Huda Zoghbi

Lebanese scientist

Huda Yahya Zoghbi[2]

Born|

Huda El-Hibri

1954 (age 69-70)[3]

Beirut, Lebanon

Alma mater| Baylor College of Medicine
Meharry Medical College
American University of Beirut
Known for| Research in Rett syndrome and spinocerebellar ataxia type 1
Spouse| William Zoghbi[4]
Awards| Texas Women Hall of Fame (2008)
Gruber Prize in Neuroscience (2011)
Pearl Meister Greengard Prize (2013)
Dickson Prize (2013)
Shaw Prize in Life Science and Medicine (2016)
Canada Gairdner International Award (2017)
Breakthrough Prize in Life Sciences (2017)
Brain Prize (2020)
Scientific career
Fields| Genetics
Neuroscience
Institutions| Regeneron Pharmaceuticals[1]
Baylor College of Medicine
Howard Hughes Medical Institute
Texas Children's Hospital

Huda Yahya Zoghbi (Arabic: هدى الهبري الزغبي Hudā al-Hibrī az-Zughbī; born 1954), born Huda El-Hibri,[3] is a Lebanese-born American geneticist, and a professor at the Departments of Molecular and Human Genetics, Neuroscience and Neurology at the Baylor College of Medicine. She is the director of the Jan and Dan Duncan Neurological Research Institute.[5][6] She became the editor of the Annual Review of Neuroscience as of 2018.[7]

Her work helped elucidate the genes and genetic mechanisms responsible for a number of devastating neurological disorders, such as Rett syndrome and spinocerebellar ataxia type 1.[8] Zoghbi's discoveries have provided new ways of thinking about other neurological disorders such as Parkinson's disease, Alzheimer's, autism and intellectual disability, which could lead to new therapeutics and better, more efficient treatments.[9][10]

In 2017, she was awarded the Canada Gairdner International Award and the Breakthrough Prize in Life Sciences.

## Early life and education[edit]

Huda Zoghbi was born in Beirut, Lebanon in 1954, and raised in Beirut. She loved reading works by William Shakespeare, Jane Austen and William Wordsworth in high school and intended to pursue literature at university.[11] Her mother convinced her to study biology instead, on the grounds that 'a woman growing up in the Middle East should pick a career ensuring independence and security, while she can always write on the side'.[12][11] Zoghbi was admitted as a biological sciences major at the American University of Beirut (AUB) in 1973 and entered the university's medical school 2 years later.[11]

The Lebanese Civil War began in 1976 during her first year of medical school. Although she and her classmates decided to stay at the university, after her brother was injured by shrapnel, their parents sent them to live with their sister in Austin, Texas, with plans to return the following summer.[11][13] The war, however, raged on, and Zoghbi was under the impression that school terms at American medical schools began in October, as was the case with Lebanese schools. However, in October, it was confirmed that she was still unable to return to Lebanon due to the war, and US medical schools had begun their fall term 2 months earlier. Her family friends in America suggested she apply to Vanderbilt University. Vanderbilt did not accept transfer students, but recommended Meharry Medical College instead; Meharry accepted her on the spot.[13] Despite her continued desire to return to Lebanon the next summer, on the advice of professors at AUB, she stayed at Meharry and earned an MD degree in 1979, after which she joined the Texas Children's Hospital at the Baylor College of Medicine as a pediatric resident.[11]

Zoghbi initially intended to specialise in pediatric cardiology, out of an interest in the heart. During her rotation at pediatric neurology, Marvin Fishman, the head of the division, convinced her that the brain was more interesting than the heart. She thus started a 3-year term as a postdoctoral researcher in pediatric neurology after she finished her residency in 1982.

## Career[edit]

Huda Zoghbi, Kavli Prize Laureate, interviews at Munch Museum, Oslo, Norway. Photo: Thomas Eckhoff

From 1982 to 1985, Zoghbi was a postdoctoral researcher in pediatric neurology at the Baylor College of Medicine. She became an assistant professor at the Department of Pediatrics at Baylor in 1988, and was successively promoted to associate professor in 1991 and professor in 1994.[14] At present, Zoghbi is a professor at the Department of Molecular and Human Genetics at Baylor, with appointments as a professor at the Department of Neuroscience and the Department of Pediatrics Section of Neurology and Developmental Neuroscience, the Ralph Feigin, M.D. Endowed Chair, the director of the Texas Children's Hospital Jan and Dan Duncan Neurological Research Institute, a member of the Dan L. Duncan Comprehensive Cancer Center at Baylor, and an investigator at the Howard Hughes Medical Institute.[5] She is also a member of the board of directors of Regeneron Pharmaceuticals.[1] She also served on the Life Sciences jury for the Infosys Prize in 2014.

