HCST (gene)

Protein-coding gene in the species Homo sapiens

HCST

Identifiers
Aliases| HCST, DAP10, KAP10, PIK3AP, hematopoietic cell signal transducer
External IDs| OMIM: 604089; MGI: 1344360; HomoloGene: 8024; GeneCards: HCST; OMA:HCST - orthologs
| Gene location (Human)

Chr.| Chromosome 19 (human)[1]

Band| 19q13.12| Start| 35,902,529 bp[1]
End| 35,904,377 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 7 (mouse)[2]

Band| 7 B1|7 17.45 cM| Start| 30,117,137 bp[2]
End| 30,119,279 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* granulocyte

* monocyte

* bone marrow

* blood

* bone marrow cell

* spleen

* appendix

* lymph node

* thymus

* trabecular bone

| Top expressed in

* granulocyte

* thymus

* tibiofemoral joint

* blood

* spleen

* mesenteric lymph nodes

* embryo

* embryo

* duodenum

* right kidney

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* signaling receptor binding
* protein binding
* phosphatidylinositol 3-kinase binding

Cellular component|

* integral component of membrane
* cell surface
* plasma membrane
* membrane

Biological process|

* protein phosphorylation
* regulation of immune response
* positive regulation of phosphatidylinositol 3-kinase signaling

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

10870

23900

Ensembl| |

ENSG00000126264

ENSMUSG00000064109

UniProt| |

Q9UBK5

Q9QUJ0

RefSeq (mRNA)| |

NM_014266
NM_001007469

NM_011827

RefSeq (protein)| |

NP_001007470
NP_055081

NP_035957

Location (UCSC)| Chr 19: 35.9 – 35.9 Mb| Chr 7: 30.12 – 30.12 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Hematopoietic cell signal transducer is a protein that in humans is encoded by the HCST gene.[5][6]

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.[6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126264 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064109 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH (Aug 1999). "An activating immunoreceptor complex formed by NKG2D and DAP10". Science. 285 (5428): 730–2\. doi:10.1126/science.285.5428.730. PMID 10426994.
6. ^ a b "Entrez Gene: HCST hematopoietic cell signal transducer".

## Further reading

[edit]

* Karimi M, Cao TM, Baker JA, et al. (2006). "Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells". J. Immunol. 175 (12): 7819–28\. doi:10.4049/jimmunol.175.12.7819. PMID 16339517.
* André P, Castriconi R, Espéli M, et al. (2004). "Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors". Eur. J. Immunol. 34 (4): 961–71\. doi:10.1002/eji.200324705. PMID 15048706.
* Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70\. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
* Billadeau DD, Upshaw JL, Schoon RA, et al. (2003). "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway". Nat. Immunol. 4 (6): 557–64\. doi:10.1038/ni929. PMID 12740575. S2CID 7699074.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903\. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Diefenbach A, Tomasello E, Lucas M, et al. (2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D". Nat. Immunol. 3 (12): 1142–9\. doi:10.1038/ni858. PMID 12426565. S2CID 14901451.
* Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation". Nat. Immunol. 3 (12): 1150–5\. doi:10.1038/ni857. PMID 12426564. S2CID 5859797.
* Yim D, Jie HB, Sotiriadis J, et al. (2001). "Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D". Immunogenetics. 53 (3): 243–9\. doi:10.1007/s002510100321. PMID 11398969. S2CID 23708388.
* Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33\. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
* Wu J, Cherwinski H, Spies T, et al. (2000). "DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells". J. Exp. Med. 192 (7): 1059–68\. doi:10.1084/jem.192.7.1059. PMC 2193316. PMID 11015446.
* Chang C, Dietrich J, Harpur AG, et al. (1999). "Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties". J. Immunol. 163 (9): 4651–4\. doi:10.4049/jimmunol.163.9.4651. PMID 10528161.

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