GRIN2A

Protein-coding gene in the species Homo sapiens

GRIN2A

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

3NFL, 5H8Q, 5H8H, 5H8N, 5H8F, 5I2N, 5I2K, 5KDT, 5KCJ

Identifiers
Aliases| GRIN2A, EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A, glutamate ionotropic receptor NMDA type subunit 2A
External IDs| OMIM: 138253; MGI: 95820; HomoloGene: 645; GeneCards: GRIN2A; OMA:GRIN2A - orthologs
| Gene location (Human)

Chr.| Chromosome 16 (human)[1]

Band| 16p13.2| Start| 9,753,404 bp[1]
End| 10,182,928 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 16 (mouse)[2]

Band| 16 A1|16 5.28 cM| Start| 9,385,762 bp[2]
End| 9,813,424 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* Brodmann area 23

* endothelial cell

* middle temporal gyrus

* postcentral gyrus

* lateral nuclear group of thalamus

* superior frontal gyrus

* primary visual cortex

* entorhinal cortex

* frontal pole

* Brodmann area 46

| Top expressed in

* Region I of hippocampus proper

* primary motor cortex

* subiculum

* prefrontal cortex

* lumbar subsegment of spinal cord

* olfactory tubercle

* hippocampus proper

* piriform cortex

* dentate gyrus

* Temporal Lobe

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* calcium channel activity
* zinc ion binding
* NMDA glutamate receptor activity
* metal ion binding
* ion channel activity
* protein binding
* ionotropic glutamate receptor activity
* cation channel activity
* extracellularly glutamate-gated ion channel activity
* amyloid-beta binding
* glutamate-gated calcium ion channel activity
* signaling receptor activity

Cellular component|

* integral component of membrane
* postsynaptic membrane
* membrane
* synaptic vesicle
* postsynaptic density
* plasma membrane
* synapse
* integral component of plasma membrane
* NMDA selective glutamate receptor complex
* cell surface
* cell junction
* endoplasmic reticulum
* neuron projection
* presynaptic membrane
* postsynaptic density membrane
* integral component of postsynaptic density membrane
* synaptic membrane
* glutamatergic synapse
* cell projection
* dendritic spine

Biological process|

* visual learning
* protein localization
* glutamate receptor signaling pathway
* neurogenesis
* startle response
* regulation of sensory perception of pain
* positive regulation of long-term synaptic potentiation
* negative regulation of protein catabolic process
* response to amphetamine
* regulation of membrane potential
* directional locomotion
* modulation of chemical synaptic transmission
* memory
* serotonin metabolic process
* ion transport
* learning
* cation transmembrane transport
* MAPK cascade
* regulation of synaptic plasticity
* sleep
* dopamine metabolic process
* ionotropic glutamate receptor signaling pathway
* response to wounding
* calcium ion transmembrane transport
* locomotion
* regulation of postsynaptic membrane potential
* excitatory postsynaptic potential
* learning or memory
* positive regulation of apoptotic process
* sensory perception of pain
* response to ethanol
* calcium ion transport
* long-term potentiation
* chemical synaptic transmission
* positive regulation of GTPase activity
* ion transmembrane transport
* regulation of ion transmembrane transport
* transport
* brain development
* calcium-mediated signaling
* activation of cysteine-type endopeptidase activity
* calcium ion transmembrane import into cytosol
* excitatory chemical synaptic transmission
* protein localization to postsynaptic membrane
* cellular response to amyloid-beta
* regulation of NMDA receptor activity

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

2903

14811

Ensembl| |

ENSG00000183454

ENSMUSG00000059003

UniProt| |

Q12879

P35436

RefSeq (mRNA)| |

NM_000833
NM_001134407
NM_001134408

NM_008170

RefSeq (protein)| |

NP_000824
NP_001127879
NP_001127880

NP_032196

Location (UCSC)| Chr 16: 9.75 – 10.18 Mb| Chr 16: 9.39 – 9.81 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Glutamate [NMDA] receptor subunit epsilon-1 is a protein that in humans is encoded by the GRIN2A gene.[5] With 1464 amino acids, the canonical GluN2A subunit isoform is large. GluN2A-short isoforms specific to primates can be produced by alternative splicing and contain 1281 amino acids.[6][7]

