Howard Hughes Medical Institute

American non-profit medical research organization

Howard Hughes Medical Institute

Founded| 1953; 72 years ago (1953)
Founder| Howard Hughes
Focus| Biological and Medical research and Science Education
Location|

* Chevy Chase, Maryland, U.S.

Coordinates| 38°59′55″N 77°4′47″W﻿ / ﻿38.99861°N 77.07972°W﻿ / 38.99861; -77.07972
Method| Laboratories, Funding

Key people

* Erin O'Shea (President)

Revenue| -US$2.303 billion[1] (due to losses on investments) (2022)
Expenses| US$853 million[1] (2022)
Endowment| US$24 billion[1]
Employees| 2,300 (2022)[2]
Website| hhmi.org

The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia.[3][4] It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer,[5] film director, and philanthropist, known during his lifetime as one of the most financially successful individuals in the world. It is one of the largest private funding organizations for biological and medical research in the United States. HHMI spends about $1 million per HHMI Investigator per year, which amounts to annual investment in biomedical research of about $825 million.

The institute has an endowment of $22.6 billion, making it the second-wealthiest philanthropic organization in the United States and the second-best-endowed medical research foundation in the world.[6] HHMI is the former owner of the Hughes Aircraft Company, an American aerospace firm that was divested to various firms over time.

## History

[edit]

The institute was formed with the goal of basic research including trying to understand, in Hughes's words, "the genesis of life itself." Despite its principles, in the early days it was generally viewed as a tax haven for Hughes's huge personal fortune. Hughes was HHMI's sole trustee and he transferred his stock of Hughes Aircraft to the institute, in effect turning the large defense contractor into a tax-exempt charity. For many years the Institute grappled with maintaining its non-profit status; the Internal Revenue Service challenged its "charitable" status which made it tax exempt. Partly in response to such claims, starting in the late 1950s it began funding 47 investigators doing research at eight different institutions; however, it remained a modest enterprise for several decades.[citation needed]

The institute was initially located in Miami, Florida, in 1953. Hughes's internist, Verne Mason, who treated Hughes after his 1946 plane crash, was chairman of the institute's medical advisory committee.[7] By 1975, Hughes was sole trustee of the Howard Hughes Medical Institute, which in turn owned all the stock of the Hughes Aircraft Company.[8]

In 1969, United States Congressman Wright Patman "complained that the Hughes foundation was a tax‐evasion device," noting that the institute spent only $5.7 million for its operations between 1954 and 1961, a period during which Hughes Aircraft accumulated $76.9 million in profits. By 1975, it had also avoided certain stipulations of the 1969 reform act for charitable institutions due to legal filings by Hughes to change its operational status, with his objections going directly to the White House.[9]

The institute moved to Coconut Grove, Florida, in the mid-1970s and then to Bethesda, Maryland, in 1976.[10]

In 1993, the institute moved to its headquarters in Chevy Chase, Maryland.[11]

HHMI founder Howard Hughes.

It was not until after Hughes's death in 1976 that the institute's profile increased from an annual budget of $4 million in 1975 to $15 million in 1978 and prior to Hughes Aircraft sale the number had peaked to $200 million per year. At the time of the sale Hughes Aircraft employed 75,000 people and vast amounts of money from the approximate annual revenue of $6 billion were put into Hughes Aircraft internal research and development rather than the medical institute. Most of the money for the medical institute came from the operations at Ground System Group responsible for providing Air Defense Systems to NATO, Pacific Rim, and the USA. In this period it focused its mission on genetics, immunology, and molecular biology. Since Hughes died without a will as the sole trustee of the HHMI, the institute was involved in lengthy court proceedings to determine whether it would benefit from Hughes's fortune. In April 1984, a court appointed new trustees for the institute's holdings.[12]

In January 1985 the trustees announced they would sell Hughes Aircraft by private sale or public stock offering. On June 5, 1985 General Motors (GM) was announced as the winner of a secretive five-month, sealed-bid auction. The purchase was completed on December 20, 1985, for an estimated $5.2 billion, $2.7 billion in cash and the rest in 50 million shares of GM Class H stock. The proceeds caused the institute to grow dramatically.

