, as well as a bust of Jellinek with a personalized inscription.[18]

## Selected publications

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* Haggard, H. W. & Jellinek, E. M., Alcohol Explored, Doubleday, Doran & Company, Inc., (Garden City), 1942.
* Jellinek, E. M. (ed), Alcohol Addiction and Chronic Alcoholism, Yale University Press, (New Haven), 1942.
* Jellinek, E. M. "Clinical Tests on Comparative Effectiveness of Analgesic Drugs", Biometrics Bulletin, Vol.2, No.5, (October 1946), pp. 87–91. doi:10.2307/3001983
* Jellinek, E. M., "Phases in the Drinking History of Alcoholics: Analysis of a Survey Conducted by the Official Organ of Alcoholics Anonymous", Quarterly Journal of Studies on Alcohol, Vol.7, (1946), pp. 1–88. doi:10.15288/QJSA.1946.7.1
* Jellinek, E. M., The Disease Concept of Alcoholism, Hillhouse, (New Haven), 1960.

## See also

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* Akrasia
* Alcoholics Anonymous
* Disease model of addiction
* Drug tolerance
* Placebo (origins of technical term)
* Selden D. Bacon

## Notes

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1. ^ Bahariahtas, 2014.
2. ^ Page, 1997.
3. ^ "About the Journal". Center of Alcohol Studies, Rutgers University. Archived from the original on 3 January 2013. Retrieved 9 September 2010.
4. ^ Kamilla L. Venner., Sarah W. Feldstein (2006). "Natural History of Alcohol Dependence and Remission Events for a Native American Sample". Journal of Studies on Alcohol. 67 (5): 675–684\. doi:10.15288/jsa.2006.67.675. PMC 2911362. PMID 16847535.
5. ^ For more information, see 1964 obituary in The American Journal of Psychiatry [1]
6. ^ He was physician to the Swedish kings Charles XIV and Oscar I.
7. ^ The term first appeared (in 1849) in the Swedish edition of Alcoholismus Chronicus, or Chronic Alcohol Illness. A Contribution to the Study of Dyscrasias Based on my Personal Experience and the Experience of Others, which was soon translated to German (1852) and later into English.
8. ^ It also appears as the title of his 1960 book, The Disease Concept of Alcoholism.
9. ^ Marty Mann (1905–1980), an early female member of Alcoholics Anonymous
10. ^ In his lifetime, R. Brinkley Smithers (1907–1994) – an American philanthropist, and founder of the Christopher D. Smithers Foundation, which had been named after his father, an IBM founder (via the Computing-Tabulating-Recording Company), and a Director of IBM (1913–1952) – a self-styled "recovering alcoholic", donated more than $US40 million to alcoholism programs; $US13.5 million through the Smithers Foundation, and $US28 million from his own his personal funds.(Peele [2])
11. ^ Of the 158 questionnaires returned, Marty Mann selected 98; and it was upon this hand-picked population that Jellinek’s reported in his 1946 study.
12. ^ Valverde (1998), pp.110–111; Valverde also noted that the AA questionnaire that was the source for Jellinek's classification only had relevance to "the experience of white, male, middle-class alcoholics in the 1940s" (p.110).
13. ^ Valverde, 1998, p.111.
14. ^ "It is characterized by binge drinking and a slow downward slide into helplessness"(Valverde, 1998, p.112).
15. ^ "Archived copy" (PDF). Archived from the original (PDF) on 1 August 2014. Retrieved 20 July 2012.`{{cite web}}`: CS1 maint: archived copy as title (link)
16. ^ William E. Swegan, 2. The Psychology of Alcoholism
17. ^ This is 10 years prior to Beecher's 1955 paper, "The Powerful Placebo", which is commonly and incorrectly named as the source of the term; see: Placebo (origins of technical term).
18. ^ "About Us". Jellinek Memorial Awards. Archived from the original on 18 October 2017. Retrieved 17 October 2017.

