ENAH (gene)

Protein-coding gene in the species Homo sapiens

ENAH

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

2HO2, 2IYB, 2XQN, 4MY6

Identifiers
Aliases| ENAH, ENA, MENA, NDPP1, enabled homolog (Drosophila), actin regulator
External IDs| OMIM: 609061; MGI: 108360; HomoloGene: 134005; GeneCards: ENAH; OMA:ENAH - orthologs
| Gene location (Human)

Chr.| Chromosome 1 (human)[1]

Band| 1q42.12| Start| 225,486,835 bp[1]
End| 225,653,142 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 1 (mouse)[2]

Band| 1 H5|1 84.93 cM| Start| 181,723,949 bp[2]
End| 181,847,555 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* saphenous vein

* epithelium of colon

* secondary oocyte

* vena cava

* urethra

* seminal vesicula

* cardia

* ventricular zone

* Achilles tendon

* Skeletal muscle tissue of rectus abdominis

| Top expressed in

* vestibular membrane of cochlear duct

* Rostral migratory stream

* ascending aorta

* seminal vesicula

* stria vascularis

* vestibular sensory epithelium

* genital tubercle

* tail of embryo

* medullary collecting duct

* aortic valve

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* SH3 domain binding
* WW domain binding
* actin binding
* protein binding
* profilin binding

Cellular component|

* filopodium
* cell junction
* plasma membrane
* cell projection
* synapse
* cytoskeleton
* focal adhesion
* lamellipodium
* cytoplasm
* cytosol

Biological process|

* axon guidance
* actin polymerization or depolymerization
* actin polymerization-dependent cell motility

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

55740

13800

Ensembl| |

ENSG00000154380

ENSMUSG00000022995

UniProt| |

Q8N8S7

Q03173

RefSeq (mRNA)| |

NM_001008493
NM_018212

NM_001083120
NM_001083121
NM_008680
NM_010135

RefSeq (protein)| |

NP_001008493
NP_060682
NP_001364410
NP_001364411
NP_001364412

NP_001076589
NP_001076590
NP_032706
NP_034265

Location (UCSC)| Chr 1: 225.49 – 225.65 Mb| Chr 1: 181.72 – 181.85 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Protein enabled homolog is a protein that in humans is encoded by the ENAH gene.[5][6]

## Interactions

[edit]

ENAH has been shown to interact with ABI1,[7] ZYX,[7][8] and PCARE.[9]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154380 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022995 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M, Kumar S (October 1992). "Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1132 (3): 240–248\. doi:10.1016/0167-4781(92)90156-t. hdl:2027.42/29785. PMID 1420303.
6. ^ "Entrez Gene: ENAH enabled homolog (Drosophila)".
7. ^ a b Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". The Journal of Biological Chemistry. 278 (24): 21685–21692\. doi:10.1074/jbc.M301447200. PMID 12672821.
8. ^ Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (July 2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". The Journal of Biological Chemistry. 275 (29): 22503–22511\. doi:10.1074/jbc.M001698200. PMID 10801818.
9. ^ Hwang T, Parker SS, Hill SM, Ilunga MW, Grant RA, Mouneimne G, Keating AE (December 2021). "A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers". eLife. 10: e70601. doi:10.7554/eLife.70601. PMC 8639148. PMID 34854809.

## Further reading

[edit]

* Niebuhr K, Ebel F, Frank R, Reinhard M, Domann E, Carl UD, et al. (September 1997). "A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family". The EMBO Journal. 16 (17): 5433–5444\. doi:10.1093/emboj/16.17.5433. PMC 1170174. PMID 9312002.
* Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M (December 1997). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". The Journal of Biological Chemistry. 272 (52): 32869–32877\. doi:10.1074/jbc.272.52.32869. PMID 9407065.
* Mammoto A, Sasaki T, Asakura T, Hotta I, Imamura H, Takahashi K, et al. (February 1998). "Interactions of drebrin and gephyrin with profilin". Biochemical and Biophysical Research Communications. 243 (1): 86–89\. doi:10.1006/bbrc.1997.8068. PMID 9473484.
* Geese M, Schlüter K, Rothkegel M, Jockusch BM, Wehland J, Sechi AS (April 2000). "Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed". Journal of Cell Science. 113 ( Pt 8) (8): 1415–1426\. doi:10.1242/jcs.113.8.1415. PMID 10725224.
* Krause M, Sechi AS, Konradt M, Monner D, Gertler FB, Wehland J (April 2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton". The Journal of Cell Biology. 149 (1): 181–194\. doi:10.1083/jcb.149.1.181. PMC 2175102. PMID 10747096.
* Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (July 2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". The Journal of Biological Chemistry. 275 (29): 22503–22511\. doi:10.1074/jbc.M001698200. PMID 10801818.
* Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A (October 2001). "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex". Current Biology. 11 (21): 1645–1655\. Bibcode:2001CBio...11.1645K. doi:10.1016/S0960-9822(01)00506-1. PMID 11696321. S2CID 11290377.
* Coutts AS, MacKenzie E, Griffith E, Black DM (March 2003). "TES is a novel focal adhesion protein with a role in cell spreading". Journal of Cell Science. 116 (Pt 5): 897–906\. doi:10.1242/jcs.00278. PMID 12571287. S2CID 26602119.
* Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". The Journal of Biological Chemistry. 278 (24): 21685–21692\. doi:10.1074/jbc.M301447200. PMID 12672821.
* Garvalov BK, Higgins TE, Sutherland JD, Zettl M, Scaplehorn N, Köcher T, et al. (April 2003). "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions". The Journal of Cell Biology. 161 (1): 33–39\. doi:10.1083/jcb.200211015. PMC 2172870. PMID 12695497.
* Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, et al. (September 2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration". Developmental Biology. 261 (1): 251–267\. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
* Giesemann T, Schwarz G, Nawrotzki R, Berhörster K, Rothkegel M, Schlüter K, et al. (September 2003). "Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system". The Journal of Neuroscience. 23 (23): 8330–8339\. doi:10.1523/JNEUROSCI.23-23-08330.2003. PMC 6740687. PMID 12967995.
* Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman KL, et al. (December 2003). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". The Journal of Biological Chemistry. 278 (49): 49031–49043\. doi:10.1074/jbc.M308104200. PMID 14506234.
* Stüven T, Hartmann E, Görlich D (November 2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes". The EMBO Journal. 22 (21): 5928–5940\. doi:10.1093/emboj/cdg565. PMC 275422. PMID 14592989.
* Di Modugno F, Bronzi G, Scanlan MJ, Del Bello D, Cascioli S, Venturo I, et al. (May 2004). "Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response". International Journal of Cancer. 109 (6): 909–918\. doi:10.1002/ijc.20094. PMID 15027125.
* Tanoue T, Takeichi M (May 2004). "Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact". The Journal of Cell Biology. 165 (4): 517–528\. doi:10.1083/jcb.200403006. PMC 2172355. PMID 15148305.
* Krause M, Leslie JD, Stewart M, Lafuente EM, Valderrama F, Jagannathan R, et al. (October 2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics". Developmental Cell. 7 (4): 571–583\. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.

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* 1evh: EVH1 DOMAIN FROM MURINE ENABLED IN COMPLEX WITH ACTA PEPTIDE

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