GRIP1 (gene)

Protein-coding gene in the species Homo sapiens

Not to be confused with glucocorticoid receptor-interacting protein 1.

GRIP1

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

2JIL

Identifiers
Aliases| GRIP1, GRIP, glutamate receptor interacting protein 1, FRASRS3
External IDs| OMIM: 604597; MGI: 1921303; HomoloGene: 12938; GeneCards: GRIP1; OMA:GRIP1 - orthologs
| Gene location (Human)

Chr.| Chromosome 12 (human)[1]

Band| 12q14.3| Start| 66,347,431 bp[1]
End| 67,069,162 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 10 (mouse)[2]

Band| 10 D2|10 67.33 cM| Start| 119,289,735 bp[2]
End| 119,923,166 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* ganglionic eminence

* ventricular zone

* seminal vesicula

* secondary oocyte

* testicle

* skin of abdomen

* placenta

* buccal mucosa cell

* skin of leg

* right uterine tube

| Top expressed in

* Rostral migratory stream

* spermatid

* seminiferous tubule

* habenula

* secondary oocyte

* lumbar spinal ganglion

* olfactory bulb

* zygote

* barrel cortex

* motor neuron

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* beta-catenin binding
* transcription coactivator activity
* protein C-terminus binding
* protein binding
* androgen receptor binding
* glucocorticoid receptor binding
* signaling receptor complex adaptor activity

Cellular component|

* recycling endosome
* cytosol
* postsynaptic membrane
* membrane
* plasma membrane
* synapse
* cell junction
* dendrite
* endoplasmic reticulum
* membrane raft
* neuron projection
* cytoplasmic vesicle
* glutamatergic synapse

Biological process|

* protein localization
* androgen receptor signaling pathway
* intracellular signal transduction
* dendrite development
* positive regulation of transcription, DNA-templated
* neurotransmitter receptor transport, endosome to postsynaptic membrane
* vesicle-mediated transport in synapse
* positive regulation of neuron projection arborization
* positive regulation of signal transduction

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

23426

74053

Ensembl| |

ENSG00000155974

ENSMUSG00000034813

UniProt| |

Q9Y3R0

Q925T6

RefSeq (mRNA)| | NM_001178074
NM_021150
NM_001366722
NM_001366723
NM_001366724

NM_001379345
NM_001379346
NM_001379347
NM_001379348
NM_001379349
NM_001379351

| NM_001277292
NM_001277293
NM_001277294
NM_001277295
NM_028736

NM_130891
NM_133442
NM_001358809
NM_001358810
NM_001358811

RefSeq (protein)| | NP_001171545
NP_066973
NP_001353651
NP_001353652
NP_001353653

NP_001366274
NP_001366275
NP_001366276
NP_001366277
NP_001366278
NP_001366280

| NP_001264221
NP_001264222
NP_001264223
NP_001264224
NP_083012

NP_570961
NP_597699
NP_001345738
NP_001345739
NP_001345740

Location (UCSC)| Chr 12: 66.35 – 67.07 Mb| Chr 10: 119.29 – 119.92 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Glutamate receptor-interacting protein 1 is a protein that in humans is encoded by the GRIP1 gene.[5][6]

## Interactions

[edit]

GRIP1 (gene) has been shown to interact with:

* GRM3,[7]
* GRIA2,[7]
* GRIA3,[7]
* GRIA4,[7]
* GRIK2,[7][8] and
* GRIK3.[9]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155974 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034813 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R (April 1999). "EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains". Neuron. 22 (3): 511–24\. doi:10.1016/S0896-6273(00)80706-0. PMID 10197531.511-24&rft.date=1999-04&rft_id=info:doi/10.1016/S0896-6273(00)80706-0&rft_id=info:pmid/10197531&rft.aulast=Bruckner&rft.aufirst=K&rft.au=Pablo+Labrador,+J&rft.au=Scheiffele,+P&rft.au=Herb,+A&rft.au=Seeburg,+PH&rft.au=Klein,+R&rft_id=https://doi.org/10.1016%2FS0896-6273%2800%2980706-0&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
6. ^ "Entrez Gene: GRIP1 glutamate receptor interacting protein 1".
7. ^ a b c d e Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs" (PDF). J. Biol. Chem. 277 (18): 15221–4\. doi:10.1074/jbc.C200112200. PMID 11891216.15221-4&rft.date=2002-05&rft_id=info:doi/10.1074/jbc.C200112200&rft_id=info:pmid/11891216&rft.aulast=Hirbec&rft.aufirst=H&rft.au=Perestenko,+O&rft.au=Nishimune,+A&rft.au=Meyer,+G&rft.au=Nakanishi,+S&rft.au=Henley,+JM&rft.au=Dev,+KK&rft_id=https://hal.archives-ouvertes.fr/hal-02357764/file/PIIS0021925819356534.pdf&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
8. ^ Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron. 37 (4): 625–38\. doi:10.1016/S0896-6273(02)01191-1. PMC 3314502. PMID 12597860.625-38&rft.date=2003-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314502#id-name=PMC&rft_id=info:pmid/12597860&rft_id=info:doi/10.1016/S0896-6273(02)01191-1&rft.aulast=Hirbec&rft.aufirst=H&rft.au=Francis,+JC&rft.au=Lauri,+SE&rft.au=Braithwaite,+SP&rft.au=Coussen,+F&rft.au=Mulle,+C&rft.au=Dev,+KK&rft.au=Coutinho,+V&rft.au=Meyer,+G&rft.au=Isaac,+JT&rft.au=Collingridge,+GL&rft.au=Henley,+JM&rft.au=Couthino,+V&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314502&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
9. ^ Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (June 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17\. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157. S2CID 16571878.603-17&rft.date=2000-06&rft_id=https://api.semanticscholar.org/CorpusID:16571878#id-name=S2CID&rft_id=info:pmid/10896157&rft_id=info:doi/10.1016/S0896-6273(00)81198-8&rft.aulast=Ye&rft.aufirst=B&rft.au=Liao,+D&rft.au=Zhang,+X&rft.au=Zhang,+P&rft.au=Dong,+H&rft.au=Huganir,+RL&rft_id=https://doi.org/10.1016%2FS0896-6273%2800%2981198-8&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">

