GET4

Protein-coding gene in the species Homo sapiens

GET4

Identifiers
Aliases| GET4, C7orf20, CEE, TRC35, CGI-20, golgi to ER traffic protein 4, guided entry of tail-anchored proteins factor 4
External IDs| OMIM: 612056; MGI: 1914854; HomoloGene: 41080; GeneCards: GET4; OMA:GET4 - orthologs
| Gene location (Human)

Chr.| Chromosome 7 (human)[1]

Band| 7p22.3| Start| 876,554 bp[1]
End| 896,436 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 5 (mouse)[2]

Band| 5|5 G2| Start| 139,238,079 bp[2]
End| 139,255,806 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* left testis

* right testis

* pituitary gland

* right adrenal cortex

* left adrenal cortex

* right uterine tube

* anterior pituitary

* right lobe of liver

* skin of leg

* skin of abdomen

| Top expressed in

* bone marrow

* yolk sac

* epiblast

* layer of retina

* neural layer of retina

* proximal tubule

* neural tube

* adrenal gland

* limb

* lip

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* protein binding
* chaperone binding

Cellular component|

* BAT3 complex
* cytosol
* cytoplasm
* nucleoplasm
* nucleolus

Biological process|

* cytoplasmic sequestering of protein
* tail-anchored membrane protein insertion into ER membrane
* maintenance of unfolded protein involved in ERAD pathway
* protein insertion into ER membrane

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

51608

67604

Ensembl| |

ENSG00000239857

ENSMUSG00000025858

UniProt| |

Q7L5D6

Q9D1H7

RefSeq (mRNA)| |

NM_015949

NM_001163316
NM_026269
NM_001359238

RefSeq (protein)| |

NP_057033

NP_001156788
NP_080545
NP_001346167

Location (UCSC)| Chr 7: 0.88 – 0.9 Mb| Chr 5: 139.24 – 139.26 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

GET4 is a protein that in humans is encoded by the GET4 gene.[5][6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000239857 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025858 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
6. ^ "Entrez Gene: C7orf20 chromosome 7 open reading frame 20".

## External links

[edit]

* Human GET4 genome location and GET4 gene details page in the UCSC Genome Browser.

## Further reading

[edit]

* Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
* Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
* Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

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