## Research[edit]

In 1983, Zoghbi learnt of Rett syndrome from Bengt Hagberg's account in Annals of Neurology. The paper allowed Zoghbi to diagnose a five-year-old she treated at Texas Children's Hospital, and a week later she saw another patient with the same set of symptoms. When she investigated medical records, she found more cases of Rett syndrome that had been misdiagnosed. This sparked her interest in Rett syndrome, at a time when there was no report of the disease in the US.[3] An article she published in 1985[15] attracted many Rett syndrome patients to Texas Children's Hospital, giving her access to a large number of cases.[16]

Since most patients of Rett syndrome were girls, and symptoms were very consistent across patients, Zoghbi believed genetics were involved in the disease process.[3] This led her to join Arthur Beaudet's group in 1985, after finishing her term as a postdoctoral researcher, for training in genetics and molecular biology.[13] Beaudet advised against Rett syndrome as her research project since its mode of inheritance was still not obvious, and recommended a more approachable problem – spinocerebellar ataxia type 1, a dominantly inherited neurological disorder. In 1988, Zoghbi left Beaudet's group and founded her own lab at Baylor.[11] In addition to her research on spinocerebellar ataxia type 1 and Rett syndrome, Zoghbi is participating in a joint research collaboration into CDKL5 Deficiency Disorder, funded by the Loulou Foundation, Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children's Hospital[17]

### Spinocerebellar ataxia type 1[edit]

Following the establishment of her own lab, Zoghbi continued studying spinocerebellar ataxia type 1 (SCA1), in collaboration with Harry Orr from the University of Minnesota.[18] On the same day, 8 April 1993, both Zoghbi and Orr identified ATXN1 as the gene responsible for SCA1.[13] They determined that the disease was caused by an expansion of the glutamine-encoding CAG trinucleotide repeat in this gene, and that the younger the age of onset, the longer the CAG repeat.[19] Further work by Zoghbi, Orr and their teams demonstrated that the misfolding, aggregation, and proteasomal degradation of the protein product of this gene, Ataxin 1, played a role in the disorder.[20]

### Math1[edit]

After solving the etiology of spinocerebellar ataxia type 1, Zoghbi began studying animal genes related to balance. As Baylor's Hugo J. Bellen described the role of the atonal gene in balance in fruit flies, Zoghbi chose to study its mammalian homolog. A member of her lab successfully cloned the mouse homolog, Math1, in 1996.[21] Her team went on to find that, in addition to its involvement in balance and coordination, Math1 is also crucial to hearing,[22] the formation of secretory cells in the gut.[23], and neonatal respiratory rhythm and chemosensitivity in the adult brain by regulating the development of a group of hindbrain neurons.[24] Her lab has also shown that aberrant activation of Math1 could lead to medulloblastoma, a common childhood brain tumor, and that mice which did not express Math1, did not develop the tumor.[25]

### Rett syndrome[edit]

Ever since Zoghbi was introduced to Rett syndrome early in her career, she has been working on the disorder alongside other research, despite the lack of enthusiasm from her colleagues, fellow researchers and funding agencies. The main reason is that very few individuals and even fewer families are available for investigation. In the 1990s, she collaborated with Uta Francke from Stanford University to identify the gene responsible for Rett syndrome. In 1992, she narrowed down the target to a section of the X chromosome.[26] In 1999, a postdoctoral researcher in Zoghbi's lab identified MECP2 as the causative gene.[27] The MECP2 protein binds methylated cytosine (5-methylcytosine) in CpG sites, and is indispensable for almost all brain cells.[13] In the paper, she and her team demonstrated that Rett syndrome was an X-linked dominant disorder, meaning that when 1 of the 2 copies of the MECP2 gene is abnormal, Rett syndrome will result.[12]

Zoghbi's team keeps studying MECP2, and discovered in 2004 that overexpressing the protein in mouse led to an autism-like neurological disorder.[28] In 2009, she found mice deficient of the Mecp2 gene (the mouse homolog of human MECP2) had lower levels of norepinephrine, dopamine and serotonin,[29] consistent with her clinical observations of patients of Rett syndrome in 1985. Recently, Zoghbi confirmed that the MECP2 protein also bound 5-methylcytosine not in CpG sites,[30] and that restoring the level of MECP2 protein in a subset of neurons was sufficient to rescue some symptoms of Rett syndrome.[31]

