hydrogen dehydrogenase

Identifiers
EC no.| 1.12.1.2
CAS no.| 9027-05-8
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
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PMC| articles
PubMed| articles
NCBI| proteins

In enzymology, a hydrogen dehydrogenase (EC 1.12.1.2) is an enzyme that catalyzes the chemical reaction

H2 \+ NAD+ ⇌ {\displaystyle \rightleftharpoons } H+ \+ NADH

Thus, the two substrates of this enzyme are H2 and NAD+, whereas its two products are H+ and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NAD+ oxidoreductase. Other names in common use include H2:NAD+ oxidoreductase, NAD+-linked hydrogenase, bidirectional hydrogenase, and hydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism and methane metabolism. It has 6 cofactors: FAD, Iron, FMN, Flavin, Nickel, and Iron-sulfur.

## References

[edit]

* BONE DH, BERNSTEIN S, VISHNIAC W (1963). "Purification and some properties of different forms of hydrogen dehydrogenase". Biochim. Biophys. Acta. 67: 581–8\. doi:10.1016/0006-3002(63)91868-7. PMID 13968752.
* Schneider K, Schlegel HG (1976). "Purification and properties of soluble hydrogenase from Alcaligenes eutrophus H 16". Biochim. Biophys. Acta. 452 (1): 66–80\. doi:10.1016/0005-2744(76)90058-9. PMID 186126.

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Oxidoreductases: Acting on hydrogen as donor (EC 1.12)

1.12.1|

* Hydrogen dehydrogenase
* Hydrogen dehydrogenase (NADP+)
* Hydrogenase (NAD+, ferredoxin)

1.12.2|

* Cytochrome-c3 hydrogenase

1.12.5|

* Hydrogen:quinone oxidoreductase

1.12.7|

* Ferredoxin hydrogenase

1.10.98|

* Coenzyme F420 hydrogenase
* 5,10-Methenyltetrahydromethanopterin hydrogenase
* Methanosarcina-phenazine hydrogenase
* Sulfhydrogenase

1.10.99|

* Hydrogenase (acceptor)

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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