Galnon

Chemical compound

Pharmaceutical compound

Galnon

Identifiers

IUPAC name

* 9H-fluoren-9-ylmethyl N-[(2S)-1-([(2S)-6-amino-1-[(4-methyl-2-oxochromen-7- yl)amino]-1-oxohexan-2-yl]amino)-3-cyclohexyl-1-oxopropan-2-yl]carbamate

CAS Number|

* 475115-35-6 Y

PubChem CID|

* 5311268

IUPHAR/BPS|

* 6118

ChemSpider|

* 4470781 N

UNII|

* NK59Y4NQ33

ChEMBL|

* ChEMBL592414 N

CompTox Dashboard (EPA)|

* DTXSID301028771

Chemical and physical data
Formula| C40H46N4O6
Molar mass| 678.830 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* Cc3cc(=O)oc6cc(ccc36)NC(=O)C(CCCCN)NC(=O)C(CC5CCCCC5)NC(=O)OCC1c2ccccc2-c4c1cccc4

InChI

* InChI=1S/C40H46N4O6/c1-25-21-37(45)50-36-23-27(18-19-28(25)36)42-38(46)34(17-9-10-20-41)43-39(47)35(22-26-11-3-2-4-12-26)44-40(48)49-24-33-31-15-7-5-13-29(31)30-14-6-8-16-32(30)33/h5-8,13-16,18-19,21,23,26,33-35H,2-4,9-12,17,20,22,24,41H2,1H3,(H,42,46)(H,43,47)(H,44,48)/t34-,35-/m0/s1 N

* Key:IKNOZZKXIDSTRN-PXLJZGITSA-N N

NY (what is this?) (verify)

Galnon is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR.[1][2] It has anticonvulsant, anxiolytic, anorectic and amnestic effects in animal studies.[3][4][5][6][7]

## References

[edit]

