Ghrelin

Peptide hormone involved in appetite regulation

GHRL

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

1P7X,%%s2JSH, 2JSI, 2JSJ

Identifiers
Aliases| GHRL, ghrelin, Ghrelin, ghrelin and obestatin prepropeptide, MTLRP
External IDs| OMIM: 605353; MGI: 1930008; HomoloGene: 9487; GeneCards: GHRL; OMA:GHRL - orthologs
| Gene location (Human)

Chr.| Chromosome 3 (human)[1]

Band| 3p25.3| Start| 10,285,666 bp[1]
End| 10,292,947 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 6 (mouse)[2]

Band| 6 E3|6 52.84 cM| Start| 113,693,080 bp[2]
End| 113,696,841 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* cardia

* body of stomach

* pancreatic epithelial cell

* fundus

* bone marrow cells

* pancreatic ductal cell

* islet of Langerhans

* duodenum

* testicle

* blood

| Top expressed in

* epithelium of stomach

* pyloric antrum

* mucous cell of stomach

* duodenum

* neural layer of retina

* spermatid

* embryo

* embryo

* spermatocyte

* migratory enteric neural crest cell

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* protein tyrosine kinase activator activity
* hormone activity
* protein binding
* ghrelin receptor binding
* G protein-coupled receptor binding
* growth hormone-releasing hormone activity

Cellular component|

* postsynapse
* cytoplasm
* endoplasmic reticulum lumen
* extracellular region
* axon
* secretory granule lumen
* extracellular space
* Schaffer collateral - CA1 synapse
* glutamatergic synapse

Biological process|

* positive regulation of appetite
* G protein-coupled receptor signaling pathway
* positive regulation of cortisol secretion
* positive regulation of growth hormone receptor signaling pathway
* negative regulation of insulin secretion
* gastric acid secretion
* positive regulation of cytosolic calcium ion concentration
* dendrite development
* regulation of response to food
* negative regulation of apoptotic process
* positive regulation of corticotropin secretion
* negative regulation of locomotion
* cortisol secretion
* response to estrogen
* negative regulation of endothelial cell proliferation
* positive regulation of circadian sleep/wake cycle, non-REM sleep
* cartilage development
* decidualization
* regulation of cell population proliferation
* growth hormone secretion
* positive regulation of growth hormone secretion
* excitatory postsynaptic potential
* hormone-mediated signaling pathway
* glucose metabolic process
* positive regulation of multicellular organism growth
* negative regulation of angiogenesis
* response to hormone
* actin polymerization or depolymerization
* positive regulation of response to food
* negative regulation of circadian sleep/wake cycle, REM sleep
* negative regulation of inflammatory response
* positive regulation of insulin secretion
* positive regulation of synapse assembly
* positive regulation of protein tyrosine kinase activity
* adult feeding behavior
* response to nutrient levels
* positive regulation of eating behavior
* positive regulation of adipose tissue development
* negative regulation of interleukin-1 beta production
* gastric emptying
* positive regulation of insulin secretion involved in cellular response to glucose stimulus
* positive regulation of growth
* response to electrical stimulus
* regulation of transmission of nerve impulse
* positive regulation of bone development
* positive regulation of sprouting angiogenesis
* positive regulation of gastro-intestinal system smooth muscle contraction
* positive regulation of small intestine smooth muscle contraction
* regulation of gastric motility
* positive regulation of vascular endothelial cell proliferation
* positive regulation of growth rate
* positive regulation of small intestinal transit
* positive regulation of gastric mucosal blood circulation
* positive regulation of feeding behavior
* regulation of signaling receptor activity
* energy homeostasis
* postsynaptic modulation of chemical synaptic transmission
* regulation of postsynapse organization
* positive regulation of cold-induced thermogenesis

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

51738

58991

Ensembl| |

ENSG00000157017

ENSMUSG00000064177

UniProt| |

Q9UBU3

Q9EQX0

RefSeq (mRNA)| | NM_001134941
NM_001134944
NM_001134945
NM_001134946
NM_001302821

NM_001302822
NM_001302823
NM_001302824
NM_001302825
NM_016362

NM_021488
NM_001286404
NM_001286405
NM_001286406
NM_001379129

RefSeq (protein)| | NP_001128413
NP_001128416
NP_001128417
NP_001128418
NP_001289750

