GAPDHS

Enzyme of the glycolysis metabolic pathway

GAPDHS

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

3H9E, 3PFW, 5C7O, 5C7L

Identifiers
Aliases| GAPDHS, GAPD2, GAPDH-2, GAPDS, HSD-35, HEL-S-278, glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
External IDs| OMIM: 609169; MGI: 95653; HomoloGene: 101265; GeneCards: GAPDHS; OMA:GAPDHS - orthologs
| Gene location (Human)

Chr.| Chromosome 19 (human)[1]

Band| 19q13.12| Start| 35,533,455 bp[1]
End| 35,545,319 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 7 (mouse)[2]

Band| 7|7 B1| Start| 30,429,200 bp[2]
End| 30,443,106 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* left testis

* right testis

* sperm

* testicle

* skin of leg

* skin of abdomen

* granulocyte

* right uterine tube

* tail of epididymis

* metanephros

| Top expressed in

* seminiferous tubule

* spermatid

* spermatocyte

* gastrula

* embryo

* tail of embryo

* neural layer of retina

* blastocyst

* tibiofemoral joint

* muscle of thigh

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* oxidoreductase activity
* NAD binding
* oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
* protein binding
* NADP binding
* glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity

Cellular component|

* cytoplasm
* cytosol
* nucleus

Biological process|

* flagellated sperm motility
* gluconeogenesis
* glycolytic process
* positive regulation of glycolytic process
* canonical glycolysis
* glucose metabolic process

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

26330

14447

Ensembl| |

ENSG00000105679

ENSMUSG00000061099

UniProt| |

O14556

Q64467

RefSeq (mRNA)| |

NM_014364

NM_001290631
NM_008085

RefSeq (protein)| |

NP_055179

NP_001277560
NP_032111

Location (UCSC)| Chr 19: 35.53 – 35.55 Mb| Chr 7: 30.43 – 30.44 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic or glyceraldehyde-3-phosphate dehydrogenase, testis-specific is an enzyme that in humans is encoded by the GAPDHS gene.[5][6]

## Function

[edit]

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.[6]

In melanocytic cells GAPDHS gene expression may be regulated by MITF.[7]

## Interactive pathway map

[edit]

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:

|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105679 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061099 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Welch JE, Brown PL, O'Brien DA, Magyar PL, Bunch DO, Mori C, Eddy EM (Apr 2000). "Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells". Journal of Andrology. 21 (2): 328–38. doi:10.1002/j.1939-4640.2000.tb02111.x. PMID 10714828. S2CID 28139434.
6. ^ a b "Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic".
7. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

## Further reading

[edit]

* Cooper TG, Yeung CH (Jun 1999). "Approaches to post-testicular contraception". Asian Journal of Andrology. 1 (1–2): 29–36. PMID 11225901.
* Benham FJ, Povey S (Aug 1989). "Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations". Genomics. 5 (2): 209–14. doi:10.1016/0888-7543(89)90048-7. PMID 2793178.
* Peterson RN, Freund M (Apr 1973). "Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa". Biology of Reproduction. 8 (3): 350–7. PMID 4349855. Archived from the original (PDF) on 2015-09-23. Retrieved 2011-10-14.
* Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
* Westhoff D, Kamp G (Aug 1997). "Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa". Journal of Cell Science. 110 (15): 1821–9. doi:10.1242/jcs.110.15.1821. PMID 9264469.
* Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
* Goodwin LO, Karabinus DS, Pergolizzi RG, Benoff S (Feb 2000). "L-type voltage-dependent calcium channel alpha-1C subunit mRNA is present in ejaculated human spermatozoa". Molecular Human Reproduction. 6 (2): 127–36. doi:10.1093/molehr/6.2.127. PMID 10655454.
* Bone W, Jones AR, Morin C, Nieschlag E, Cooper TG (2001). "Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro". Journal of Andrology. 22 (3): 464–70. doi:10.1002/j.1939-4640.2001.tb02203.x. PMID 11330647.
* Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
* Li Y, Nowotny P, Holmans P, Smemo S, Kauwe JS, Hinrichs AL, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Schrodi S, Leong D, Gogic G, Chan J, Cravchik A, Ross D, Lau K, Kwok S, Chang SY, Catanese J, Sninsky J, White TJ, Hardy J, Powell J, Lovestone S, Morris JC, Thal L, Owen M, Williams J, Goate A, Grupe A (Nov 2004). "Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15688–93. Bibcode:2004PNAS..10115688L. doi:10.1073/pnas.0403535101. PMC 524264. PMID 15507493.
* Kodama R, Kondo T, Yokote H, Jing X, Sawada T, Hironishi M, Sakaguchi K (Dec 2005). "Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+)". Genes to Cells. 10 (12): 1211–9. doi:10.1111/j.1365-2443.2005.00911.x. PMID 16324157. S2CID 22847496.
* Welch JE, Barbee RR, Magyar PL, Bunch DO, O'Brien DA (Aug 2006). "Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis". Molecular Reproduction and Development. 73 (8): 1052–60. doi:10.1002/mrd.20235. PMID 16700075. S2CID 6243286.
* Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM (Dec 2006). "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Human Molecular Genetics. 15 (23): 3411–9. doi:10.1093/hmg/ddl417. PMID 17047026.
* Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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