## Function

[edit]

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).[8]

## Associations

[edit]

Variants of the gene are associated with the protective effect of coffee on Parkinson's disease.[9][10]

Mutations in GRIN2A are associated to refractory epilepsy.[11]

Whole exome/genome sequencing has led to the discovery of an association between mutations in GRIN2A and a wide variety of neurological diseases, including epilepsy, intellectual disability, autism spectrum disorders, developmental delay, and schizophrenia.[12]

## Interactions

[edit]

GRIN2A has been shown to interact with:

* DLG1[13]
* DLG3[14][15]
* DLG4[14][15][16][17][18]
* FYN[16][19][20][21]
* Interleukin 16[22]
* PTK2B[23][24]
* Src[19][21]

## See also

[edit]

* Glutamate receptor
* NMDA receptor

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183454 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059003 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H (February 1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–425\. doi:10.1006/geno.1997.5132. PMID 9480759.423-425&rft.date=1998-02&rft_id=info:doi/10.1006/geno.1997.5132&rft_id=info:pmid/9480759&rft.aulast=Kalsi&rft.aufirst=G&rft.au=Whiting,+P&rft.au=Bourdelles,+BL&rft.au=Callen,+D&rft.au=Barnard,+EA&rft.au=Gurling,+H&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
6. ^ Warming H, Pegasiou CM, Pitera AP, Kariis H, Houghton SD, Kurbatskaya K, et al. (July 2019). "A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain". Molecular Brain. 12 (1): 64. doi:10.1186/s13041-019-0485-9. PMC 6610962. PMID 31272478.
7. ^ Herbrechter R, Hube N, Buchholz R, Reiner A (July 2021). "Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data". Cellular and Molecular Life Sciences. 78 (14): 5605–5630\. doi:10.1007/s00018-021-03865-z. PMC 8257547. PMID 34100982.5605-5630&rft.date=2021-07&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257547#id-name=PMC&rft_id=info:pmid/34100982&rft_id=info:doi/10.1007/s00018-021-03865-z&rft.aulast=Herbrechter&rft.aufirst=R&rft.au=Hube,+N&rft.au=Buchholz,+R&rft.au=Reiner,+A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257547&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
8. ^ "Entrez Gene: GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A".
9. ^ Hamza TH, Chen H, Hill-Burns EM, Rhodes SL, Montimurro J, Kay DM, et al. (August 2011). "Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee". PLOS Genetics. 7 (8): e1002237. doi:10.1371/journal.pgen.1002237. PMC 3158052. PMID 21876681.
10. ^ Yamada-Fowler N, Fredrikson M, Söderkvist P (June 2014). "Caffeine interaction with glutamate receptor gene GRIN2A: Parkinson's disease in Swedish population". PLOS ONE. 9 (6): e99294. Bibcode:2014PLoSO...999294Y. doi:10.1371/journal.pone.0099294. PMC 4051678. PMID 24915238.
11. ^ Venkateswaran S, Myers KA, Smith AC, Beaulieu CL, Schwartzentruber JA, Majewski J, et al. (July 2014). "Whole-exome sequencing in an individual with severe global developmental delay and intractable epilepsy identifies a novel, de novo GRIN2A mutation". Epilepsia. 55 (7): e75 – e79. doi:10.1111/epi.12663. PMID 24903190. S2CID 205116246.e75+-+e79&rft.date=2014-07&rft_id=https://api.semanticscholar.org/CorpusID:205116246#id-name=S2CID&rft_id=info:pmid/24903190&rft_id=info:doi/10.1111/epi.12663&rft.aulast=Venkateswaran&rft.aufirst=S&rft.au=Myers,+KA&rft.au=Smith,+AC&rft.au=Beaulieu,+CL&rft.au=Schwartzentruber,+JA&rft.au=Majewski,+J&rft.au=Bulman,+D&rft.au=Boycott,+KM&rft.au=Dyment,+DA&rft_id=https://doi.org/10.1111%2Fepi.12663&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