### Ataxin-1 link to Alzheimer's[edit]

After linking the gene Ataxin-1 to SCA1, Zoghbi's lab was approached by Dr. Jaehong Suh of the Massachusetts General Hospital's MassGeneral Institute for Neurodegenerative Disease to investigate the connection between ataxin-1 gene and Alzheimer's disease.[32] The subsequent study found that loss of ataxin-1 elevates BACE1 expression and Aβ pathology in mouse models, rendering it a potential contributor to risk and pathogenesis of Alzheimer's disease.[33]

## Awards and honors[edit]

* 2022 – Kavli Prize in Neuroscience.[34]
* 2020 – Brain Prize[35]
* 2019 – Victor A. McKusick Leadership Award, American Society of Human Genetics[36]
* 2018 – Member of the American Academy of Arts and Sciences[37]
* 2018 – Ross Prize in Molecular Medicine, Molecular Medicine[38]
* 2018 – National Order of the Cedar, Lebanon[39]
* 2017 – Breakthrough Prize in Life Sciences[40]
* 2017 – Canada Gairdner International Award[41]
* 2016 – Jessie Stevenson Kovalenko Medal[42]
* 2016 – Shaw Prize in Life Science and Medicine
* 2015 – Mechthild Esser Nemmers Prize in Medical Science, Northwestern University
* 2015 – Vanderbilt Prize in Biomedical Science, Vanderbilt University School of Medicine
* 2015 – Javits Neuroscience Investigator Award, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health
* 2015 – American Task Force for Lebanon Award
* 2015 – Mortimer D. Sackler, M.D. Prize for Distinguished Achievement in Developmental Psychobiology, Weill Cornell Medicine and Columbia University College of Physicians and Surgeons[43]
* 2014 – Honorary Doctor of Medical Sciences, Yale University[44]
* 2014 – March of Dimes Prize in Developmental Biology
* 2014 – Edward M. Scolnick Prize in Neuroscience, McGovern Institute for Brain Research, Massachusetts Institute of Technology[45]
* 2013 – Dickson Prize in Medicine, University of Pittsburgh
* 2013 – Pearl Meister Greengard Prize, Rockefeller University
* 2011 – Gruber Prize in Neuroscience[5]
* 2011 – Vita and Lee Lyman Dewey Tuttle Brookwood Legacy Award for Excellence and Partnership in Medicine, Brookwood Community [46]
* 2009 – International Rett Syndrome Foundation's Circle of Angels Research Award
* 2009 – Vilcek Prize for Biomedical Research, Vilcek Foundation
* 2009 – Marion Spencer Fay Award, Drexel University College of Medicine[5]
* 2009 – Cathedra Laboris, University of Monterrey[47]
* 2008 – Honorary Doctor of Science, Meharry Medical College
* 2008 – Texas Women's Hall of Fame[5]
* 2007 – Perl-UNC Neuroscience Prize[48]
* 2007 – Massachusetts Institute of Technology Arab Students' Organization Science and Technology Lifetime Achievement Award [49]
* 2007 – Honorary Doctor of Science, Middlebury College
* 2007 – Robert J. and Claire Pasarow Foundation Award in Neuropsychiatry Research
* 2004 – Member of the National Academy of Sciences
* 2004 – Neuronal Plasticity Prize, Ipsen Foundation
* 2004 – Marta Philipson Award in Pediatrics, Philipson Foundation for Research [5]
* 2002 – Fellow of the American Association for the Advancement of Science
* 2002 – Raymond D. Adams Lectureship, American Neurological Association[43]
* 2001 – Bernard Sachs Award, Society for Pediatric Research
* 2000 – Member of the National Academy of Medicine (formerly the Institute of Medicine)
* 1998 – Sidney Carter Award, American Academy of Neurology
* 1998 – Soriano Lectureship, American Neurological Association
* 1998 – Javits Award, NINDS, National Institutes of Health
* 1996 – E. Mead Johnson Award, Society of Pediatric Research
* 1995 – Kilby International Award [5]

