Firre

Non-coding RNA in the species Homo sapiens

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FIRRE

Identifiers
Aliases| FIRRE, LINC01200, functional intergenic repeating RNA element, firre intergenic repeating RNA element
External IDs| OMIM: 300999; MGI: 2147989; GeneCards: FIRRE; OMA:FIRRE - orthologs
| Gene location (Human)

Chr.| X chromosome (human)[1]

Band| Xq26.2| Start| 131,688,779 bp[1]
End| 131,830,862 bp[1]
| Gene location (Mouse)

Chr.| X chromosome (mouse)[2]

Band| X|X A5| Start| 49,644,621 bp[2]
End| 49,724,198 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

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| Top expressed in

* epithelium of colon

* sural nerve

* testicle

* body of pancreas

* gonad

* bone marrow cells

* C1 segment

* ventricular zone

* monocyte

* granulocyte

| Top expressed in

* neural layer of retina

* choroidal fissure

* fourth ventricle

* choroid plexus of fourth ventricle

* esophagus

* superior frontal gyrus

* cerebellar cortex

* otolith organ

* utricle

* epiblast

More reference expression data
BioGPS| | n/a

| Orthologs

Species| Human| Mouse
Entrez| |

286467

103012

Ensembl| |

ENSG00000213468

ENSMUSG00000085396

UniProt| |

n/a

RefSeq (mRNA)| |

n/a

n/a

RefSeq (protein)| |

n/a

n/a

Location (UCSC)| Chr X: 131.69 – 131.83 Mb| Chr X: 49.64 – 49.72 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

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Firre (functional intergenic repeating RNA element) is a long non-coding RNA located on chromosome X. It is retained in the nucleus via interaction with the nuclear matrix factor hnRNPU.[5] It mediates trans-chromosomal interactions[5] and anchors the inactive X chromosome to the nucleolus.[6] It plays a role in pluripotency[7] and adipogenesis.[8]

## See also

[edit]

* Long non-coding RNA

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213468 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000085396 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL (Feb 2014). "Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre". Nature Structural & Molecular Biology. 21 (2): 198–206\. doi:10.1038/nsmb.2764. PMC 3950333. PMID 24463464.
6. ^ Yang F, Deng X, Ma W, Berletch JB, Rabaia N, Wei G, Moore JM, Filippova GN, Xu J, Liu Y, Noble WS, Shendure J, Disteche CM (2015). "The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation". Genome Biology. 16 (52): 52. doi:10.1186/s13059-015-0618-0. PMC 4391730. PMID 25887447.
7. ^ Bergmann JH, Li J, Eckersley-Maslin MA, Rigo F, Freier SM, Spector DL (Sep 2015). "Regulation of the ESC transcriptome by nuclear long noncoding RNAs". Genome Research. 25 (9): 1336–1346\. doi:10.1101/gr.189027.114. PMC 4561492. PMID 26048247.
8. ^ Sun L, Goff LA, Trapnell C, Alexander R, Lo KA, Hacisuleyman E, Sauvageau M, Tazon-Vega B, Kelley DR, Hendrickson DG, Yuan B, Kellis M, Lodish HF, Rinn JL (Feb 2013). "Long noncoding RNAs regulate adipogenesis". Proceedings of the National Academy of Sciences of the United States of America. 110 (9): 3387–3392\. Bibcode:2013PNAS..110.3387S. doi:10.1073/pnas.1222643110. PMC 3587215. PMID 23401553.

## Further reading

[edit]

* Rinn J, Guttman M (Sep 2014). "RNA Function. RNA and dynamic nuclear organization". Science. 345 (6202): 1240–1241\. doi:10.1126/science.1252966. PMC 4186717. PMID 25214588.

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