FEZ-like protein

Protein family

FEZ-like protein

Identifiers
Symbol| FEZ
Pfam| PF07763
InterPro| IPR011680
| Available protein structures:

Pfam | structures / ECOD
PDB| RCSB PDB; PDBe; PDBj
PDBsum| structure summary

In molecular biology, the FEZ-like protein family is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation.[1] The N-terminal regions of these sequences are less conserved than the C-terminal regions and are highly acidic.[1] The Caenorhabditis elegans homologue, UNC-76, may play structural and signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells[2]). These roles have also been postulated for other FEZ family proteins.[1] Certain homologues have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells.[2] The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta.[2] Members of this family are predicted to form coiled-coil structures,[2][3] which may interact with members of the RhoA family of signalling proteins,[2] but are not thought to contain other characteristic protein motifs.[3] Certain members of this family are expressed almost exclusively in the brain, whereas others (such as FEZ2) are expressed in other tissues, and are thought to perform similar, but unknown, functions in these tissues.[3]

## References

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1. ^ a b c Bloom L, Horvitz HR (April 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3414–9\. Bibcode:1997PNAS...94.3414B. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408.
2. ^ a b c d e Kuroda S, Nakagawa N, Tokunaga C, Tatematsu K, Tanizawa K (February 1999). "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein". J. Cell Biol. 144 (3): 403–11\. doi:10.1083/jcb.144.3.403. PMC 2132904. PMID 9971736.
3. ^ a b c Fujita T, Ikuta J, Hamada J, Okajima T, Tatematsu K, Tanizawa K, Kuroda S (January 2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3): 738–44\. doi:10.1016/j.bbrc.2003.12.006. PMID 14697253.

This article incorporates text from the public domain Pfam and InterPro: IPR011680