NP_001289751
NP_001289752
NP_001289753
NP_001289754
NP_057446
NP_001128413
NP_001128416
NP_001128417
NP_001128418
NP_001289750
NP_001289751
NP_001289752
NP_001289753
NP_001289754
NP_057446

NP_001273333
NP_001273334
NP_001273335
NP_067463
NP_001366058

Location (UCSC)| Chr 3: 10.29 – 10.29 Mb| Chr 6: 113.69 – 113.7 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Ghrelin (/ˈɡrɛlɪn/; or lenomorelin, INN) is a hormone primarily produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach,[5][6] and is often called a "hunger hormone" because it increases the drive to eat.[6] Blood levels of ghrelin are highest before meals when hungry, returning to lower levels after mealtimes.[6][7] Ghrelin may help prepare for food intake[6][8] by increasing gastric motility and stimulating the secretion of gastric acid.[6]

Ghrelin activates cells in the anterior pituitary gland and hypothalamic arcuate nucleus,[6][9] including neuropeptide Y neurons that initiate appetite.[6][10] Ghrelin stimulates brain structures having a specific receptor - the growth hormone secretagogue receptor 1A (GHSR-1A).[6][11] Ghrelin also participates in regulation of reward cognition,[12] learning and memory, the sleep-wake cycle, taste sensation, reward behavior, and glucose metabolism.[6][13][14]

## History and name

[edit]

Ghrelin was discovered after the ghrelin receptor (called growth hormone secretagogue type 1A receptor or GHS-R) was determined in 1999.[6] The hormone name is based on its role as a growth hormone-releasing peptide, with reference to the Proto-Indo-European root gʰre-, meaning "to grow".[6]

## Gene, transcription products, and structure

[edit]

Preproghrelin (green and blue) and ghrelin (green)

The GHRL gene produces mRNA which has four exons. Five products arise: the first is the 117-amino acid preproghrelin. It is homologous to promotilin; both are members of the motilin family. It is cleaved to produce proghrelin which is cleaved to produce an unacylated 28-amino acid ghrelin and an acylated C-ghrelin. Obestatin is presumed to be cleaved from C-ghrelin.[15]

Ghrelin only becomes active when caprylic (octanoic) acid is linked posttranslationally to serine at the 3-position by the enzyme ghrelin O-acyltransferase (GOAT) to form a proteolipid. It is located on the cell membrane of ghrelin cells in the stomach and pancreas.[16] The non-octanoylated form is desacyl ghrelin. It does not activate the GHS-R receptor but does have other effects: cardiac,[17] anti-ghrelin,[18] appetite stimulation,[19] and inhibition of hepatic glucose output.[20] Side-chains other than octanoyl have also been observed: these can also trigger the ghrelin receptor.[21] In particular, decanoyl ghrelin has been found to constitute a significant portion of circulating ghrelin in mice, but as of 2011 its presence in humans has not been established.[22]

## Ghrelin cells

[edit]

### Alternative names

[edit]

The ghrelin cell is also known as an A-like cell (pancreas), X-cell (for unknown function), X/A-like cell (rats), Epsilon cell (pancreas), P/D sub 1 cell (humans) and Gr cell (abbreviation for ghrelin cell).[23]

### Location

[edit]

Ghrelin cells are found mainly in the stomach[24] and duodenum, but also in the jejunum, lungs, pancreatic islets,[25] gonads, adrenal cortex, placenta, and kidney. It has also been shown that ghrelin is produced locally in the brain.[26] Additionally, research suggests that ghrelin may be produced in the myocardium and have an 'autocrine/ paracrine' like effect within the heart.[27]

Ghrelin cells are also found in oxyntic glands (20% of cells),[28] pyloric glands, and small intestine.

