Glycerol dehydratase

Class of enzymes

glycerol dehydratase

Identifiers
EC no.| 4.2.1.30
CAS no.| 9077-68-3
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
| Search

PMC| articles
PubMed| articles
NCBI| proteins
Representation of molecular structure of the protein registered with 1r8w code.

In enzymology, a glycerol dehydratase (EC 4.2.1.30) catalyzes the chemical reaction

glycerol  ⇌ {\displaystyle \rightleftharpoons } 3-hydroxypropanal + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is glycerol hydro-lyase (3-hydroxypropanol-forming). Other names in common use include glycerol dehydrase, and glycerol hydro-lyase. This enzyme participates in glycerolipid metabolism. It employs one cofactor, cobalamin.

## Structural studies

[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1IWP and 1MMF.

## References

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* Forage RG, Foster MA (1982). "Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases". J. Bacteriol. 149 (2): 413–9\. doi:10.1128/JB.149.2.413-419.1982. PMC 216523. PMID 7035429.
* Schneider Z, Larsen EG, Jacobson G, Johnson BC, Pawelkiewicz J (1970). "Purification and properties of glycerol dehydrase". J. Biol. Chem. 245 (13): 3388–96\. doi:10.1016/S0021-9258(18)63008-X. PMID 4989992.
* Schneider Z, Pawelkiewicz J (1966). "The properties of glycerol dehydratase isolated from Aerobacter aerogenes, and the properties of the apoenzyme subunits". Acta Biochim. Pol. 13 (4): 311–28\. PMID 5962440.
* SMILEY KL, SOBOLOV M (1962). "A cobamide-requiring glycerol dehydrase from an acrolein-forming Lactobacillus". Arch. Biochem. Biophys. 97 (3): 538–43\. doi:10.1016/0003-9861(62)90118-2. PMID 14039344.

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Carbon–oxygen lyases (EC 4.2) (primarily dehydratases)

4.2.1: Hydro-Lyases|

* Carbonic anhydrase
* Fumarase
* Aconitase
* Enolase
* Alpha
* Enolase 2
* Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase
* Methylglutaconyl-CoA hydratase
* Tryptophan synthase
* Cystathionine beta synthase
* Porphobilinogen synthase
* 3-Isopropylmalate dehydratase
* Urocanase
* Uroporphyrinogen III synthase
* Nitrile hydratase

4.2.2: Acting on polysaccharides|

* Hyaluronate lyase
* Pectin lyase

4.2.3: Acting on phosphates|

* Threonine synthase

4.2.99: Other|

* Carboxymethyloxysuccinate lyase
* Hydroperoxide lyase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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* Biology

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