12. ^ Yuan H, Low CM, Moody OA, Jenkins A, Traynelis SF (July 2015). "Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases". Molecular Pharmacology. 88 (1): 203–217\. doi:10.1124/mol.115.097998. PMC 4468639. PMID 25904555.203-217&rft.date=2015-07&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468639#id-name=PMC&rft_id=info:pmid/25904555&rft_id=info:doi/10.1124/mol.115.097998&rft.aulast=Yuan&rft.aufirst=H&rft.au=Low,+CM&rft.au=Moody,+OA&rft.au=Jenkins,+A&rft.au=Traynelis,+SF&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468639&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
13. ^ Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M (November 2003). "CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction". The Journal of Biological Chemistry. 278 (45): 44745–44752\. doi:10.1074/jbc.M303576200. PMID 12933808.44745-44752&rft.date=2003-11&rft_id=info:doi/10.1074/jbc.M303576200&rft_id=info:pmid/12933808&rft.aulast=Gardoni&rft.aufirst=F&rft.au=Mauceri,+D&rft.au=Fiorentini,+C&rft.au=Bellone,+C&rft.au=Missale,+C&rft.au=Cattabeni,+F&rft.au=Di+Luca,+M&rft_id=https://doi.org/10.1074%2Fjbc.M303576200&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
14. ^ a b Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, et al. (September 1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–1515\. doi:10.1126/science.277.5331.1511. PMID 9278515.1511-1515&rft.date=1997-09&rft_id=info:doi/10.1126/science.277.5331.1511&rft_id=info:pmid/9278515&rft.aulast=Irie&rft.aufirst=M&rft.au=Hata,+Y&rft.au=Takeuchi,+M&rft.au=Ichtchenko,+K&rft.au=Toyoda,+A&rft.au=Hirao,+K&rft.au=Takai,+Y&rft.au=Rosahl,+TW&rft.au=Südhof,+TC&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
15. ^ a b Lim IA, Hall DD, Hell JW (June 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". The Journal of Biological Chemistry. 277 (24): 21697–21711\. doi:10.1074/jbc.M112339200. PMID 11937501.21697-21711&rft.date=2002-06&rft_id=info:doi/10.1074/jbc.M112339200&rft_id=info:pmid/11937501&rft.aulast=Lim&rft.aufirst=IA&rft.au=Hall,+DD&rft.au=Hell,+JW&rft_id=https://doi.org/10.1074%2Fjbc.M112339200&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
16. ^ a b Hou XY, Zhang GY, Yan JZ, Chen M, Liu Y (November 2002). "Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia". Brain Research. 955 (1–2): 123–132\. doi:10.1016/s0006-8993(02)03376-0. PMID 12419528. S2CID 85751.1–2&rft.pages=123-132&rft.date=2002-11&rft_id=https://api.semanticscholar.org/CorpusID:85751#id-name=S2CID&rft_id=info:pmid/12419528&rft_id=info:doi/10.1016/s0006-8993(02)03376-0&rft.aulast=Hou&rft.aufirst=XY&rft.au=Zhang,+GY&rft.au=Yan,+JZ&rft.au=Chen,+M&rft.au=Liu,+Y&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
17. ^ Satoh K, Yanai H, Senda T, Kohu K, Nakamura T, Okumura N, et al. (June 1997). "DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95". Genes to Cells. 2 (6): 415–424\. doi:10.1046/j.1365-2443.1997.1310329.x. PMID 9286858. S2CID 8934092.415-424&rft.date=1997-06&rft_id=https://api.semanticscholar.org/CorpusID:8934092#id-name=S2CID&rft_id=info:pmid/9286858&rft_id=info:doi/10.1046/j.1365-2443.1997.1310329.x&rft.aulast=Satoh&rft.aufirst=K&rft.au=Yanai,+H&rft.au=Senda,+T&rft.au=Kohu,+K&rft.au=Nakamura,+T&rft.au=Okumura,+N&rft.au=Matsumine,+A&rft.au=Kobayashi,+S&rft.au=Toyoshima,+K&rft.au=Akiyama,+T&rft_id=https://doi.org/10.1046%2Fj.1365-2443.1997.1310329.x&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
18. ^ Sans N, Petralia RS, Wang YX, Blahos J, Hell JW, Wenthold RJ (February 2000). "A developmental change in NMDA receptor-associated proteins at hippocampal synapses". The Journal of Neuroscience. 20 (3): 1260–1271\. doi:10.1523/JNEUROSCI.20-03-01260.2000. PMC 6774158. PMID 10648730.1260-1271&rft.date=2000-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774158#id-name=PMC&rft_id=info:pmid/10648730&rft_id=info:doi/10.1523/JNEUROSCI.20-03-01260.2000&rft.aulast=Sans&rft.aufirst=N&rft.au=Petralia,+RS&rft.au=Wang,+YX&rft.au=Blahos,+J&rft.au=Hell,+JW&rft.au=Wenthold,+RJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774158&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
