HOOK3

Protein-coding gene in the species Homo sapiens

HOOK3

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

5J8E

Identifiers
Aliases| HOOK3, HK3, hook microtubule-tethering protein 3, hook microtubule tethering protein 3
External IDs| OMIM: 607825; MGI: 2443554; HomoloGene: 13022; GeneCards: HOOK3; OMA:HOOK3 - orthologs
| Gene location (Human)

Chr.| Chromosome 8 (human)[1]

Band| 8p11.21| Start| 42,896,946 bp[1]
End| 43,030,535 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 8 (mouse)[2]

Band| 8|8 A2| Start| 26,511,449 bp[2]
End| 26,609,252 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* Achilles tendon

* sural nerve

* tendon of biceps brachii

* epithelium of colon

* pancreatic epithelial cell

* corpus callosum

* endothelial cell

* buccal mucosa cell

* internal globus pallidus

* deltoid muscle

| Top expressed in

* otolith organ

* utricle

* knee joint

* tibialis anterior muscle

* hand

* triceps brachii muscle

* vastus lateralis muscle

* Rostral migratory stream

* tail of embryo

* foot

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* microtubule binding
* protein binding
* identical protein binding
* dynein light intermediate chain binding
* dynactin binding
* dynein light chain binding
* dynein intermediate chain binding

Cellular component|

* HOPS complex
* FHF complex
* cis-Golgi network
* centriolar satellite
* microtubule
* cytoskeleton
* cytosol
* pericentriolar material
* cytoplasm
* Golgi apparatus
* centrosome

Biological process|

* endosome to lysosome transport
* endosome organization
* neuronal stem cell population maintenance
* Golgi localization
* early endosome to late endosome transport
* cytoplasmic microtubule organization
* protein transport
* lysosome organization
* microtubule anchoring at centrosome
* interkinetic nuclear migration
* negative regulation of neurogenesis
* protein localization to centrosome
* cytoskeleton-dependent intracellular transport

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

84376

320191

Ensembl| |

ENSG00000168172

ENSMUSG00000037234

UniProt| |

Q86VS8

Q8BUK6

RefSeq (mRNA)| |

NM_032410

NM_207659

RefSeq (protein)| |

NP_115786

NP_997542

Location (UCSC)| Chr 8: 42.9 – 43.03 Mb| Chr 8: 26.51 – 26.61 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.[5][6]

## Function

[edit]

Hook proteins are cytosolic coiled coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168172 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037234 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Kramer H, Phistry M (Mar 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84\. doi:10.1093/genetics/151.2.675. PMC 1460498. PMID 9927460.675-84&rft.date=1999-03&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1460498#id-name=PMC&rft_id=info:pmid/9927460&rft_id=info:doi/10.1093/genetics/151.2.675&rft.aulast=Kramer&rft.aufirst=H&rft.au=Phistry,+M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1460498&rfr_id=info:sid/en.wikipedia.org:HOOK3" class="Z3988">
6. ^ a b "Entrez Gene: HOOK3 hook homolog 3 (Drosophila)".

## Further reading

[edit]

* Walenta JH, Didier AJ, Liu X, Krämer H (2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34\. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.923-34&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198811#id-name=PMC&rft_id=info:pmid/11238449&rft_id=info:doi/10.1083/jcb.152.5.923&rft.aulast=Walenta&rft.aufirst=JH&rft.au=Didier,+AJ&rft.au=Liu,+X&rft.au=Krämer,+H&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198811&rfr_id=info:sid/en.wikipedia.org:HOOK3" class="Z3988">
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903\. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold,+EA&rft.au=Grouse,+LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:HOOK3" class="Z3988">
* Shotland Y, Krämer H, Groisman EA (2003). "The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking". Mol. Microbiol. 49 (6): 1565–76\. doi:10.1046/j.1365-2958.2003.03668.x. PMID 12950921. S2CID 30972454.1565-76&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:30972454#id-name=S2CID&rft_id=info:pmid/12950921&rft_id=info:doi/10.1046/j.1365-2958.2003.03668.x&rft.aulast=Shotland&rft.aufirst=Y&rft.au=Krämer,+H&rft.au=Groisman,+EA&rft_id=https://doi.org/10.1046%2Fj.1365-2958.2003.03668.x&rfr_id=info:sid/en.wikipedia.org:HOOK3" class="Z3988">
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5\. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki,+Y&rft.au=Nishikawa,+T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:HOOK3" class="Z3988">
* Kaiser F, Kaufmann SH, Zerrahn J (2004). "IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3". J. Cell Sci. 117 (Pt 9): 1747–56\. doi:10.1242/jcs.01039. PMID 15075236. S2CID 294834.1747-56&rft.date=2004&rft_id=https://api.semanticscholar.org/CorpusID:294834#id-name=S2CID&rft_id=info:pmid/15075236&rft_id=info:doi/10.1242/jcs.01039&rft.aulast=Kaiser&rft.aufirst=F&rft.au=Kaufmann,+SH&rft.au=Zerrahn,+J&rfr_id=info:sid/en.wikipedia.org:HOOK3" class="Z3988">
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7\. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner,+L&rft.au=Feingold,+EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:HOOK3" class="Z3988">
* Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58\. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.442-58&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:25389776#id-name=S2CID&rft_id=info:pmid/15882442&rft_id=info:doi/10.1111/j.1600-0854.2005.00289.x&rft.aulast=Simpson&rft.aufirst=F&rft.au=Martin,+S&rft.au=Evans,+TM&rft_id=https://doi.org/10.1111%2Fj.1600-0854.2005.00289.x&rfr_id=info:sid/en.wikipedia.org:HOOK3" class="Z3988">
* Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92\. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.1285-92&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:14294292#id-name=S2CID&rft_id=info:pmid/16964243&rft_id=info:doi/10.1038/nbt1240&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Villén,+J&rft.au=Gerber,+SA&rfr_id=info:sid/en.wikipedia.org:HOOK3" class="Z3988">
* Sano H, Ishino M, Krämer H, et al. (2007). "The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A." J. Biol. Chem. 282 (11): 7973–81\. doi:10.1074/jbc.M611537200. PMID 17237231.7973-81&rft.date=2007&rft_id=info:doi/10.1074/jbc.M611537200&rft_id=info:pmid/17237231&rft.aulast=Sano&rft.aufirst=H&rft.au=Ishino,+M&rft.au=Krämer,+H&rft_id=https://doi.org/10.1074%2Fjbc.M611537200&rfr_id=info:sid/en.wikipedia.org:HOOK3" class="Z3988">
* Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, et al. (2007). "HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma". Endocr. Relat. Cancer. 14 (2): 445–52\. doi:10.1677/ERC-07-0039. PMID 17639057.445-52&rft.date=2007&rft_id=info:doi/10.1677/ERC-07-0039&rft_id=info:pmid/17639057&rft.aulast=Ciampi&rft.aufirst=R&rft.au=Giordano,+TJ&rft.au=Wikenheiser-Brokamp,+K&rft_id=https://doi.org/10.1677%2FERC-07-0039&rfr_id=info:sid/en.wikipedia.org:HOOK3" class="Z3988">

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