EDEM1

Protein-coding gene in the species Homo sapiens

EDEM1

Identifiers
Aliases| EDEM1, EDEM, ER degradation enhancing alpha-mannosidase like protein 1
External IDs| OMIM: 607673; MGI: 2180139; HomoloGene: 33836; GeneCards: EDEM1; OMA:EDEM1 - orthologs
| Gene location (Human)

Chr.| Chromosome 3 (human)[1]

Band| 3p26.1| Start| 5,187,646 bp[1]
End| 5,219,958 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 6 (mouse)[2]

Band| 6|6 E2| Start| 108,805,602 bp[2]
End| 108,836,317 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* bone marrow cells

* thymus

* liver

* right lobe of liver

* lymph node

* epithelium of nasopharynx

* decidua

* appendix

* tonsil

* stromal cell of endometrium

| Top expressed in

* lacrimal gland

* thymus

* parotid gland

* stroma of bone marrow

* crypt of lieberkuhn of small intestine

* left lobe of liver

* granulocyte

* decidua

* submandibular gland

* islet of Langerhans

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* calcium ion binding
* misfolded protein binding
* mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
* protein binding
* catalytic activity

Cellular component|

* integral component of membrane
* endoplasmic reticulum membrane
* membrane
* integral component of endoplasmic reticulum membrane
* endoplasmic reticulum
* endoplasmic reticulum quality control compartment
* Golgi membrane
* aggresome

Biological process|

* N-glycan processing
* positive regulation of retrograde protein transport, ER to cytosol
* trimming of terminal mannose on C branch
* IRE1-mediated unfolded protein response
* response to unfolded protein
* ubiquitin-dependent glycoprotein ERAD pathway
* mannose trimming involved in glycoprotein ERAD pathway
* ubiquitin-dependent ERAD pathway

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

9695

192193

Ensembl| |

ENSG00000134109

ENSMUSG00000030104

UniProt| |

Q92611

Q925U4

RefSeq (mRNA)| |

NM_014674

NM_138677

RefSeq (protein)| |

NP_055489

NP_619618

Location (UCSC)| Chr 3: 5.19 – 5.22 Mb| Chr 6: 108.81 – 108.84 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene.[5][6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134109 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030104 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Molinari M, Calanca V, Galli C, Lucca P, Paganetti P (Feb 2003). "Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle". Science. 299 (5611): 1397–400. doi:10.1126/science.1079474. PMID 12610306. S2CID 24092303.
6. ^ "Entrez Gene: EDEM1 ER degradation enhancer, mannosidase alpha-like 1".

## Further reading

[edit]

* Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
* Hosokawa N, Wada I, Hasegawa K, et al. (2001). "A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation". EMBO Rep. 2 (5): 415–22. doi:10.1093/embo-reports/kve084. PMC 1083879. PMID 11375934.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Oda Y, Hosokawa N, Wada I, Nagata K (2003). "EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin". Science. 299 (5611): 1394–7. doi:10.1126/science.1079181. PMID 12610305. S2CID 28716209.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Olivari S, Galli C, Alanen H, et al. (2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J. Biol. Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
* Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
* Hosokawa N, Wada I, Natsuka Y, Nagata K (2006). "EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsin". Genes Cells. 11 (5): 465–76. doi:10.1111/j.1365-2443.2006.00957.x. PMID 16629899. S2CID 19832510.
* Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
* Zuber C, Cormier JH, Guhl B, et al. (2007). "EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites". Proc. Natl. Acad. Sci. U.S.A. 104 (11): 4407–12. Bibcode:2007PNAS..104.4407Z. doi:10.1073/pnas.0700154104. PMC 1810509. PMID 17360537.

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