## References

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* Archibald, H.D., "Dr. Elwin [sic] Morton Jellinek: (1891–1964)", American Journal of Psychiatry, Vol.120, (June 1964), pp. 1217–1218. (Jellinek's obituary)
* Beecher, H.K., "The Powerful Placebo", Journal of the American Medical Association, Vol.159, No.17, (24 December 1955), pp. 1602–1606.
* Edwards, G., Alcohol: The World's Favourite Drug. 1st US ed. Thomas Dunne Books: 2002. ISBN 0-312-28387-3.
* Falcone, T.J., "Alcoholism: A Disease of Speculation", Baldwin Research Institute, 2003. [3] Archived 8 August 2019 at the Wayback Machine
* Greenberg, G., "The Creation of Disease", The New Yorker, April 20, 2013.
* Jellinek, E. M., The Disease Concept of Alcoholism, Hillhouse, (New Haven), 1960.
* Levine, H.G., "The Discovery of Addiction: Changing Conceptions of Habitual Drunkenness in America", Journal of Studies on Alcohol, Vol.39, No.1, (January 1978), pp. 143–174. (Reprint: Journal of Substance Abuse Treatment, Vol.2, No.1, (1985), pp. 43–57.) Available at [4]
* Page, P.B., "E. M. Jellinek and the Evolution of Alcohol Studies: A Critical Essay", Addiction, Vol.92, No.12, (December 1997), pp. 1619–1637.
* Peele, S., "R. Brinkley Smithers: The Financier of the Modern Alcoholism Movement", The Stanton Peele Addiction Website, (not dated), retrieved from [5] on 18 June 2006.
* Ribot, T. (Snell, M. trans.), The Diseases of the Will: Authorised Translation from the Eighth French Edition, The Open Court Publishing Company, (Chicago), 1894.
* Rush, B., An Inquiry into the Effects of Ardent Spirits upon the Human Body and Mind: With an Account of the Means of Preventing, and of the Remedies for Curing Them, Thomas Dobson, (Philadelphia), 1808.
* Taylor, C.C.W., Plato: Protagoras, Clarendon Press, (Oxford), 1976. ISBN 0-19-872045-9
* Trotter, T. (Porter, R., ed.), An Essay, Medical, Philosophical, and Chemical, on Drunkenness and Its Effects on the Human Body, Routledge, (London), 1988. (This a facsimile of the first (1804) London edition. The book itself was based on the thesis "De ebrietate, ejusque effectibus in corpus humanum" that Trotter had presented to Edinburgh University in 1788.)
* Valverde, M., Diseases of the Will: Alcohol and the Dilemmas of Freedom, Cambridge University Press, (Cambridge), 1998.
* Ward, J.H., Bejarano, W., Babor, T.F., and Allred, N., "Re-Introducing Bunky at 125: E. M. Jellinek’s Life and Contributions to Alcohol Studies", Journal of Studies on Alcohol and Drugs, Vol.77, No.3, (May 2016), pp.375-383.

### 36th Annual SALIS Conference

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Substance Abuse Library and Information Studies: Proceedings of the 36th Annual SALIS Conference, (May 1, 2014).

* Bejarano, W., "Mystery and Speculations: An Introduction to E.M. Jellinek’s Redemption", Substance Abuse Library and Information Studies: Proceedings of the 36th Annual SALIS Conference, (May 1, 2014), pp.33-41.
* Ward, J.H., "E.M. Jellinek: The Hungarian Connection", Substance Abuse Library and Information Studies: Proceedings of the 36th Annual SALIS Conference, (May 1, 2014), pp.42-54.
* Bariahtaris, C., "The Family of E. M. Jellinek: Documenting a History", Substance Abuse Library and Information Studies: Proceedings of the 36th Annual SALIS Conference, (May 1, 2014), pp.55-61.
* Goldstein, S., "The "Banana Book" by E.M. Jellinek", Substance Abuse Library and Information Studies: Proceedings of the 36th Annual SALIS Conference, (May 1, 2014), pp.62-66.
* Thomas, K., "E. M. Jellinek: The Worcester Hospital Years (1930-1939)", Substance Abuse Library and Information Studies: Proceedings of the 36th Annual SALIS Conference, (May 1, 2014), pp.67-72.
* Stewart, M., "Mark Keller and E.M. Jellinek", Substance Abuse Library and Information Studies: Proceedings of the 36th Annual SALIS Conference, (May 1, 2014), pp.73-77.
* Roizen, R., "The Jellinek Project: Summing Up, So Far", Substance Abuse Library and Information Studies: Proceedings of the 36th Annual SALIS Conference, (May 1, 2014), pp.78-82.

## External links

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* Works by or about E. Morton Jellinek at the Internet Archive
* 1964 obituary, The American Journal Of Psychiatry.
* Controversy over Jellinek’s true academic status.
* Roizen's Lecture to 2000 Annual Meeting of the Alcoholic Beverage Medical Research Foundation now (ABMRF)The Foundation for Alcohol Research.
* Origins of the Alcoholics Anonymous "Jellinek Curve".
* "Jellinek Curve". Archived 1 August 2014 at the Wayback Machine
* Alcoholism: A disease of speculation (criticism of Jellinek's work, and the veracity of the concept of alcoholism as a disease). Archived 8 August 2019 at the Wayback Machine
* A comprehensive bibliography of E. M. Jellinek’s publications. Journal of Studies on Alcohol and Drugs.

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