Extracellular matrix protein 2

Protein-coding gene in the species Homo sapiens

ECM2

Identifiers
Aliases| ECM2, extracellular matrix protein 2
External IDs| OMIM: 603479; MGI: 3039578; HomoloGene: 1064; GeneCards: ECM2; OMA:ECM2 - orthologs
| Gene location (Human)

Chr.| Chromosome 9 (human)[1]

Band| 9q22.31| Start| 92,493,554 bp[1]
End| 92,536,655 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 13 (mouse)[2]

Band| 13|13 A5| Start| 49,658,286 bp[2]
End| 49,686,265 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* Achilles tendon

* synovial joint

* right coronary artery

* parietal pleura

* skin of hip

* tibia

* vena cava

* germinal epithelium

* Descending thoracic aorta

* ascending aorta

| Top expressed in

* esophagus

* aorta

* muscle of thigh

* ascending aorta

* lumbar spinal ganglion

* lip

* extraocular muscle

* aortic valve

* interventricular septum

* soleus muscle

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* collagen V binding
* integrin binding
* heparin binding
* collagen binding

Cellular component|

* extracellular region
* interstitial matrix
* extracellular space
* extracellular matrix

Biological process|

* cell-matrix adhesion
* extracellular matrix organization
* axonogenesis
* positive regulation of cell-substrate adhesion

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

1842

407800

Ensembl| |

ENSG00000106823

ENSMUSG00000043631

UniProt| |

O94769

Q5FW85

RefSeq (mRNA)| |

NM_001393
NM_001197295
NM_001197296

NM_001012324

RefSeq (protein)| |

NP_001184224
NP_001184225
NP_001384

NP_001012324

Location (UCSC)| Chr 9: 92.49 – 92.54 Mb| Chr 13: 49.66 – 49.69 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Extracellular matrix protein 2 is a protein that in humans is encoded by the ECM2 gene.[5][6]

ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known extracellular matrix proteins.[6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106823 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043631 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Nishiu J, Tanaka T, Nakamura Y (Dec 1998). "Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3". Genomics. 52 (3): 378–81\. doi:10.1006/geno.1998.5455. PMID 9790758.
6. ^ a b "Entrez Gene: ECM2 extracellular matrix protein 2, female organ and adipocyte specific".

## Further reading

[edit]

* Oritani K, Kanakura Y, Aoyama K, et al. (1997). "Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis". Blood. 90 (9): 3404–13\. doi:10.1182/blood.V90.9.3404. PMID 9345023.
* Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95\. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
* Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35\. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903\. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74\. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7\. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44\. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
* Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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