Gonadotropin-releasing hormone family

Family of peptides important in reproduction

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Gonadotropin-releasing hormone

Identifiers
Symbol| GnRH
Pfam| PF00446
InterPro| IPR002012
PROSITE| PDOC00432
| Available protein structures:

Pfam | structures / ECOD
PDB| RCSB PDB; PDBe; PDBj
PDBsum| structure summary

The gonadotropin-releasing hormones (GnRH) (gonadoliberin)[1] are a family of peptides that play a pivotal role in reproduction. The main function of GnRH is to act on the pituitary to stimulate the synthesis and secretion of luteinizing and follicle-stimulating hormones, but GnRH also acts on the brain, retina, sympathetic nervous system, gonads, and placenta in certain species. There seems to be at least three forms of GnRH. The second form is expressed in midbrain and seems to be widespread. The third form has been found so far only in fish. GnRH is a C-terminal amidated decapeptide processed from a larger precursor protein. Four of the ten residues are perfectly conserved in all species where GnRH has been sequenced.

## Subfamilies[edit]

* Gonadoliberin I InterPro: IPR004079

## Human proteins containing this domain[edit]

GNRH1, GNRH2

## References[edit]

1. ^ Sherwood N (1987). "The GnRH family of peptides". Trends Neurosci. 10 (3): 129–132. doi:10.1016/0166-2236(87)90058-0. S2CID 53188553.

This article incorporates text from the public domain Pfam and InterPro: IPR002012