formaldehyde dismutase

Identifiers
EC no.| 1.2.99.4
CAS no.| 85204-94-0
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
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PMC| articles
PubMed| articles
NCBI| proteins

In enzymology, a formaldehyde dismutase (EC 1.2.99.4) is an enzyme that catalyzes the chemical reaction

2 formaldehyde  ⇌ {\displaystyle \rightleftharpoons } formate + methanol

Hence, this enzyme has one substrate, formaldehyde, and two products, formate and methanol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with other acceptors. The systematic name of this enzyme class is formaldehyde:formaldehyde oxidoreductase. Other names in common use include aldehyde dismutase, and cannizzanase.

## Structural studies

[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2DPH.

## References

[edit]

* Kato N, Shirakawa K, Kobayashi H, Sakazawa C (1983). "The dismutation of aldehydes by a bacterial enzyme". Agric. Biol. Chem. 47: 39–46. doi:10.1271/bbb1961.47.39.

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Aldehyde/oxo oxidoreductases (EC 1.2)

1.2.1: NAD or NADP|

* Aldehyde dehydrogenase
* Acetaldehyde dehydrogenase
* Long-chain-aldehyde dehydrogenase
* Mycothiol-dependent formaldehyde dehydrogenase

1.2.2: cytochrome|

* Formate dehydrogenase (cytochrome)

1.2.3: oxygen|

* Aldehyde oxidase

1.2.4: disulfide|

* Oxoglutarate dehydrogenase complex
* Pyruvate dehydrogenase
* Branched-chain alpha-keto acid dehydrogenase complex
* BCKDHA
* BCKDHB
* DBT
* DLD

1.2.7: iron–sulfur protein|

* Pyruvate synthase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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