### Features

[edit]

They are ovoid cells with granules.[29] They have gastrin receptors.[30] Some produce nesfatin-1.[31] Ghrelin cells are not terminally differentiated in the pancreas: they are progenitor cells that can give rise to A-cells, PP cells and Beta-cells there.[32]

## Function and mechanism of action

[edit]

Ghrelin is a participant in regulating the complex process of energy homeostasis which adjusts both energy input – by adjusting hunger signals – and energy output – by adjusting the proportion of energy going to ATP production, fat storage, glycogen storage, and short-term heat loss. The net result of these processes is reflected in body weight, and is under continuous monitoring and adjustment based on metabolic signals and needs. At any given moment in time, it may be in equilibrium or disequilibrium. Gastric-brain communication is an essential part of energy homeostasis, and several communication pathways are probable, including the gastric intracellular mTOR/S6K1 pathway mediating the interaction among ghrelin, nesfatin and endocannabinoid gastric systems,[33] and both afferent and efferent vagal signals.

Ghrelin and synthetic ghrelin mimetics (growth hormone secretagogues) increase body weight and fat mass[34][35][36] by triggering receptors in the arcuate nucleus[9] that include neuropeptide Y (NPY) and agouti-related protein (AgRP) neurons.[37][10] Ghrelin-responsiveness of these neurons is both leptin- and insulin-sensitive.[38] Ghrelin reduces the sensitivity of gastric vagal afferents, so they are less sensitive to gastric distension.[39]

In addition to its function in energy homeostasis, ghrelin also activates the cholinergic–dopaminergic reward link in inputs to the ventral tegmental area and in the mesolimbic pathway,[40] a circuit that communicates the hedonic and reinforcing aspects of natural rewards,[13] such as food and addictive drugs such as ethanol.[38][41][42] Ghrelin receptors are located on neurons in this circuit.[13][12] Hypothalamic ghrelin signalling is required for reward from alcohol[43] and palatable/rewarding foods.[44][45]

Ghrelin has been linked to inducing appetite and feeding behaviors. Circulating ghrelin levels are the highest right before a meal and the lowest right after.[46][47] Injections of ghrelin in both humans and rats have been shown to increase food intake in a dose-dependent manner.[48] So the more ghrelin that is injected the more food that is consumed. However, ghrelin does not increase meal size, only meal number.[49] Ghrelin injections also increase an animal's motivation to seek out food, behaviors including increased sniffing, foraging for food, and hoarding food. Body weight is regulated through energy balance, the amount of energy taken in versus the amount of energy expended over an extended period of time. Studies have shown that ghrelin levels are positively correlated with weight. This data suggests that ghrelin functions as an adiposity signal, a messenger between the body's energy stores and the brain.[8]

## Blood levels

[edit]

Blood levels are in the pmol/L or fmol/mL range. Both active and total ghrelin can be measured.[50] Circulating ghrelin concentrations rise before eating and fall afterward,[46] more strongly in response to protein and carbohydrate than to lipids.[22] The plasma ghrelin-like immunoreactivity concentration measured with a particular radioimmunoassay in a typical human is 166.0 + 10.1 fmol/mL. Serum ghrelin concentrations tend to increase in age and vary throughout the day, with values peaking while one is asleep.[51]

## Ghrelin receptor

[edit]

The ghrelin receptor GHS-R1a (a splice-variant of the growth hormone secretagogue receptor, with the GHS-R1b splice being inactive) is involved in mediating a wide variety of biological effects of ghrelin, including: stimulation of growth hormone release, increase in hunger, modulation of glucose and lipid metabolism, regulation of gastrointestinal motility and secretion, protection of neuronal and cardiovascular cells, and regulation of immune function.[52] They are present in high density in the hypothalamus and pituitary, on the vagus nerve (on both afferent cell bodies and efferent nerve endings) and throughout the gastrointestinal tract.[16][39]

## Locations of action

[edit]

### Glucose metabolism

[edit]

The entire ghrelin system (dAG, AG, GHS-R and GOAT) has a gluco-regulatory action.[53]

### Sleep

[edit]

Preliminary research indicates that ghrelin participates in the regulation of circadian rhythms.[6] A review reported finding strong evidence that sleep restriction affected ghrelin or leptin levels, or energy expenditure.[54]

### Reproductive system

[edit]

Ghrelin has inhibitory effects on gonadotropin-releasing hormone (GnRH) secretion. It may cause decreased fertility.[55]

### Fetus and neonate

[edit]

Ghrelin is produced early by the fetal lung and promotes lung growth.[56] Umbilical cord blood levels of ghrelin show a correlation between ghrelin levels and birth weight.[50]

### Cardiovascular system

[edit]