HHMI completed the building of the Janelia Research Campus in Ashburn, Virginia in October 2006. It is modeled after AT&T's Bell Labs and the Medical Research Council's Laboratory of Molecular Biology. With a main laboratory building nearly 1,000 feet (300 m) long, it contains 760,000 square feet (71,000 m2) of enclosed space, used primarily for research. The campus also features apartments for researchers.

In 2007, HHMI and the publisher Elsevier announced they have established an agreement to make author manuscripts of HHMI research articles published in Elsevier and Cell Press journals publicly available six months following final publication. The agreement takes effect for articles published after September 1, 2007.

In 2008, the Trustees of the Howard Hughes Medical Institute selected Robert Tjian its new president.

In 2009, HHMI awarded fifty researchers, as part of the HHMI Early Career Scientist Competition.[citation needed]

In 2014, the institute created a new round of its primary award competition, for a total of $150 million in award money from 2015 to 2012.[13] The institute is expanding the Ashburn campus in 2019.[14]

In 2016, the HHMI Trustees selected Erin K. O'Shea, a previous Vice President and Chief Scientific Officer at the institute, the new president of HHMI.[15]

In 2022, HHMI began to require immediate open access to publications from its research.[16]

In 2023, HHMI was sued by Vivian Cheung for disability discrimination.[17] HHMI won the suit in Maryland State Court and Dr. Cheung appealed to the Maryland Appellate Court.[18]

In 2025, HHMI cancelled their Inclusive Excellence 3 (IE3) program, which was a 6-year (2022–2028) $8.8 million award they had committed to the IMPACT STEM Network, which sought to enhance undergraduate science education and research.[19][20]

## Assets

[edit]

As of 2017[update] the Howard Hughes Medical Institute had assets of $22,588,928,000.[1]

### Funding details

[edit]

Funding details as of 2017[update]:[1] |

Revenue and support as of 2017: $2,382,777,000

1. Interest, dividends, and other income from investments (8.1%)
2. Realized gains on investment and derivative contracts, net (52.7%)
3. Change in unrealized gains/(losses) of investments and derivative contracts (39.2%)

Expenses as of 2017: $936,514,000

1. Medical research (70.4%)
2. Science education and other scientific programs (12.8%)
3. General and administrative (9.8%)
4. Interest expense (7%)

|
|

## See also

[edit]

* List of wealthiest charitable foundations
* Main category: Howard Hughes Medical Investigators

## References and notes

[edit]

