Holin superfamily VI

The Holin superfamily VI is a superfamily of integral membrane transport proteins. It is one of the seven different holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members.

The Holin superfamily VI includes two TC families:[1]

* 1.E.12 \- The φAdh Holin (φAdh Holin) Family
* 1.E.26 \- The Holin LLH (Holin LLH) Family

Superfamily VI includes families with members only from Bacillota. These proteins appear to have one N-terminal transmembrane segment (TMS), followed by an amphipathic, weakly hydrophobic peak that was not predicted to be transmembrane by the topological programs used by Reddy and Saier (2013).[2] The average sizes of the members of the two families belonging to the Holin superfamily VI are 135 ± 11 and 130 ± 26 amino acyl residues (aas), respectively.[2]

## See also

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* Holin
* Lysin
* Transporter Classification Database

## References

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1. ^ "Holin Superfamily VI". Transporter Classification Database. Retrieved 2016-03-20.
2. ^ a b Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (11): 2654–2671\. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191.

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