## Personal life[edit]

Zoghbi met her husband, William Zoghbi when they were medical students in the American University of Beirut. In 1977, she continued her medical school study in Meharry Medical College, and William transferred to Meharry next year. They both had their residencies in the Baylor College of Medicine after graduation. They married in 1980 and have 2 children.[4] William is the chief of the Department of Cardiology at Houston Methodist Hospital.[50]

## References[edit]

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2. ^ Cha, Ariana Eunjung (4 December 2016). "Silicon Valley's 'Nobels': Mega-prizes awarded for work in brains, the origins of life and gravitational waves". Washington Post. Retrieved 13 December 2018.[dead link]
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21. ^ Ben-Arie, Nissim; McCall, Alanna E.; Berkman, Scott; Eichele, Gregor; Bellen, Hugo J.; Zoghbi, Huda Y. (1 September 1996). "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis". Human Molecular Genetics. 5 (9): 1207–1216. doi:10.1093/hmg/5.9.1207. hdl:11858/00-001M-0000-0010-50D1-1. PMID 8872459.
22. ^ Bermingham, Nessan A.; Hassan, Bassem A.; Price, Steven D.; Vollrath, Melissa A.; Ben-Arie, Nissim; Eatock, Ruth A.; Bellen, Hugo J.; Lysakowski, Anna; Zoghbi, Huda Y. (11 June 1999). "Math1: An Essential Gene for the Generation of Inner Ear Hair Cells". Science. 284 (5421): 1837–1841. doi:10.1126/science.284.5421.1837. PMID 10364557.
23. ^ Yang, Qi; Bermingham, Nessan A.; Finegold, Milton J.; Zoghbi, Huda Y. (7 December 2001). "Requirement of Math1 for secretory cell lineage commitment in the mouse intestine". Science. 294 (5549): 2155–2158. Bibcode:2001Sci...294.2155Y. doi:10.1126/science.1065718. PMID 11739954. S2CID 27540123.
24. ^ Huang, Wei-Hsiang; Tupal, Srinivasan; Huang, Teng-Wei; Ward, Christopher S.; Neul, Jeffery L.; Klisch, Tiemo J.; Gray, Paul A.; Zoghbi, Huda Y. (2012). "Atoh1 Governs the Migration of Postmitotic Neurons that Shape Respiratory Effectiveness at Birth and Chemoresponsiveness in Adulthood". Neuron. 75 (5). Elsevier BV: 799–809. doi:10.1016/j.neuron.2012.06.027. ISSN 0896-6273. PMC 3464459. PMID 22958821.
25. ^ Flora, Adriano; Klisch, Tiemo J.; Schuster, Gabriele; Zoghbi, Huda Y. (4 December 2009). "Deletion of Atoh1 Disrupts Sonic Hedgehog Signaling in the Developing Cerebellum and Prevents Medulloblastoma". Science. 326 (5958): 1424–1427. Bibcode:2009Sci...326.1424F. doi:10.1126/science.1181453. PMC 3638077. PMID 19965762.
26. ^ Ellison, Kimberley A.; Fill, Carolyn P.; Terwilliger, Joseph; DeGennaro, Louis J.; Martin-Gallardo, Antonia; Anvret, Maria; Percy, Alan K.; Ott, Jurg; Zoghbi, Huda Y. (Feb 1992). "Examination of X chromosome markers in Rett syndrome: exclusion mapping with a novel variation on multilocus linkage analysis". American Journal of Human Genetics. 50 (2): 278–287. PMC 1682446. PMID 1734712.
27. ^ Amir, Ruthie E.; Van den Veyver, Ignatia B.; Wan, Mimi; Tran, Charles Q.; Francke, Uta; Zoghbi, Huda Y. (1 October 1999). "Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2". Nature Genetics. 23 (2): 185–188. doi:10.1038/13810. PMID 10508514. S2CID 3350350.
28. ^ Collins, Ann L.; Levenson, Jonathan M.; Vilaythong, Alexander P.; Richman, Ronald; Armstrong, Dawna L.; Noebels, Jeffrey L.; Sweatt, J. David; Zoghbi, Huda Y. (6 September 2004). "Mild overexpression of MeCP2 causes a progressive neurological disorder in mice". Human Molecular Genetics. 13 (21): 2679–2689. doi:10.1093/hmg/ddh282. PMID 15351775.
29. ^ Samaco, Rodney C.; Mandel-Brehm, Caleigh; Chao, Hsiao-Tuan; Ward, Christopher S.; Fyffe-Maricich, Sharyl L.; Ren, Jun; Hyland, Keith; Thaller, Christina; Maricich, Stephen M.; Humphreys, Peter; Greer, John J.; Percy, Alan; Glaze, Daniel G.; Zoghbi, Huda Y.; Neul, Jeffrey L. (22 December 2009). "Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities". Proceedings of the National Academy of Sciences of the United States of America. 106 (51): 21966–21971. Bibcode:2009PNAS..10621966S. doi:10.1073/pnas.0912257106. PMC 2799790. PMID 20007372.
30. ^ Chen, Lin; Chen, Kaifu; Lavery, Laura A.; Baker, Steven A.; Shaw, Chad A.; Li, Wei; Zoghbi, Huda Y. (28 April 2015). "MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome". Proceedings of the National Academy of Sciences of the United States of America. 112 (17): 5509–5514. Bibcode:2015PNAS..112.5509C. doi:10.1073/pnas.1505909112. PMC 4418849. PMID 25870282.
31. ^ Ure, Kerstin; Lu, Hui; Wang, Wei; Ito-Ishida, Aya; Wu, Zhenyu; He, Ling-jie; Sztainberg, Yehezkel; Chen, Wu; Tang, Jianrong; Zoghbi, Huda Y. (21 June 2016). "Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome". eLife. 5: e14198. doi:10.7554/eLife.14198. PMC 4946897. PMID 27328321.
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34. ^ Kavli Prize 2022
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41. ^ "Huda Y Zoghbi". Gairdner Foundation. Archived from the original on 1 August 2020. Retrieved 14 December 2018.
42. ^ "Jessie Stevenson Kovalenko Medal". National Academy of Sciences. Archived from the original on 27 May 2016. Retrieved 14 December 2018.
43. ^ a b "Huda Yahya Zoghbi". Virtually Integrated Institutions for Clinical and Translational Research. Archived from the original on 21 October 2020. Retrieved 14 December 2018.
44. ^ "Yale awards 12 honorary degrees at 2014 graduation". Yale University. 19 May 2014. Archived from the original on 12 March 2019. Retrieved 14 December 2018.
45. ^ Jennings, Charles (4 March 2014). "McGovern Institute to honor neurogenetics researcher Huda Zoghbi". McGovern Institute for Brain Research. Archived from the original on 21 February 2017. Retrieved 14 December 2018.
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49. ^ "Arab Students' Organization hosts awards". Massachusetts Institute of Technology. 12 April 2007. Archived from the original on 27 August 2020. Retrieved 3 December 2018.
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## External links[edit]