19. ^ a b Ma J, Zhang GY (September 2003). "Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia". Neuroscience Letters. 348 (3): 185–189\. doi:10.1016/s0304-3940(03)00784-5. PMID 12932824. S2CID 40684016.185-189&rft.date=2003-09&rft_id=https://api.semanticscholar.org/CorpusID:40684016#id-name=S2CID&rft_id=info:pmid/12932824&rft_id=info:doi/10.1016/s0304-3940(03)00784-5&rft.aulast=Ma&rft.aufirst=J&rft.au=Zhang,+GY&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
20. ^ Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T (January 1999). "PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A". Proceedings of the National Academy of Sciences of the United States of America. 96 (2): 435–440\. Bibcode:1999PNAS...96..435T. doi:10.1073/pnas.96.2.435. PMC 15154. PMID 9892651.435-440&rft.date=1999-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC15154#id-name=PMC&rft_id=info:pmid/9892651&rft_id=info:doi/10.1073/pnas.96.2.435&rft_id=info:bibcode/1999PNAS...96..435T&rft.aulast=Tezuka&rft.aufirst=T&rft.au=Umemori,+H&rft.au=Akiyama,+T&rft.au=Nakanishi,+S&rft.au=Yamamoto,+T&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC15154&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
21. ^ a b Takagi N, Cheung HH, Bissoon N, Teves L, Wallace MC, Gurd JW (August 1999). "The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains". Journal of Cerebral Blood Flow and Metabolism. 19 (8): 880–888\. doi:10.1097/00004647-199908000-00007. PMID 10458595.880-888&rft.date=1999-08&rft_id=info:doi/10.1097/00004647-199908000-00007&rft_id=info:pmid/10458595&rft.aulast=Takagi&rft.aufirst=N&rft.au=Cheung,+HH&rft.au=Bissoon,+N&rft.au=Teves,+L&rft.au=Wallace,+MC&rft.au=Gurd,+JW&rft_id=https://doi.org/10.1097%2F00004647-199908000-00007&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
22. ^ Kurschner C, Yuzaki M (September 1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". The Journal of Neuroscience. 19 (18): 7770–7780\. doi:10.1523/JNEUROSCI.19-18-07770.1999. PMC 6782450. PMID 10479680.7770-7780&rft.date=1999-09&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782450#id-name=PMC&rft_id=info:pmid/10479680&rft_id=info:doi/10.1523/JNEUROSCI.19-18-07770.1999&rft.aulast=Kurschner&rft.aufirst=C&rft.au=Yuzaki,+M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782450&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
23. ^ Seabold GK, Burette A, Lim IA, Weinberg RJ, Hell JW (April 2003). "Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102". The Journal of Biological Chemistry. 278 (17): 15040–15048\. doi:10.1074/jbc.M212825200. PMID 12576483.15040-15048&rft.date=2003-04&rft_id=info:doi/10.1074/jbc.M212825200&rft_id=info:pmid/12576483&rft.aulast=Seabold&rft.aufirst=GK&rft.au=Burette,+A&rft.au=Lim,+IA&rft.au=Weinberg,+RJ&rft.au=Hell,+JW&rft_id=https://doi.org/10.1074%2Fjbc.M212825200&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
24. ^ Liu Y, Zhang G, Gao C, Hou X (August 2001). "NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion". Brain Research. 909 (1–2): 51–58\. doi:10.1016/s0006-8993(01)02619-1. PMID 11478920. S2CID 21062909.1–2&rft.pages=51-58&rft.date=2001-08&rft_id=https://api.semanticscholar.org/CorpusID:21062909#id-name=S2CID&rft_id=info:pmid/11478920&rft_id=info:doi/10.1016/s0006-8993(01)02619-1&rft.aulast=Liu&rft.aufirst=Y&rft.au=Zhang,+G&rft.au=Gao,+C&rft.au=Hou,+X&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">