Ghrelin functions as a cardio-protective peptide by being an anti-inflammatory agent, promoting angiogenesis, inhibiting arrhythmia, and improving heart failure.[57]

### Immune system

[edit]

Ghrelin has a diverse immunoregulatory role mediating the release of anti-inflammatory cytokines such as IL-4 and 10 along with TGF-β while reducing pro-inflammatory cytokines such as TNF-α, INF-γ, and IL-1β from various immunologically competent cells in vitro and in vivo. [58] Additionally, Ghrelin and its endogenous receptor, GHSR1a, along with GOAT are expressed in primary immune tissues such as the spleen and thymus where it has a role in modulating interactions between metabolic state and inflammation, mediating energy balance homeostasis.[59]

### Stress/ Hypothalamic-pituitary-adrenal (HPA) axis

[edit]

GHSR1A, Ghrelin's endogenous receptor, is expressed within the hypothalamus including the arcuate nucleus, but not in the paraventricular nucleus (PVN) where ghrelin has been found to indirectly affect HPA axis function via neighboring corticotropin releasing hormone (CRH) neurons.[60] Studies regarding how ghrelin affects cortisol and adrenocorticotropic hormone (ACTH) secretion along with how cortisol and ACTH levels affect ghrelin are inconsistent as different psychological and physical stressors within in vivo studies have produced a myriad of results as the underlying mechanisms are still not understood well.[61]

## Role(s) in disease

[edit]

### Gastric bypass surgery

[edit]

Gastric bypass surgery not only reduces gut capacity for food, but also lowers ghrelin levels compared to both lean people and those who lost weight through dieting.[62][63] Studies have not clarified whether ghrelin levels return to normal in people who had gastric bypass surgery after weight loss has stabilized.[64] Gastric bypass surgery involving vertical-sleeve gastrectomy reduces plasma ghrelin levels by about 60% in the long term.[65]

### Anorexia and obesity

[edit]

Ghrelin levels in the plasma of obese individuals are lower than those in leaner individuals,[62][66] suggesting that ghrelin does not contribute to obesity, except in the cases of Prader–Willi syndrome-induced obesity, where high ghrelin levels are correlated with increased food intake.[67][68] Those with anorexia nervosa have high plasma levels of ghrelin[69] compared to both the constitutionally thin and normal-weight controls.[70][71] The level of ghrelin increases during the time of day from midnight to dawn in thinner people, which suggests there is a flaw in the circadian rhythm of obese individuals.[72] Ghrelin levels are high in people with cancer-induced cachexia.[73] There is insufficient evidence to conclude either for or against use of ghrelin in managing cachexia associated with cancer.[74]

### Effects on cardiovascular system

[edit]

Ghrelin has been theorized to have protective effects on the cardiovascular system. Studies have shown that in mice models of myocardial infarction (MI) with knock-outs of ghrelin, subjects with no endogenous ghrelin production had a significantly increased mortality rate along with worse metrics in terms of cardiac sympathetic activity and systolic function when compared to wild-type subjects.[57] with exogenous ghrelin being shown to improve heart function in rodent models of chronic heart failure [57] and improved ventricular remodeling in post-MI rats.[27]

## See also

[edit]

* Hypothalamic–pituitary–somatic axis
* List of growth hormone secretagogues
* Leptin
* Raptin