Wikimedia Commons has media related to Huda Zoghbi.

Scholia has an author profile for Huda Zoghbi.

* Huda Zoghbi on Charlie Rose

* v
* t
* e

Shaw Prize laureates

Astronomy|

* Jim Peebles (2004)
* Geoffrey Marcy and Michel Mayor (2005)
* Saul Perlmutter, Adam Riess and Brian Schmidt (2006)
* Peter Goldreich (2007)
* Reinhard Genzel (2008)
* Frank Shu (2009)
* Charles Bennett, Lyman Page and David Spergel (2010)
* Enrico Costa and Gerald Fishman (2011)
* David C. Jewitt and Jane Luu (2012)
* Steven Balbus and John F. Hawley (2013)
* Daniel Eisenstein, Shaun Cole and John A. Peacock (2014)
* William J. Borucki (2015)
* Ronald Drever, Kip Thorne and Rainer Weiss (2016)
* Simon White (2017)
* Jean-Loup Puget (2018)
* Edward C. Stone (2019)
* Roger Blandford (2020)
* Victoria Kaspi and Chryssa Kouveliotou (2021)
* Lennart Lindegren and Michael Perryman (2022)
* Matthew Bailes, Duncan Lorimer and Maura McLaughlin (2023)

Life science
and medicine|

* Stanley Norman Cohen, Herbert Boyer, Yuet-Wai Kan and Richard Doll (2004)
* Michael Berridge (2005)
* Xiaodong Wang (2006)
* Robert Lefkowitz (2007)
* Ian Wilmut, Keith H. S. Campbell and Shinya Yamanaka (2008)
* Douglas Coleman and Jeffrey Friedman (2009)
* David Julius (2010)
* Jules Hoffmann, Ruslan Medzhitov and Bruce Beutler (2011)
* Franz-Ulrich Hartl and Arthur L. Horwich (2012)
* Jeffrey C. Hall, Michael Rosbash and Michael W. Young (2013)
* Kazutoshi Mori and Peter Walter (2014)
* Bonnie Bassler and Everett Peter Greenberg (2015)
* Adrian Bird and Huda Zoghbi (2016)
* Ian R. Gibbons and Ronald Vale (2017)
* Mary-Claire King (2018)
* Maria Jasin (2019)
* Gero Miesenböck, Peter Hegemann and Georg Nagel (2020)
* Scott D. Emr (2021)
* Paul A. Negulescu and Michael J. Welsh (2022)
* Patrick Cramer and Eva Nogales (2023)

