Evolutionary Classification of Protein Domains

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ECODContent

Data types
captured| Protein domains
Contact
Research center| Grishin Lab, University of Texas Southwestern Medical Center
Authors| H. Cheng, R. D. Schaeffer, Y. Liao, L. N. Kinch, J. Pei, S. Shi, B. H. Kim, N. V. Grishin.
Primary citation| PMID 25474468
Release date| 2014
Access
Website| http://prodata.swmed.edu/ecod/
Miscellaneous
Version| continuously updated
Curation policy| manual for new proteins; automated for ones with close matches

The Evolutionary Classification of Protein Domains (ECOD) is a biological database that classifies protein domains available from the Protein Data Bank. The ECOD tries to determine the evolutionary relationships between proteins.

Similar to Pfam, CATH, and SCOP, ECOD compiles domains instead of whole proteins. However, ECOD focuses on evolutionary relationships more heavily: instead of grouping proteins by folds, which may simply represent convergent evolution, ECOD groups proteins by demonstratable homology only.[1]

## References

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1. ^ Cheng, H; Schaeffer, RD; Liao, Y; Kinch, LN; Pei, J; Shi, S; Kim, BH; Grishin, NV (December 2014). "ECOD: an evolutionary classification of protein domains". PLOS Computational Biology. 10 (12): e1003926. Bibcode:2014PLSCB..10E3926C. doi:10.1371/journal.pcbi.1003926. PMC 4256011. PMID 25474468.

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