## Further reading

[edit]

* Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–688\. PMID 9745929.4–5&rft.pages=683-688&rft.date=1998&rft_id=info:pmid/9745929&rft.aulast=Schröder&rft.aufirst=HC&rft.au=Perovic,+S&rft.au=Kavsan,+V&rft.au=Ushijima,+H&rft.au=Müller,+WE&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
* King JE, Eugenin EA, Buckner CM, Berman JW (April 2006). "HIV tat and neurotoxicity". Microbes and Infection. 8 (5): 1347–1357\. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.1347-1357&rft.date=2006-04&rft_id=info:doi/10.1016/j.micinf.2005.11.014&rft_id=info:pmid/16697675&rft.aulast=King&rft.aufirst=JE&rft.au=Eugenin,+EA&rft.au=Buckner,+CM&rft.au=Berman,+JW&rft_id=https://doi.org/10.1016%2Fj.micinf.2005.11.014&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
* Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, et al. (May 1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science. 256 (5060): 1217–1221\. Bibcode:1992Sci...256.1217M. doi:10.1126/science.256.5060.1217. PMID 1350383. S2CID 989677.1217-1221&rft.date=1992-05&rft_id=info:doi/10.1126/science.256.5060.1217&rft_id=https://api.semanticscholar.org/CorpusID:989677#id-name=S2CID&rft_id=info:pmid/1350383&rft_id=info:bibcode/1992Sci...256.1217M&rft.aulast=Monyer&rft.aufirst=H&rft.au=Sprengel,+R&rft.au=Schoepfer,+R&rft.au=Herb,+A&rft.au=Higuchi,+M&rft.au=Lomeli,+H&rft.au=Burnashev,+N&rft.au=Sakmann,+B&rft.au=Seeburg,+PH&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
* Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (September 1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–1740\. Bibcode:1995Sci...269.1737K. doi:10.1126/science.7569905. PMID 7569905.1737-1740&rft.date=1995-09&rft_id=info:pmid/7569905&rft_id=info:doi/10.1126/science.7569905&rft_id=info:bibcode/1995Sci...269.1737K&rft.aulast=Kornau&rft.aufirst=HC&rft.au=Schenker,+LT&rft.au=Kennedy,+MB&rft.au=Seeburg,+PH&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
* Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A (March 1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Annals of Neurology. 37 (3): 373–380\. doi:10.1002/ana.410370314. PMID 7695237. S2CID 24405132.373-380&rft.date=1995-03&rft_id=https://api.semanticscholar.org/CorpusID:24405132#id-name=S2CID&rft_id=info:pmid/7695237&rft_id=info:doi/10.1002/ana.410370314&rft.aulast=Magnuson&rft.aufirst=DS&rft.au=Knudsen,+BE&rft.au=Geiger,+JD&rft.au=Brownstone,+RM&rft.au=Nath,+A&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
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* Foldes RL, Adams SL, Fantaske RP, Kamboj RK (August 1994). "Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: cloning and sequencing of the cDNA and primary structure of the protein". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1223 (1): 155–159\. doi:10.1016/0167-4889(94)90086-8. PMID 8061049.155-159&rft.date=1994-08&rft_id=info:doi/10.1016/0167-4889(94)90086-8&rft_id=info:pmid/8061049&rft.aulast=Foldes&rft.aufirst=RL&rft.au=Adams,+SL&rft.au=Fantaske,+RP&rft.au=Kamboj,+RK&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
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* Roche KW, Raymond LA, Blackstone C, Huganir RL (April 1994). "Transmembrane topology of the glutamate receptor subunit GluR6". The Journal of Biological Chemistry. 269 (16): 11679–11682\. doi:10.1016/S0021-9258(17)32623-6. PMID 8163463.11679-11682&rft.date=1994-04&rft_id=info:doi/10.1016/S0021-9258(17)32623-6&rft_id=info:pmid/8163463&rft.aulast=Roche&rft.aufirst=KW&rft.au=Raymond,+LA&rft.au=Blackstone,+C&rft.au=Huganir,+RL&rft_id=https://doi.org/10.1016%2FS0021-9258%2817%2932623-6&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
* Takano H, Onodera O, Tanaka H, Mori H, Sakimura K, Hori T, et al. (December 1993). "Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel". Biochemical and Biophysical Research Communications. 197 (2): 922–926\. doi:10.1006/bbrc.1993.2567. PMID 8267632.922-926&rft.date=1993-12&rft_id=info:doi/10.1006/bbrc.1993.2567&rft_id=info:pmid/8267632&rft.aulast=Takano&rft.aufirst=H&rft.au=Onodera,+O&rft.au=Tanaka,+H&rft.au=Mori,+H&rft.au=Sakimura,+K&rft.au=Hori,+T&rft.au=Kobayashi,+H&rft.au=Mishina,+M&rft.au=Tsuji,+S&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
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* Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G (September 1995). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–321\. doi:10.1016/1055-8330(95)90021-7. PMID 8581564.315-321&rft.date=1995-09&rft_id=info:doi/10.1016/1055-8330(95)90021-7&rft_id=info:pmid/8581564&rft.aulast=Corasaniti&rft.aufirst=MT&rft.au=Melino,+G&rft.au=Navarra,+M&rft.au=Garaci,+E&rft.au=Finazzi-Agrò,+A&rft.au=Nisticò,+G&rfr_id=info:sid/en.wikipedia.org:GRIN2A" class="Z3988">
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* e