Mathematical
science|

* Shiing-Shen Chern (2004)
* Andrew Wiles (2005)
* David Mumford and Wentsun Wu (2006)
* Robert Langlands and Richard Taylor (2007)
* Vladimir Arnold and Ludwig Faddeev (2008)
* Simon Donaldson and Clifford Taubes (2009)
* Jean Bourgain (2010)
* Demetrios Christodoulou and Richard S. Hamilton (2011)
* Maxim Kontsevich (2012)
* David Donoho (2013)
* George Lusztig (2014)
* Gerd Faltings and Henryk Iwaniec (2015)
* Nigel Hitchin (2016)
* János Kollár and Claire Voisin (2017)
* Luis Caffarelli (2018)
* Michel Talagrand (2019)
* Alexander Beilinson and David Kazhdan (2020)
* Jean-Michel Bismut and Jeff Cheeger (2021)
* Noga Alon and Ehud Hrushovski (2022)
* Vladimir Drinfeld and Shing-Tung Yau (2023)

* v
* t
* e

Texas Women's Hall of Fame

1980s

| 1984|

* Christia Adair
* Kate Atkinson Bell
* Vivian Castleberry
* Lila Cockrell
* Clotilde Pérez García
* Jeane Porter Hester
* Oveta Culp Hobby
* Mary Evelyn Blagg Huey
* Sarah T. Hughes
* Lady Bird Johnson
* Barbara Jordan
* Amy Freeman Lee

|

1985|

* Benjy Frances Brooks
* Patricia Happ Buffler
* Liz Carpenter
* Grace Woodruff Cartwright
* Helen Farabee
* Maria Elena Flood
* Willie Lee Glass
* Lydia Mendoza
* Jenny Lind Porter
* Louise Raggio
* Ann Richards
* Edna Gardner Whyte

1986|

* Anne Armstrong
* Mary Kay Ash
* Caro Crawford Brown
* Alicia Chacon
* Jody Conradt
* Margaret Cousins
* Wilhelmina Ruth Delco
* Frances Goff
* Mary Lavinia Griffith
* May Owen
* Sally Ride
* Ada Simond
* Hermine Tobolowsky

1987|

* Lucy G. Acosta
* Ruth Sharp Altshuler
* Margaret Harris Amsler
* Johnnie Benson
* Tommie Clack
* Kim Dawson
* Lillian Dunlap
* Elithe Hamilton Kirkland
* Donna Lopiano
* Katie Sherrod
* Donnya Stephens
* Dora Dougherty Strother
* Mary Nan West

1988|

* Nancy Brinker
* Margaret Pease Harper
* Ninfa Laurenzo
* Lane Murray
* Louise Ritter
* Ruth Taubert Seeger
* Bert Kruger Smith
* Eleanor Tinsley

1989|

* Barbara Bush
* Judith Craven
* Gussie Nell Davis
* Margaret Swan Forbes
* L. Ruth Guy
* Terry Hershey
* Lucia Rede Madrid
* Jane Wetzel

1990s

| 1993|

* Linda Louise Craft
* Ernestine Glossbrenner
* Gabrielle Kirk McDonald
* Eleanor Montague
* Aaronetta Hamilton Pierce
* Gloria G. Rodriguez
* Annette Strauss

|

1994|

* Rosa Ramirez Guerrero
* Irma Rangel
* Mary Beth Rogers
* Bess Whitehead Scott
* Hallie Stillwell
* Francie Larrieu Smith
* Alvia Wardlaw
* Martha Wong
* Eleanor Anne Young

1996|

* Ebby Halliday Acers
* Rita Crocker Clements
* Zina Garrison
* Sybil Harrington
* Kay Bailey Hutchison
* Vassar Miller
* Helen Oujesky
* Ruby Lee Piester
* Dian Graves Stai
* S. Eva Singletary

