Hepatitis C virus envelope glycoprotein E2

HCV genome

E2 is a viral structural protein found in the hepatitis C virus.[1][2] It is present on the viral envelope and functions as a host receptor binding protein, mediating entry into host cells. It is a key target for the design of entry inhibitors and vaccine immunogens.[3]

## References[edit]

1. ^ Garcia JE, Puentes A, Súarez J, López R, Vera R, Rodríguez LE, Ocampo M, Curtidor H, Guzman F, Urquiza M, Patarroyo ME (2002). "Hepatitis C virus (HCV) E1 and E2 protein regions that specifically bind to HepG2 cells". Journal of Hepatology. 36 (2): 254–62. doi:10.1016/S0168-8278(01)00262-8. PMID 11830338.
2. ^ Bartosch B, Dubuisson J, Cosset FL (2003). "Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes". The Journal of Experimental Medicine. 197 (5): 633–42. doi:10.1084/jem.20021756. PMC 2193821. PMID 12615904.
3. ^ Kong L, Giang E, Nieusma T, Kadam RU, Cogburn KE, Hua Y, Dai X, Stanfield RL, Burton DR, Ward AB, Wilson IA, Law M (2013). "Hepatitis C virus E2 envelope glycoprotein core structure". Science. 342 (6162): 1090–4. Bibcode:2013Sci...342.1090K. doi:10.1126/science.1243876. PMC 3954638. PMID 24288331.

* v
* t
* e

Viral proteins (early and late)

DNA|

| linear ds-DNA
(Duplodnaviria,
Varidnaviria)|

| Herpes simplex|

| VSPs:|

| capsid:|

* HHV capsid portal protein
* Herpesvirus glycoprotein B

|

VNPs:|

* vmw65
* ICP8
* ICP34.5
* ICP47

Vaccinia|

| VNPs:|

* B13R

|

Adenoviridae|

| VNPs:|

* E1A
* E1B

|

circular ds-DNA
(Duplodnaviria,
Varidnaviria?)|

| Epstein–Barr|

| VSPs:|

* LMP-1
* LMP-2

|

VNPs:|

* EBNA-1
* EBNA-2
* EBNA-3

ncRNA:|

* EBER

Baculoviridae|

| VNPs:|

* Early 35 kDa protein

|

other
(Riboviria,
Monodnaviria)|

| Polyomaviridae
(SV40, MPyV, MCPyV, HaPyV)
(non-enveloped circular ds-DNA)|

| VSPs:|

| capsid:|

* VP1
* VP2 and VP3

|

VNPs:|

| oncoprotein:|

* STag
* MTag
* LTag (SV40 Tag)

|

* Agnoprotein

Hepatitis B
(circular partially ds-DNA)|

| VSPs:|

* HBsAg
* HBcAg

* HBeAg

|

VNPs:|

* HBx
* Hepatitis B virus DNA polymerase

RNA|

| ds-RNA
(Riboviria)|

| Rotavirus
(Duplornaviricota)|

| VNPs:|

* NSP1
* NSP2
* NSP3
* NSP4
* NSP5
* NSP6

|

Rhinov., Polio, Hep A,
etc. (Pisuviricota)|

| VNPs:|

* VPg

|

ss-RNA
positive-sense
(Riboviria)|

| Hepatitis C
(Kitrinoviricota)|

| VSPs:|

* viral envelope
* E1
* E2

|

VNPs:|

* P7
* NS2
* NS3
* NS4A
* NS4B
* NS5A
* NS5B

SARS-CoV-2
(Pisuviricota)|

| VSPs:|

* viral envelope
* Spike
* Envelope
* Membrane
* Nucleocapsid

|

VNPs:|

* ORF1ab
* 3C-like protease (NS5)
* ORF3a
* ORF3b
* ORF3c
* ORF3d
* ORF6
* ORF7a
* ORF7b
* ORF8
* ORF9b

ss-RNA
negative-sense
(Negarnaviricota)|

| Influenza virus|

| VSPs:|

| capsid:|

* matrix protein
* M1 protein
* viral envelope
* M2 protein

|

glycoprotein:|

* Influenza hemagglutinin
* Neuraminidase
* HA-tag

VNPs:|

* NS1

Parainfluenza|

| VSPs:|

| glycoprotein:|

* Parainfluenza hemagglutinin-neuraminidase

|

Mumps|

| VSPs:|

| glycoprotein:|

* Mumps hemagglutinin-neuraminidase

|

Measles|

| VSPs:|

| glycoprotein:|

* Measles hemagglutinin

|

RSV|

| VSPs:|

| glycoprotein:|

* Respiratory syncytial virus G protein

|

Zaire ebolavirus|

| VSPs:|

| capsid:|

* matrix protein
* VP40
* VP24

|

Indiana vesiculovirus|

| VSPs:|

| capsid:|

* matrix protein
* Vesiculovirus matrix proteins

|

RT|

| Structure and genome of HIV|

| VSPs:|

* gag
* p24
* pol
* Integrase
* Reverse transcriptase
* HIV-1 protease
* env
* gp120
* gp41

|

VRAPs:|

* transactivators
* Tat
* Rev
* Vpr
* Nef
* Vif
* Vpu or Vpx

Multiple

*     * Rous sarcoma virus
* murine leukemia virus

| Fusion protein|

| oncoprotein:|

* Gag-onc fusion protein

|

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|

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