Glycoprotein Ib

Protein found in platelets

Glycoprotein Ib (GPIb), also known as CD42,[1] is a component of the GPIb-V-IX complex on platelets. The GPIb-V-IX complex binds von Willebrand factor, allowing platelet adhesion and platelet plug formation at sites of vascular injury. Glycoprotein Ibα (GPIbα) is the major ligand-binding subunit of the GPIb-V-IX complex. GPIbα is heavily glycosylated.[2]

It is deficient in the Bernard–Soulier syndrome. A gain-of-function mutation causes platelet-type von Willebrand disease.[3]

Autoantibodies against Ib/IX can be produced in immune thrombocytopenic purpura.[4]

Components include GP1BA and GP1BB.

It complexes with Glycoprotein IX.

## References

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1. ^ Bode AP, Read MS, Reddick RL (February 1999). "Activation and adherence of lyophilized human platelets on canine vessel strips in the Baumgartner perfusion chamber". The Journal of Laboratory and Clinical Medicine. 133 (2): 200–211\. doi:10.1016/S0022-2143(99)90013-6. PMID 9989772.
2. ^ Hollenhorst MA, Tiemeyer KH, Mahoney KE, Aoki K, Ishihara M, Lowery SC, et al. (April 2023). "Comprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation". Journal of Thrombosis and Haemostasis. 21 (4): 995–1009\. doi:10.1016/j.jtha.2023.01.009. PMC 10065957. PMID 36740532.
3. ^ McPherson RA, Pincus MR (2007). Henry's Clinical Diagnosis and Management by Laboratory Methods (21st ed.). Philadelphia, Pa: Saunders Elsevier. pp. 760–762\. ISBN 978-1-4160-0287-1.
4. ^ McMillan R (October 2007). "The pathogenesis of chronic immune thrombocytopenic purpura". Seminars in Hematology. 44 (4 Suppl 5): S3 – S11. doi:10.1053/j.seminhematol.2007.11.002. PMID 18096470.

## External links

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* Glycoprotein+Ib at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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Coagulation cascade

Coagulation factors|

| Primary hemostasis
(platelet activation)|

* von Willebrand factor (vWF)
* Platelet membrane glycoproteins: Glycoprotein Ib (GPIb) (GP1BA
* GP1BB
* Glycoprotein IX (GP9))
* Glycoprotein IIb/IIIa (GPIIb
* GPIIIa)
* Glycoprotein VI (GPVI)

|

Intrinsic pathway
(contact activation)|

* High-molecular-weight kininogen (HMWK)
* Bradykinin
* Prekallikrein
* Kallikrein
* Factor XII (Hageman factor)
* Factor XI
* Factor IX
* Factor VIII

Extrinsic pathway
(tissue factor)|

* Factor III (tissue factor)
* Factor VII

Common pathway|

* Factor X
* Factor V
* Prothrombin (factor II)
* Thrombin (factor IIa)
* Fibrinogen (factor I) (FGA, FGG)
* Fibrin (factor Ia)
* Factor XIII

Anticoagulant factors|

* Antithrombin (inhibits FII, FIX, FX, FXI, FXII)
* Protein C (inhibits FV, FVIII)
* Protein S (cofactor for protein C)
* Protein Z (inhibits FX)
* Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
* Tissue factor pathway inhibitor (TFPI) (inhibits FIII)

Fibrinolytic factors|

* Plasminogen
* Plasmin
* Tissue plasminogen activator (tPA)
* Urokinase
* Plasminogen activator inhibitor-1 (PAI-1)
* Plasminogen activator inhibitor-2 (PAI-2)
* α2-Antiplasmin
* α2-Macroglobulin
* Thrombin-activatable fibrinolysis inhibitor (TAFI)

Coagulation markers|

| Platelet activation|

* Platelet factor 4 (PF4)
* β-Thromboglobulin (β-TG)

|

Thrombin generation|

* Prothrombin fragment 1+2 (F1+2)
* Thrombin–antithrombin complex (TAT)
* Activated protein C–protein C inhibitor (APC–PCI)

Fibrin generation|

* Fibrinopeptide A (FpA)
* Fibrinopeptide B (FpB)
* Fibrin monomers (FM)

Fibrinolysis|

* Plasmin-α2-antiplasmin complex (PAP)
* D-Dimer (DD)