## Further reading

[edit]

* Irvine RA, Ma H, Yu MC, et al. (2000). "Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length". Hum. Mol. Genet. 9 (2): 267–74\. doi:10.1093/hmg/9.2.267. PMID 10607837.267-74&rft.date=2000&rft_id=info:doi/10.1093/hmg/9.2.267&rft_id=info:pmid/10607837&rft.aulast=Irvine&rft.aufirst=RA&rft.au=Ma,+H&rft.au=Yu,+MC&rft_id=https://doi.org/10.1093%2Fhmg%2F9.2.267&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Teyssier C, Belguise K, Galtier F, Chalbos D (2001). "Characterization of the physical interaction between estrogen receptor alpha and JUN proteins". J. Biol. Chem. 276 (39): 36361–9\. doi:10.1074/jbc.M101806200. PMID 11477071.36361-9&rft.date=2001&rft_id=info:doi/10.1074/jbc.M101806200&rft_id=info:pmid/11477071&rft.aulast=Teyssier&rft.aufirst=C&rft.au=Belguise,+K&rft.au=Galtier,+F&rft.au=Chalbos,+D&rft_id=https://doi.org/10.1074%2Fjbc.M101806200&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Lin SH, Arai AC, Wang Z, et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23\. doi:10.1124/mol.60.5.916. PMID 11641419. S2CID 9613515.916-23&rft.date=2001&rft_id=https://api.semanticscholar.org/CorpusID:9613515#id-name=S2CID&rft_id=info:pmid/11641419&rft_id=info:doi/10.1124/mol.60.5.916&rft.aulast=Lin&rft.aufirst=SH&rft.au=Arai,+AC&rft.au=Wang,+Z&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Hirbec H, Perestenko O, Nishimune A, et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4\. doi:10.1074/jbc.C200112200. hdl:2262/89271. PMID 11891216.15221-4&rft.date=2002&rft_id=info:hdl/2262/89271&rft_id=info:pmid/11891216&rft_id=info:doi/10.1074/jbc.C200112200&rft.aulast=Hirbec&rft.aufirst=H&rft.au=Perestenko,+O&rft.au=Nishimune,+A&rft_id=https://doi.org/10.1074%2Fjbc.C200112200&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Braithwaite SP, Xia H, Malenka RC (2002). "Differential roles for NSF and GRIP/ABP in AMPA receptor cycling". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7096–101\. Bibcode:2002PNAS...99.7096B. doi:10.1073/pnas.102156099. PMC 124534. PMID 12011465.7096-101&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124534#id-name=PMC&rft_id=info:pmid/12011465&rft_id=info:doi/10.1073/pnas.102156099&rft_id=info:bibcode/2002PNAS...99.7096B&rft.aulast=Braithwaite&rft.aufirst=SP&rft.au=Xia,+H&rft.au=Malenka,+RC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124534&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Kotaja N, Karvonen U, Jänne OA, Palvimo JJ (2002). "The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1". J. Biol. Chem. 277 (33): 30283–8\. doi:10.1074/jbc.M204768200. PMID 12060666.30283-8&rft.date=2002&rft_id=info:doi/10.1074/jbc.M204768200&rft_id=info:pmid/12060666&rft.aulast=Kotaja&rft.aufirst=N&rft.au=Karvonen,+U&rft.au=Jänne,+OA&rft.au=Palvimo,+JJ&rft_id=https://doi.org/10.1074%2Fjbc.M204768200&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Min G, Kim H, Bae Y, et al. (2002). "Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators". J. Biol. Chem. 277 (37): 34626–33\. doi:10.1074/jbc.M205239200. PMID 12114525.34626-33&rft.date=2002&rft_id=info:doi/10.1074/jbc.M205239200&rft_id=info:pmid/12114525&rft.aulast=Min&rft.aufirst=G&rft.au=Kim,+H&rft.au=Bae,+Y&rft_id=https://doi.org/10.1074%2Fjbc.M205239200&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell Sci. 116 (Pt 5): 897–906\. doi:10.1242/jcs.00278. PMID 12571287. S2CID 26602119.897-906&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:26602119#id-name=S2CID&rft_id=info:pmid/12571287&rft_id=info:doi/10.1242/jcs.00278&rft.aulast=Coutts&rft.aufirst=AS&rft.au=MacKenzie,+E&rft.au=Griffith,+E&rft.au=Black,+DM&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Charych EI, Yu W, Li R, et al. (2004). "A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brain". J. Biol. Chem. 279 (37): 38978–90\. doi:10.1074/jbc.M405786200. PMID 15226318.38978-90&rft.date=2004&rft_id=info:doi/10.1074/jbc.M405786200&rft_id=info:pmid/15226318&rft.aulast=Charych&rft.aufirst=EI&rft.au=Yu,+W&rft.au=Li,+R&rft_id=https://doi.org/10.1074%2Fjbc.M405786200&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Sugatani J, Nishitani S, Yamakawa K, et al. (2005). "Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1". Mol. Pharmacol. 