1. ^ Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U (May 2002). "Anticonvulsant activity of a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America. 99 (10): 7136–41\. Bibcode:2002PNAS...99.7136S. doi:10.1073/pnas.102163499. PMC 124541. PMID 12011470.7136-41&rft.date=2002-05&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124541#id-name=PMC&rft_id=info:pmid/12011470&rft_id=info:doi/10.1073/pnas.102163499&rft_id=info:bibcode/2002PNAS...99.7136S&rft.aulast=Saar&rft.aufirst=K&rft.au=Mazarati,+AM&rft.au=Mahlapuu,+R&rft.au=Hallnemo,+G&rft.au=Soomets,+U&rft.au=Kilk,+K&rft.au=Hellberg,+S&rft.au=Pooga,+M&rft.au=Tolf,+BR&rft.au=Shi,+TS&rft.au=Hökfelt,+T&rft.au=Wasterlain,+C&rft.au=Bartfai,+T&rft.au=Langel,+U&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124541&rfr_id=info:sid/en.wikipedia.org:Galnon" class="Z3988">
2. ^ Sollenberg U, Bartfai T, Langel U (June 2005). "Galnon--a low-molecular weight ligand of the galanin receptors". Neuropeptides. 39 (3): 161–3\. doi:10.1016/j.npep.2004.12.019. PMID 15944006. S2CID 40987364.161-3&rft.date=2005-06&rft_id=https://api.semanticscholar.org/CorpusID:40987364#id-name=S2CID&rft_id=info:pmid/15944006&rft_id=info:doi/10.1016/j.npep.2004.12.019&rft.aulast=Sollenberg&rft.aufirst=U&rft.au=Bartfai,+T&rft.au=Langel,+U&rfr_id=info:sid/en.wikipedia.org:Galnon" class="Z3988">
3. ^ Abramov U, Florén A, Echevarria DJ, Brewer A, Manuzon H, Robinson JK, Bartfai T, Vasar E, Langel U (February 2004). "Regulation of feeding by galnon". Neuropeptides. 38 (1): 55–61\. doi:10.1016/j.npep.2004.01.001. PMID 15003717. S2CID 38073212.55-61&rft.date=2004-02&rft_id=https://api.semanticscholar.org/CorpusID:38073212#id-name=S2CID&rft_id=info:pmid/15003717&rft_id=info:doi/10.1016/j.npep.2004.01.001&rft.aulast=Abramov&rft.aufirst=U&rft.au=Florén,+A&rft.au=Echevarria,+DJ&rft.au=Brewer,+A&rft.au=Manuzon,+H&rft.au=Robinson,+JK&rft.au=Bartfai,+T&rft.au=Vasar,+E&rft.au=Langel,+U&rfr_id=info:sid/en.wikipedia.org:Galnon" class="Z3988">
4. ^ Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides. 39 (3): 249–51\. doi:10.1016/j.npep.2004.12.010. PMID 15944018. S2CID 2142254.249-51&rft.date=2005-06&rft_id=https://api.semanticscholar.org/CorpusID:2142254#id-name=S2CID&rft_id=info:pmid/15944018&rft_id=info:doi/10.1016/j.npep.2004.12.010&rft.aulast=Badie-Mahdavi&rft.aufirst=H&rft.au=Behrens,+MM&rft.au=Rebek,+J&rft.au=Bartfai,+T&rfr_id=info:sid/en.wikipedia.org:Galnon" class="Z3988">
5. ^ Rajarao SJ, Platt B, Sukoff SJ, Lin Q, Bender CN, Nieuwenhuijsen BW, Ring RH, Schechter LE, Rosenzweig-Lipson S, Beyer CE (October 2007). "Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon". Neuropeptides. 41 (5): 307–20\. doi:10.1016/j.npep.2007.05.001. PMID 17637475. S2CID 25988178.307-20&rft.date=2007-10&rft_id=https://api.semanticscholar.org/CorpusID:25988178#id-name=S2CID&rft_id=info:pmid/17637475&rft_id=info:doi/10.1016/j.npep.2007.05.001&rft.aulast=Rajarao&rft.aufirst=SJ&rft.au=Platt,+B&rft.au=Sukoff,+SJ&rft.au=Lin,+Q&rft.au=Bender,+CN&rft.au=Nieuwenhuijsen,+BW&rft.au=Ring,+RH&rft.au=Schechter,+LE&rft.au=Rosenzweig-Lipson,+S&rft.au=Beyer,+CE&rfr_id=info:sid/en.wikipedia.org:Galnon" class="Z3988">
6. ^ Kozlovsky N, Matar MA, Kaplan Z, Zohar J, Cohen H (March 2009). "The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder". Biological Psychiatry. 65 (5): 383–91\. doi:10.1016/j.biopsych.2008.10.034. PMID 19095221. S2CID 24537435.383-91&rft.date=2009-03&rft_id=https://api.semanticscholar.org/CorpusID:24537435#id-name=S2CID&rft_id=info:pmid/19095221&rft_id=info:doi/10.1016/j.biopsych.2008.10.034&rft.aulast=Kozlovsky&rft.aufirst=N&rft.au=Matar,+MA&rft.au=Kaplan,+Z&rft.au=Zohar,+J&rft.au=Cohen,+H&rfr_id=info:sid/en.wikipedia.org:Galnon" class="Z3988">
7. ^ Narasimhaiah R, Kamens HM, Picciotto MR (May 2009). "Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice". Psychopharmacology. 204 (1): 95–102\. doi:10.1007/s00213-008-1438-7. PMC 2872184. PMID 19099295.95-102&rft.date=2009-05&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872184#id-name=PMC&rft_id=info:pmid/19099295&rft_id=info:doi/10.1007/s00213-008-1438-7&rft.aulast=Narasimhaiah&rft.aufirst=R&rft.au=Kamens,+HM&rft.au=Picciotto,+MR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872184&rfr_id=info:sid/en.wikipedia.org:Galnon" class="Z3988">

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