HACL1 (gene)

Protein-coding gene in the species Homo sapiens

HACL1

Identifiers
Aliases| HACL1, 2-HPCL, HPCL, HPCL2, PHYH2, 2-hydroxyacyl-CoA lyase 1
External IDs| OMIM: 604300; MGI: 1929657; HomoloGene: 5794; GeneCards: HACL1; OMA:HACL1 - orthologs
| Gene location (Human)

Chr.| Chromosome 3 (human)[1]

Band| 3p25.1| Start| 15,560,699 bp[1]
End| 15,601,852 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 14 (mouse)[2]

Band| 14|14 B| Start| 31,320,687 bp[2]
End| 31,363,243 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* jejunal mucosa

* duodenum

* right lobe of liver

* secondary oocyte

* gonad

* skin of arm

* mucosa of ileum

* testicle

* right testis

* skin of thigh

| Top expressed in

* liver

* lip

* renal cortex

* spermatocyte

* proximal tubule

* human kidney

* right kidney

* white adipose tissue

* vasculature of organ

* bone marrow

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* thiamine pyrophosphate binding
* signaling receptor binding
* protein binding
* catalytic activity
* magnesium ion binding
* metal ion binding
* lyase activity
* carbon-carbon lyase activity
* identical protein binding

Cellular component|

* peroxisome
* peroxisomal matrix
* cytosol

Biological process|

* fatty acid alpha-oxidation
* protein complex oligomerization
* fatty acid metabolic process
* protein targeting to peroxisome
* lipid metabolism

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

26061

56794

Ensembl| |

ENSG00000131373

ENSMUSG00000021884

UniProt| |

Q9UJ83

Q9QXE0

RefSeq (mRNA)| |

NM_001284413
NM_001284415
NM_001284416
NM_012260

NM_019975

RefSeq (protein)| |

NP_001271342
NP_001271344
NP_001271345
NP_036392

NP_064359

Location (UCSC)| Chr 3: 15.56 – 15.6 Mb| Chr 14: 31.32 – 31.36 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

2-hydroxyacyl-CoA lyase 1 is a protein that in humans is encoded by the HACL1 gene. [5]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131373 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021884 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: 2-hydroxyacyl-CoA lyase 1". Retrieved 2016-04-10.

## Further reading

[edit]

* Foulon V, Antonenkov VD, Croes K, Waelkens E, Mannaerts GP, Van Veldhoven PP, Casteels M (1999). "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. Bibcode:1999PNAS...9610039F. doi:10.1073/pnas.96.18.10039. PMC 17838. PMID 10468558.

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