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157017 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064177 - Ensembl, May 2017
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4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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68. ^ DelParigi A, Tschöp M, Heiman ML, Salbe AD, Vozarova B, Sell SM, et al. (December 2002). "High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome". The Journal of Clinical Endocrinology and Metabolism. 87 (12): 5461–5464\. doi:10.1210/jc.2002-020871. PMID 12466337.5461-5464&rft.date=2002-12&rft_id=info:doi/10.1210/jc.2002-020871&rft_id=info:pmid/12466337&rft.aulast=DelParigi&rft.aufirst=A&rft.au=Tschöp,+M&rft.au=Heiman,+ML&rft.au=Salbe,+AD&rft.au=Vozarova,+B&rft.au=Sell,+SM&rft.au=Bunt,+JC&rft.au=Tataranni,+PA&rft_id=https://doi.org/10.1210%2Fjc.2002-020871&rfr_id=info:sid/en.wikipedia.org:Ghrelin" class="Z3988">
69. ^ Misra M, Klibanski A (July 2014). "Endocrine consequences of anorexia nervosa". The Lancet. Diabetes & Endocrinology. 2 (7): 581–592\. doi:10.1016/S2213-8587(13)70180-3. PMC 4133106. PMID 24731664.581-592&rft.date=2014-07&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133106#id-name=PMC&rft_id=info:pmid/24731664&rft_id=info:doi/10.1016/S2213-8587(13)70180-3&rft.aulast=Misra&rft.aufirst=M&rft.au=Klibanski,+A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133106&rfr_id=info:sid/en.wikipedia.org:Ghrelin" class="Z3988">
70. ^ Tolle V, Kadem M, Bluet-Pajot MT, Frere D, Foulon C, Bossu C, et al. (January 2003). "Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women". The Journal of Clinical Endocrinology and Metabolism. 88 (1): 109–116\. doi:10.1210/jc.2002-020645. PMID 12519838.109-116&rft.date=2003-01&rft_id=info:doi/10.1210/jc.2002-020645&rft_id=info:pmid/12519838&rft.aulast=Tolle&rft.aufirst=V&rft.au=Kadem,+M&rft.au=Bluet-Pajot,+MT&rft.au=Frere,+D&rft.au=Foulon,+C&rft.au=Bossu,+C&rft.au=Dardennes,+R&rft.au=Mounier,+C&rft.au=Zizzari,+P&rft.au=Lang,+F&rft.au=Epelbaum,+J&rft.au=Estour,+B&rft_id=https://doi.org/10.1210%2Fjc.2002-020645&rfr_id=info:sid/en.wikipedia.org:Ghrelin" class="Z3988">
71. ^ Germain N, Galusca B, Le Roux CW, Bossu C, Ghatei MA, Lang F, et al. (April 2007). "Constitutional thinness and lean anorexia nervosa display opposite concentrations of peptide YY, glucagon-like peptide 1, ghrelin, and leptin". The American Journal of Clinical Nutrition. 85 (4): 967–971\. doi:10.1093/ajcn/85.4.967. PMID 17413094.967-971&rft.date=2007-04&rft_id=info:doi/10.1093/ajcn/85.4.967&rft_id=info:pmid/17413094&rft.aulast=Germain&rft.aufirst=N&rft.au=Galusca,+B&rft.au=Le+Roux,+CW&rft.au=Bossu,+C&rft.au=Ghatei,+MA&rft.au=Lang,+F&rft.au=Bloom,+SR&rft.au=Estour,+B&rft_id=https://doi.org/10.1093%2Fajcn%2F85.4.967&rfr_id=info:sid/en.wikipedia.org:Ghrelin" class="Z3988">
72. ^ Yildiz BO, Suchard MA, Wong ML, McCann SM, Licinio J (July 2004). "Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity". Proceedings of the National Academy of Sciences of the United States of America. 101 (28): 10434–10439\. Bibcode:2004PNAS..10110434Y. doi:10.1073/pnas.0403465101. PMC 478601. PMID 15231997.10434-10439&rft.date=2004-07&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC478601#id-name=PMC&rft_id=info:pmid/15231997&rft_id=info:doi/10.1073/pnas.0403465101&rft_id=info:bibcode/2004PNAS..10110434Y&rft.aulast=Yildiz&rft.aufirst=BO&rft.au=Suchard,+MA&rft.au=Wong,+ML&rft.au=McCann,+SM&rft.au=Licinio,+J&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC478601&rfr_id=info:sid/en.wikipedia.org:Ghrelin" class="Z3988">
73. ^ Garcia JM, Garcia-Touza M, Hijazi RA, Taffet G, Epner D, Mann D, et al. (May 2005). "Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia". The Journal of Clinical Endocrinology and Metabolism. 90 (5): 2920–2926\. doi:10.1210/jc.2004-1788. PMID 15713718.2920-2926&rft.date=2005-05&rft_id=info:doi/10.1210/jc.2004-1788&rft_id=info:pmid/15713718&rft.aulast=Garcia&rft.aufirst=JM&rft.au=Garcia-Touza,+M&rft.au=Hijazi,+RA&rft.au=Taffet,+G&rft.au=Epner,+D&rft.au=Mann,+D&rft.au=Smith,+RG&rft.au=Cunningham,+GR&rft.au=Marcelli,+M&rft_id=https://doi.org/10.1210%2Fjc.2004-1788&rfr_id=info:sid/en.wikipedia.org:Ghrelin" class="Z3988">
74. ^ Khatib MN, Shankar AH, Kirubakaran R, Gaidhane A, Gaidhane S, Simkhada P, Quazi Syed Z (February 2018). "Ghrelin for the management of cachexia associated with cancer". The Cochrane Database of Systematic Reviews. 2 (2): CD012229. doi:10.1002/14651858.cd012229.pub2. PMC 6491219. PMID 29489032.

