glucuronate isomerase

Identifiers
EC no.| 5.3.1.12
CAS no.| 9023-87-4
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
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PMC| articles
PubMed| articles
NCBI| proteins

In enzymology, a glucuronate isomerase (EC 5.3.1.12) is an enzyme that catalyzes the chemical reaction

D-glucuronate  ⇌ {\displaystyle \rightleftharpoons } D-fructuronate

Hence, this enzyme has one substrate, D-glucuronate, and one product, D-fructuronate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is D-glucuronate aldose-ketose-isomerase. Other names in common use include uronic isomerase, uronate isomerase, D-glucuronate isomerase, uronic acid isomerase, and D-glucuronate ketol-isomerase. This enzyme participates in pentose and glucuronate interconversions.

## Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1J5S and 2Q01.

## References[edit]

* Ashwell G, Wahba AJ, Hickman J (1960). "Uronic acid metabolism in bacteria. I. Purification and properties of uronic acid isomerase in Escherichia coli". J. Biol. Chem. 235: 1559–1565. PMID 13794771.
* KILGORE WW, STARR MP (1959). "Catabolism of galacturonic and glucuronic acids by Erwinia carotovora". J. Biol. Chem. 234: 2227–35. PMID 14409051.

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Isomerases: intramolecular oxidoreductases (EC 5.3)

5.3.1: Aldoses/Ketoses|

* Triosephosphate isomerase
* Ribose-5-phosphate isomerase
* Mannose phosphate isomerase
* Glucose isomerase

5.3.2: Keto/Enol|

* Phenylpyruvate tautomerase
* Oxaloacetate tautomerase
* 4-Oxalocrotonate tautomerase

5.3.3: C = C|

* Steroid D-isomerase
* Isopentenyl-diphosphate delta isomerase
* Vinylacetyl-CoA D-isomerase
* Muconolactone D-isomerase
* Cholestenol Delta-isomerase (EBP)
* Methylitaconate D-isomerase
* Aconitate Delta-isomerase
* Enoyl CoA isomerase
* Prostaglandin-A1 Delta-isomerase
* 5-carboxymethyl-2-hydroxymuconate D-isomerase
* Isopiperitenone D-isomerase
* L-dopachrome isomerase
* Polyenoic fatty acid isomerase

5.3.4: S-S|

* Protein disulfide-isomerase (PDIA3)

5.3.99: other|

* Prostaglandin D2 synthase/Prostaglandin-D synthase
* Prostaglandin E synthase
* Prostacyclin synthase
* Thromboxane-A synthase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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