Glycine oxidase

Class of enzymes

Glycine oxidase

Glycine oxidase tetramer, Geobacillus kaustophilus

Identifiers
EC no.| 1.4.3.19
CAS no.| 39307-16-9
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
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PMC| articles
PubMed| articles
NCBI| proteins

Glycine oxidase (EC 1.4.3.19) is an enzyme with systematic name glycine:oxygen oxidoreductase (deaminating).[1][2] This enzyme catalyses the following chemical reaction

glycine \+ H2O + O2 ⇌ {\displaystyle \rightleftharpoons } glyoxylate \+ NH3 \+ H2O2 (overall reaction)
(1a) glycine + O2 ⇌ {\displaystyle \rightleftharpoons } 2-iminoacetate + H2O2
(1b) 2-iminoacetate + H2O  ⇌ {\displaystyle \rightleftharpoons } glyoxylate + NH3

This flavoenzyme containing non-covalently bound FAD.

## References

[edit]

1. ^ Job V, Marcone GL, Pilone MS, Pollegioni L (March 2002). "Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein". The Journal of Biological Chemistry. 277 (9): 6985–93. doi:10.1074/jbc.M111095200. PMID 11744710.
2. ^ Nishiya Y, Imanaka T (November 1998). "Purification and characterization of a novel glycine oxidase from Bacillus subtilis". FEBS Letters. 438 (3): 263–6. doi:10.1016/s0014-5793(98)01313-1. PMID 9827558.

## External links

[edit]

* Glycine+oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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CH-NH2 oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases

1.4.1: NAD/NADP acceptor|

* Glutamate dehydrogenase
* GLUD1
* GLUD2
* Glutamate synthase (NADPH)

1.4.3: oxygen acceptor|

* D-amino acid oxidase
* Amine oxidase (Copper-containing (Lysyl
* Diamine
* Primary-amine)) (Flavin-containing (Monoamine)))

1.4.4: disulfide acceptor|

* Glycine cleavage system

1.4.99: other acceptors|

* D-amino acid dehydrogenase
* Amine dehydrogenase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

Portal:

* Biology

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