## External links

[edit]

Look up ghrelin in Wiktionary, the free dictionary.

* Overview of all the structural information available in the PDB for UniProt: Q9UBU3 (Human Appetite-regulating hormone) at the PDBe-KB.
* Overview of all the structural information available in the PDB for UniProt: Q9EQX0 (Mouse Appetite-regulating hormone) at the PDBe-KB.

* v
* t
* e

Hormones

Endocrine
glands|

| Hypothalamic–
pituitary|

| Hypothalamus|

* GnRH
* TRH
* Dopamine
* CRH
* GHRH
* Somatostatin (GHIH)
* MCH

|

Posterior pituitary|

* Oxytocin
* Vasopressin

Anterior pituitary|

* FSH
* LH
* TSH
* Prolactin
* POMC
* CLIP
* ACTH
* MSH
* Endorphins
* Lipotropin
* GH

Adrenal axis|

* Adrenal cortex
* Aldosterone
* Cortisol
* Cortisone
* DHEA
* DHEA-S
* Androstenedione
* Adrenal medulla
* Adrenaline
* Norepinephrine

Thyroid|

* Thyroid hormones
* T3
* T4
* Calcitonin
* Thyroid axis

Parathyroid|

* PTH

Gonadal axis|

| Testis|

* Testosterone
* AMH
* Inhibin

|

Ovary|

* Estradiol
* Progesterone
* Activin
* Inhibin
* Relaxin
* GnSAF

Placenta|

* hCG
* HPL
* Estrogen
* Progesterone

Pancreas|

* Glucagon
* Insulin
* Amylin
* Somatostatin
* Pancreatic polypeptide

Pineal gland|

* Melatonin
* N,N-Dimethyltryptamine
* 5-Methoxy-N,N-dimethyltryptamine

Other|

| Thymus|

* Thymosins
* Thymosin α1
* Beta thymosins
* Thymopoietin
* Thymulin

|

Digestive system|

| Stomach|

* Gastrin
* Ghrelin

|

Duodenum|

* CCK
* GIP
* Secretin
* Motilin
* VIP

Ileum|

* Enteroglucagon
* Peptide YY
* GLP-1

Liver/other|

* Insulin-like growth factor
* IGF-1
* IGF-2

Adipose tissue|

* Leptin
* Adiponectin
* Resistin

Skeleton|

* Osteocalcin

Kidney|

* Renin
* EPO
* Calcitriol
* Prostaglandin

Heart|

* Natriuretic peptide
* ANP
* BNP

* v
* t
* e

Peptides: neuropeptides

Hormones|

see hormones

Opioid peptides|

| Dynorphins|

* Dynorphin A
* Dynorphin A1–8
* Dynorphin B
* Big dynorphin
* Leumorphin
* α-Neoendorphin
* β-Neoendorphin

|

Endomorphins|

* Endomorphin-1
* Endomorphin-2

Endorphins|

* α-Endorphin
* β-Endorphin
* γ-Endorphin

Enkephalins|

* Met-enkephalin
* Leu-enkephalin

Others|

* Adrenorphin
* Amidorphin
* Hemorphin
* Hemorphin-4
* Nociceptin
* Opiorphin
* Spinorphin
* Valorphin