1998|

* Norma Lea Beasley
* Shirley Thompson Carter
* Elizabeth Lyons Ghrist
* Kay Granger
* Dixie Melillo
* Diana Natalicio
* Marsha Sharp

2000s

| 2000|

* Tillie Burgin
* Carol Dinkins
* Anna Maria Farias
* Juliet V. García
* Glenna Goodacre
* Wendy Harpham
* Jinger L. Heath
* Dealey Herndon
* Mamie L. McKnight
* Jo Stewart Randel
* Judy Rankin

|

2002|

* Karen Hughes
* Mae Jemison
* Angela Murdaugh
* Ann Williams

2004|

* Susan Combs
* Trinidad Mendenhall
* Mary Meyers Rosenfield
* Sheryl Swoopes

2006|

* Amanda Dunbar
* Kathleen Foster
* Shirley Neeley
* Ellen Vitetta

2008|

* Elsa Murano
* Sandra Day O'Connor
* Carolyn Peterson
* Louise Hopkins Underwood
* Huda Zoghbi

2010s

| 2010|

* Nancy W. Dickey
* Erma Johnson Hadley
* Teresa Lozano Long
* Judy Castle Scott
* Pamela Willeford

|

2012|

* Barbara Smith Conrad
* Anne Corn
* Nina Godiwalla
* Harriet O'Neill
* Mary Saunders

2014|

* Nandita Berry
* Joanne Herring
* Kim Olson
* Anita Perry
* Ann Stuart
* Senfronia Thompson
* Deborah Tucker
* Carolyn Wright

2016|

* Emma Carter Browning
* Susie Hitchcock-Hall
* Ginger Kerrick
* Renu Khator
* Selena

2018|

* Simone Biles
* Laura Bush
* Vikki Carr
* Susan Dell
* Tammie Jo Shults
* Elizabeth Anne Sueltenfuss
* Judith Zaffirini

2020s

| 2021|

* Lauren Anderson
* Charlye O. Farris
* Dawn Ferrell
* Ofelia Vasquez-Philo
* Kendra Scott
* Elaine Stolte

|

2023|

* Leta Andrews
* Mary Horn
* Val LaMantia
* Opal Lee
* Lavinia Masters
* Antonietta Quigg
* Charlotte Sharp
* Elizabeth Suarez

* v
* t
* e

Breakthrough Prize laureates

Mathematics|

* Simon Donaldson, Maxim Kontsevich, Jacob Lurie, Terence Tao and Richard Taylor (2015)
* Ian Agol (2016)
* Jean Bourgain (2017)
* Christopher Hacon, James McKernan (2018)
* Vincent Lafforgue (2019)
* Alex Eskin (2020)
* Martin Hairer (2021)
* Takuro Mochizuki (2022)
* Daniel A. Spielman (2023)
* Simon Brendle (2024)

Fundamental
physics|

* Nima Arkani-Hamed, Alan Guth, Alexei Kitaev, Maxim Kontsevich, Andrei Linde, Juan Maldacena, Nathan Seiberg, Ashoke Sen, Edward Witten (2012)
* Special: Stephen Hawking, Peter Jenni, Fabiola Gianotti (ATLAS), Michel Della Negra, Tejinder Virdee, Guido Tonelli, Joseph Incandela (CMS) and Lyn Evans (LHC) (2013)
* Alexander Polyakov (2013)
* Michael Green and John Henry Schwarz (2014)
* Saul Perlmutter and members of the Supernova Cosmology Project; Brian Schmidt, Adam Riess and members of the High-Z Supernova Team (2015)
* Special: Ronald Drever, Kip Thorne, Rainer Weiss and contributors to LIGO project (2016)
* Yifang Wang, Kam-Biu Luk and the Daya Bay team, Atsuto Suzuki and the KamLAND team, Kōichirō Nishikawa and the K2K / T2K team, Arthur B. McDonald and the Sudbury Neutrino Observatory team, Takaaki Kajita and Yōichirō Suzuki and the Super-Kamiokande team (2016)
* Joseph Polchinski, Andrew Strominger, Cumrun Vafa (2017)
* Charles L. Bennett, Gary Hinshaw, Norman Jarosik, Lyman Page Jr., David Spergel (2018)
* Special: Jocelyn Bell Burnell (2018)
* Charles Kane and Eugene Mele (2019)
* Special: Sergio Ferrara, Daniel Z. Freedman, Peter van Nieuwenhuizen (2019)
* The Event Horizon Telescope Collaboration (2020)
* Eric Adelberger, Jens H. Gundlach and Blayne Heckel (2021)
* Special: Steven Weinberg (2021)
* Hidetoshi Katori and Jun Ye (2022)
* Charles H. Bennett, Gilles Brassard, David Deutsch, Peter W. Shor (2023)
* John Cardy and Alexander Zamolodchikov (2024)