1. ^ a b c d e "Howard Hughes Medical Institute" (PDF). Howard Hughes Medical Institute. 17 November 2022. Archived (PDF) from the original on 2 April 2023. Retrieved 7 August 2023.
2. ^ "Press Room | HHMI". www.hhmi.org. Archived from the original on 2024-07-05. Retrieved 2024-07-01.
3. ^ "Chevy Chase CDP, Maryland Archived 2011-06-06 at the Wayback Machine." U.S. Census Bureau. Retrieved on March 12, 2010.
4. ^ "Contact Archived 2013-06-21 at the Wayback Machine." Howard Hughes Medical Institute. Retrieved on March 12, 2010.
5. ^ "Howard R. Hughes | Howard R. Hughes College of Engineering | University of Nevada, Las Vegas". www.unlv.edu. 20 July 2011. Archived from the original on 2020-01-01. Retrieved 2020-04-10.
6. ^ "Howard Hughes Medical Institute | 2013 Year in Review". Archived from the original on August 22, 2014.
7. ^ Dr. Verne Mason. Miami Physician. Howard Hughes aide dies. Also treated Pershing. The New York Times. November 17, 1965.
8. ^ Dietrich, Noah; Thomas, Bob (1972). Howard, The Amazing Mr. Hughes. Greenwich: Fawcett Publications, Inc. p. 268.
9. ^ "Howard Hughes, beyond the law", The New York Times, Sep 14, 1975, archived from the original on January 4, 2019, retrieved January 3, 2019
10. ^ Wernick, Ellen D. "Howard Hughes Medical Institute". Answers.com. Archived from the original on 2009-04-07. Retrieved 2009-08-30.
11. ^ "Howard Hughes Medical Institute History". Funding Universe. Archived from the original on 15 July 2014. Retrieved 15 June 2014.
12. ^ Note: the original trustees were: Helen K. Copley, Donald S. Fredrickson, M.D., Frank William Gay, James H. Gilliam, Jr., Esq., Hanna H. Gray, Ph.D., William R. Lummis, Esq., Irving S. Shapiro, Esq., George W. Thorn, M.D.
13. ^ "Howard Hughes Medical Institute Offers $150-Million in New Awards", The Chronicle of Higher Education, Jan 15, 2014, archived from the original on January 4, 2019, retrieved January 3, 2019
14. ^ "Howard Hughes Medical Institute to expand Loudoun research campus", Washington Business Journal, Jan 3, 2019
15. ^ "The week in science: 5–11 February 2016". Nature. 530 (7589). People: HHMI president. February 10, 2016. Bibcode:2016Natur.530..134.. doi:10.1038/530134a.
16. ^ "HHMI, one of the largest research philanthropies, will require immediate open access to papers". AAAS. Oct 1, 2020. Archived from the original on March 7, 2023. Retrieved March 7, 2023.
17. ^ Wadman, Meredith (December 4, 2023). "Trial puts Howard Hughes Medical Institute—and disabled scientists—in the spotlight". Science. Retrieved 5 July 2024.
18. ^ "Court Schedule | Maryland Courts". www.courts.state.md.us. Retrieved 2025-01-24.
19. ^ Oza, Anil (2025-02-07). "Researchers 'stunned' after HHMI abruptly cancels program to make science more inclusive". STAT. Retrieved 2025-02-07.
20. ^ "HHMI kills program aimed at boosting inclusivity in STEM education". www.science.org. Retrieved 2025-02-07.

## External links

[edit]

* 60 Minutes news feature "Howard Hughes: Patron Of Science?"

* v
* t
* e

Howard Hughes

Aviation|

* Hughes Aircraft Company
* Spruce Goose
* H-1 Racer
* Hughes Airwest
* Trans World Airlines
* Hughes Helicopters

Films directed|

* Hell's Angels (1930)
* The Outlaw (1943)

Films produced|

* Two Arabian Knights (1927)
* The Racket (1928)
* The Mating Call (1928)
* The Front Page (1931)
* Cock of the Air (1932)
* Sky Devils (1932)
* Scarface (1932)
* Behind the Rising Sun (1943)
* The Sin of Harold Diddlebock (1947)
* The Tattooed Stranger (1950)
* Vendetta (1950)
* His Kind of Woman (1951)
* The Whip Hand (1951)
* Two Tickets to Broadway (1951)
* Macao (1952)
* The Las Vegas Story (1952)
* Second Chance (1953)
* The French Line (1954)
* Son of Sinbad (1955)
* The Conqueror (1956)
* Jet Pilot (1957)

Popular culture|

* The Amazing Howard Hughes (1977)
* Melvin and Howard (1980)
* The Rocketeer (1991)
* The Aviator (2004)
* Rules Don't Apply (2016)

Related|

* Jean Peters (wife)
* Howard R. Hughes Sr. (father)
* Hughes Tool Company
* Howard Hughes Medical Institute
* Desert Inn
* Melvin Dummar
* Summa Corporation
* Howard Hughes Holdings

Authority control databases

International|

* ISNI
* VIAF

National|

* Germany
* United States
* Israel

Academics|

* CiNii

People|

* ISIL

Other|

* SNAC
* Yale LUX

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