Other
neuropeptides|

| Kinins|

Bradykinins
Tachykinins: mammal

* Substance P
* Neurokinin A
* Neurokinin B

amphibian

* Kassinin
* Physalaemin

|

Neuromedins|

* B
* N
* S
* U

Orexins|

* A
* B

Other|

* Angiotensin
* Bombesin
* Calcitonin gene-related peptide
* Carnosine
* Cocaine- and amphetamine-regulated transcript
* Delta-sleep-inducing peptide
* FMRFamide
* Galanin
* Galanin-like peptide
* Gastrin-releasing peptide
* Ghrelin
* Neuropeptide AF
* Neuropeptide FF
* Neuropeptide SF
* Neuropeptide VF
* Neuropeptide S
* Neuropeptide Y
* Neurophysins
* Neurotensin
* Pancreatic polypeptide
* Pituitary adenylate cyclase-activating peptide
* RVD-Hpα
* VGF

* v
* t
* e

Appetite stimulants (A15)

Exogenous|

* Amitriptyline
* Clonidine
* Cyproheptadine
* Dexamethasone
* Dronabinol/Tetrahydrocannabinol (Cannabis)
* Medroxyprogesterone acetate
* Megestrol acetate
* Mirtazapine
* Nabilone
* Nandrolone
* Olanzapine
* Omega-3 fatty acid
* Oxandrolone
* Pentoxifylline
* Prednisone
* Sugars
* Testosterone
* Thalidomide

Endogenous|

* ACTH/Corticotropin
* Adiponectin
* Agouti-related peptide
* Anandamide
* Cortisol/Hydrocortisone
* Cortisone
* Ghrelin
* Melanin-concentrating hormone
* Melatonin
* Neuropeptide Y
* Orexin/Hypocretin

* v
* t
* e

GH/IGF-1 axis signaling modulators

(somatotropin)|

* Agonists: Albusomatropin
* Bovine somatotropin
* Efpegsomatropin
* Eftansomatropin alfa
* Growth hormone
* Human placental lactogen
* Lonapegsomatropin
* Placental growth hormone (growth hormone variant)
* Somagrebove
* Somapacitan
* Somatosalm
* Somatotropin
* Somatropin pegol
* Somatrem
* Sometribove
* Somatrogon (MOD-4023; hGH-CTP)
* Somavaratan
* Somavubove
* Somidobove

* Antagonists: G120K-hGH
* Pegvisomant

* Antisense oligonucleotides: Atesidorsen

* Binding proteins: GHBPTooltip Growth hormone-binding protein

GHIH
(somatostatin)|

* Agonists: BIM-23052
* CH-275
* Cortistatin-14
* Depreotide
* Edotreotide
* Ilatreotide
* L-803,087
* L-817,818
* Lanreotide
* NNC 26-9100
* Octreotate
* Octreotide
* Pasireotide
* Pentetreotide
* RC-160
* Seglitide
* Somatostatin (GHIH)
* Somatostatin (1-28)
* SRIF-14
* SRIF-28
* TT-232
* Vapreotide
* Veldoreotide

* Antagonists: BIM-23056
* Cyclosomatostatin
* CYN-154806
* Satoreotide

GHRH
(somatocrinin)|

* Agonists: Peptide: ALRN-5281
* CJC-1295
* Dumorelin
* GHRH
* Modified GRF (1-29)
* Rismorelin
* Sermorelin
* Somatorelin
* Tesamorelin

* Antagonists: MZ-5-156

GHS
(ghrelin)|

* Agonists: Peptide: Alexamorelin
* Cortistatin-14
* EP-51216
* Examorelin (hexarelin)
* Ghrelin
* GHRP-1
* GHRP-3
* GHRP-4
* GHRP-5
* GHRP-6
* Ipamorelin
* Lenomorelin
* Livoletide
* LY-444711
* Pralmorelin (GHRP-2)
* Relamorelin
* Tabimorelin
* Ulimorelin; Non-peptide: Adenosine
* Anamorelin
* Capromorelin
* CP-464709
* Ibutamoren (MK-677)
* L-692,585
* Macimorelin
* SM-130686; Unsorted: LY-426410
* LY-444711

* Antagonists: A-778193
* Cortistatin-8
* (D-Lys³)-GHRP-6
* JMV2959
* YIL-781

IGF-1
(somatomedin)|

* See here instead.

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template
*[GH]: Growth hormone
*[IGF-1]: Insulin-like growth factor 1
*[GHBP]: Growth hormone-binding protein
*[GHIH]: Growth hormone-inhibiting hormone
*[GHRH]: Growth hormone releasing hormone
*[GHS]: Growth hormone secretagogue