PDB gallery

* 2a5s: Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate

* 2a5t: Crystal Structure Of The NR1/NR2A ligand-binding cores complex

* v
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Ion channel, cell surface receptor: ligand-gated ion channels

Cys-loop receptors|

| 5-HT/serotonin|

* 5-HT3
* A
* B
* C
* D
* E

|

GABA|

* GABAA
* α1
* α2
* α3
* α4
* α5
* α6
* β1
* β2
* β3
* γ1
* γ2
* γ3
* δ
* ε
* π
* θ
* GABAA-ρ
* ρ1
* ρ2
* ρ3

Glycine|

* α1
* α2
* α3
* α4
* β

Nicotinic acetylcholine|

* monomers: α1
* α2
* α3
* α4
* α5
* α6
* α7
* α9
* α10
* β1
* β2
* β3
* β4
* δ
* ε

* pentamers: (α3)2(β4)3
* (α4)2(β2)3
* (α7)5
* (α1)2(β4)3 \- Ganglion type
* (α1)2β1δε - Muscle type

Zinc|

* Zinc-activated

Ionotropic glutamates|

| Ligand-gated only|

* AMPA (1
* 2
* 3
* 4)
* Kainate
* 1
* 2
* 3
* 4
* 5

|

Voltage- and ligand-gated|

* NMDA
* 1
* 2A
* 2B
* 2C
* 2D
* 3A
* 3B
* L1A
* L1B

‘Orphan’|

* GluD
* δ1
* δ2

ATP-gated channels|

| Purinergic receptors|

* P2X
* 1
* 2
* 3
* 4
* 5
* 6
* 7

|

This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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