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* t
* e

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1–50|

* CD1
* a-c
* 1A
* 1B
* 1D
* 1E
* CD2
* CD3
* γ
* δ
* ε
* CD4
* CD5
* CD6
* CD7
* CD8
* a
* CD9
* CD10
* CD11
* a
* b
* c
* d
* CD13
* CD14
* CD15
* CD16
* A
* B
* CD18
* CD19
* CD20
* CD21
* CD22
* CD23
* CD24
* CD25
* CD26
* CD27
* CD28
* CD29
* CD30
* CD31
* CD32
* A
* B
* CD33
* CD34
* CD35
* CD36
* CD37
* CD38
* CD39
* CD40
* CD41
* CD42
* a
* b
* c
* d
* CD43
* CD44
* CD45
* CD46
* CD47
* CD48
* CD49
* a
* b
* c
* d
* e
* f
* CD50

51–100|

* CD51
* CD52
* CD53
* CD54
* CD55
* CD56
* CD57
* CD58
* CD59
* CD61
* CD62
* E
* L
* P
* CD63
* CD64
* A
* B
* C
* CD66
* a
* b
* c
* d
* e
* f
* CD68
* CD69
* CD70
* CD71
* CD72
* CD73
* CD74
* CD78
* CD79
* a
* b
* CD80
* CD81
* CD82
* CD83
* CD84
* CD85
* a
* d
* e
* h
* j
* k
* CD86
* CD87
* CD88
* CD89
* CD90
* CD91 \- CD92
* CD93
* CD94
* CD95
* CD96
* CD97
* CD98
* CD99
* CD100

101–150|

* CD101
* CD102
* CD103
* CD104
* CD105
* CD106
* CD107
* a
* b
* CD108
* CD109
* CD110
* CD111
* CD112
* CD113
* CD114
* CD115
* CD116
* CD117
* CD118
* CD119
* CD120
* a
* b
* CD121
* a
* b
* CD122
* CD123
* CD124
* CD125
* CD126
* CD127
* CD129
* CD130
* CD131
* CD132
* CD133
* CD134
* CD135
* CD136
* CD137
* CD138
* CD140b
* CD141
* CD142
* CD143
* CD144
* CD146
* CD147
* CD148
* CD150

151–200|

* CD151
* CD152
* CD153
* CD154
* CD155
* CD156
* a
* b
* c
* CD157
* CD158 (a
* d
* e
* i
* k)
* CD159
* a
* c
* CD160
* CD161
* CD162
* CD163
* CD164
* CD166
* CD167
* a
* b
* CD168
* CD169
* CD170
* CD171
* CD172
* a
* b
* g
* CD174
* CD177
* CD178
* CD179
* a
* b
* CD180
* CD181
* CD182
* CD183
* CD184
* CD185
* CD186
* CD191
* CD192
* CD193
* CD194
* CD195
* CD196
* CD197
* CDw198
* CDw199
* CD200

201–250|

* CD201
* CD202b
* CD204
* CD205
* CD206
* CD207
* CD208
* CD209
* CDw210
* a
* b
* CD212
* CD213a
* 1
* 2
* CD217
* CD218 (a
* b)
* CD220
* CD221
* CD222
* CD223
* CD224
* CD225
* CD226
* CD227
* CD228
* CD229
* CD230
* CD233
* CD234
* CD235
* a
* b
* CD236
* CD238
* CD239
* CD240CE
* CD240D
* CD241
* CD243
* CD244
* CD246
* CD247 \- CD248
* CD249

251–300|

* CD252
* CD253
* CD254
* CD256
* CD257
* CD258
* CD261
* CD262
* CD263
* CD264
* CD265
* CD266
* CD267
* CD268
* CD269
* CD271
* CD272
* CD273
* CD274
* CD275
* CD276
* CD278
* CD279
* CD280
* CD281
* CD282
* CD283
* CD284
* CD286
* CD288
* CD289
* CD290
* CD292
* CDw293
* CD294
* CD295
* CD297
* CD298
* CD299

301–350|

* CD300A
* CD301
* CD302
* CD303
* CD304
* CD305
* CD306
* CD307
* CD309
* CD312
* CD314
* CD315
* CD316
* CD317
* CD318
* CD320
* CD321
* CD322
* CD324
* CD325
* CD326
* CD327
* CD328
* CD329
* CD331
* CD332
* CD333
* CD334
* CD335
* CD336
* CD337
* CD338
* CD339
* CD340
* CD344
* CD349
* CD350

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