Life sciences|

* Cornelia Bargmann, David Botstein, Lewis C. Cantley, Hans Clevers, Titia de Lange, Napoleone Ferrara, Eric Lander, Charles Sawyers, Robert Weinberg, Shinya Yamanaka and Bert Vogelstein (2013)
* James P. Allison, Mahlon DeLong, Michael N. Hall, Robert S. Langer, Richard P. Lifton and Alexander Varshavsky (2014)
* Alim Louis Benabid, Charles David Allis, Victor Ambros, Gary Ruvkun, Jennifer Doudna and Emmanuelle Charpentier (2015)
* Edward Boyden, Karl Deisseroth, John Hardy, Helen Hobbs and Svante Pääbo (2016)
* Stephen J. Elledge, Harry F. Noller, Roeland Nusse, Yoshinori Ohsumi, Huda Zoghbi (2017)
* Joanne Chory, Peter Walter, Kazutoshi Mori, Kim Nasmyth, Don W. Cleveland (2018)
* C. Frank Bennett and Adrian R. Krainer, Angelika Amon, Xiaowei Zhuang, Zhijian Chen (2019)
* Jeffrey M. Friedman, Franz-Ulrich Hartl, Arthur L. Horwich, David Julius, Virginia Man-Yee Lee (2020)
* David Baker, Catherine Dulac, Dennis Lo, Richard J. Youle [de] (2021)
* Jeffery W. Kelly, Katalin Karikó, Drew Weissman, Shankar Balasubramanian, David Klenerman and Pascal Mayer (2022)
* Clifford P. Brangwynne, Anthony A. Hyman, Demis Hassabis, John Jumper, Emmanuel Mignot, Masashi Yanagisawa (2023)
* Carl June, Michel Sadelain, Sabine Hadida, Paul Negulescu, Fredrick Van Goor, Thomas Gasser, Ellen Sidransky and Andrew Singleton (2024)

* v
* t
* e

Kavli Prize laureates

Astrophysics|

* Maarten Schmidt, Donald Lynden-Bell (2008)
* Jerry E. Nelson, Raymond N. Wilson, Roger Angel (2010)
* David C. Jewitt, Jane Luu, Michael E. Brown (2012)
* Alan Guth, Andrei Linde, Alexei Starobinsky (2014)
* Ronald Drever, Kip Thorne, Rainer Weiss (2016)
* Ewine van Dishoeck (2018)
* Andrew Fabian (2020)
* Roger Ulrich, Jørgen Christensen-Dalsgaard, Conny Aerts (2022)

Nanoscience|

* Louis E. Brus, Sumio Iijima (2008)
* Donald Eigler, Nadrian Seeman (2010)
* Mildred Dresselhaus (2012)
* Thomas Ebbesen, Stefan Hell, John Pendry (2014)
* Gerd Binnig, Christoph Gerber, Calvin Quate (2016)
* Emmanuelle Charpentier, Jennifer Doudna, Virginijus Šikšnys (2018)
* Harald Rose, Maximilian Haider, Knut Urban, Ondrej Krivanek (2020)
* Jacob Sagiv, Ralph G. Nuzzo, David L. Allara, George M. Whitesides (2022)

Neuroscience|

* Sten Grillner, Thomas Jessell, Pasko Rakic (2008)
* Richard Scheller, Thomas C. Südhof, James Rothman (2010)
* Cornelia Bargmann, Winfried Denk, Ann Graybiel (2012)
* Brenda Milner, John O'Keefe, Marcus Raichle (2014)
* Eve Marder, Michael Merzenich, Carla J. Shatz (2016)
* A. James Hudspeth, Robert Fettiplace, Christine Petit (2018)
* David Julius, Ardem Patapoutian (2020)
* Jean-Louis Mandel, Harry T. Orr, Christopher A. Walsh, Huda Zoghbi (2022)

Authority control databases

International|

* ISNI
* VIAF

National|

* Germany
* United States
* Netherlands
* Poland

Academics|

* CiNii
* Google Scholar
* ORCID
* Scopus

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