67 (3): 845–55\. doi:10.1124/mol.104.007161. PMID 15557560. S2CID 5742622.845-55&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:5742622#id-name=S2CID&rft_id=info:pmid/15557560&rft_id=info:doi/10.1124/mol.104.007161&rft.aulast=Sugatani&rft.aufirst=J&rft.au=Nishitani,+S&rft.au=Yamakawa,+K&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Lin DY, Fang HI, Ma AH, et al. (2004). "Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx". Mol. Cell. Biol. 24 (24): 10529–41\. doi:10.1128/MCB.24.24.10529-10541.2004. PMC 533990. PMID 15572661.10529-41&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC533990#id-name=PMC&rft_id=info:pmid/15572661&rft_id=info:doi/10.1128/MCB.24.24.10529-10541.2004&rft.aulast=Lin&rft.aufirst=DY&rft.au=Fang,+HI&rft.au=Ma,+AH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC533990&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Yang CK, Kim JH, Li H, Stallcup MR (2006). "Differential use of functional domains by CoCoA in its synergistic coactivator function with β-catenin or GRIP1". J. Biol. Chem. 281 (6): 3389–97\. doi:10.1074/jbc.M510403200. PMC 1626527. PMID 16344550.3389-97&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626527#id-name=PMC&rft_id=info:pmid/16344550&rft_id=info:doi/10.1074/jbc.M510403200&rft.aulast=Yang&rft.aufirst=CK&rft.au=Kim,+JH&rft.au=Li,+H&rft.au=Stallcup,+MR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626527&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Liu PY, Hsieh TY, Chou WY, Huang SM (2006). "Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains". FEBS J. 273 (10): 2172–83\. doi:10.1111/j.1742-4658.2006.05231.x. PMID 16649994. S2CID 42365632.2172-83&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:42365632#id-name=S2CID&rft_id=info:pmid/16649994&rft_id=info:doi/10.1111/j.1742-4658.2006.05231.x&rft.aulast=Liu&rft.aufirst=PY&rft.au=Hsieh,+TY&rft.au=Chou,+WY&rft.au=Huang,+SM&rft_id=https://doi.org/10.1111%2Fj.1742-4658.2006.05231.x&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">
* Tsai SJ, Liou YJ, Liao DL, et al. (2007). "No association of GRIP1 gene polymorphisms with schizophrenia in Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 31 (3): 752–5\. doi:10.1016/j.pnpbp.2007.01.015. PMID 17303296. S2CID 25981856.752-5&rft.date=2007&rft_id=https://api.semanticscholar.org/CorpusID:25981856#id-name=S2CID&rft_id=info:pmid/17303296&rft_id=info:doi/10.1016/j.pnpbp.2007.01.015&rft.aulast=Tsai&rft.aufirst=SJ&rft.au=Liou,+YJ&rft.au=Liao,+DL&rfr_id=info:sid/en.wikipedia.org:GRIP1+(gene)" class="Z3988">

## External links

[edit]

* Overview of all the structural information available in the PDB for UniProt: Q9Y3R0 (Human Glutamate receptor-interacting protein) at the PDBe-KB.
* Overview of all the structural information available in the PDB for UniProt: Q925T6 (Mouse Glutamate receptor-interacting protein) at the PDBe-KB.

* v
* t
* e

PDB gallery

* 1m5z: The PDZ7 of Glutamate Receptor Interacting Protein Binds to its Target via a Novel Hydrophobic Surface Area

* 1n7e: Crystal structure of the sixth PDZ domain of GRIP1

* 1n7f: Crystal structure of the sixth PDZ domain of GRIP1 in complex with liprin C-terminal peptide

* 1p1d: Structural Insights into the Inter-domain Chaperoning of Tandem PDZ Domains in Glutamate Receptor Interacting Proteins

* 1v5q: Solution Structure of the PDZ Domain from Mouse Glutamate Receptor Interacting Protein 1A-L (GRIP1) Homolog

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