Iain McInnes

British rheumatologist (born 1964)

Iain McInnes

CBE FRCPE FRCPGlas FMedSci FRSE

Born|  (1964-10-19) 19 October 1964 (age 60)

Glasgow, Scotland[4]

Alma mater| University of Glasgow (BSc, MB ChB, PhD)[4]
Known for| Director of the Versus Arthritis Centre of Excellence for Inflammatory Arthritis
Awards| FRCPE
FRCPGlas
FRSE (2008)[1]
FMedSci (2012)[2]
CBE (2019)[3]
Scientific career
Fields| Rheumatology
Institutions| University of Glasgow
Thesis| Cytokine and nitric oxide production in inflammatory arthritis (1996)
Doctoral advisor| Prof. F.Y. Liew and Prof. Roger D. Sturrock
Website| www.gla.ac.uk/schools/infectionimmunity/staff/iainmcinnes/

Iain Blair McInnes FRCPE FRCPGlas FMedSci FRSE (born 19 October 1964) is a Scottish rheumatologist, Vice Principal and Head of the College of Medical, Veterinary and Life Sciences, Muirhead Chair of Medicine and Versus Arthritis Professor of Rheumatology at the University of Glasgow. His research has focused on inflammatory diseases, particularly rheumatoid arthritis and psoriatic arthritis.[5]

His work has focused on new approaches and treatments for inflammatory diseases. Over two decades, he has been involved in clinical trials and pathogenesis investigation programs in inflammatory arthritis at an international level. His research has also explored the biology of inflammatory cytokines in arthritis and other inflammatory diseases, as well as the mechanisms of co-morbidities in chronic diseases.[6]

## Research

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McInnes's research has investigated the role of cytokines and their inflammation amplification role in immune-mediated inflammatory disease (IMID) pathogenesis. His early work focused on defining the roles played by novel cytokines in driving inflammatory synovitis, including the effector functions of IL-15, IL-18, and IL-33 in rheumatoid (RA) and psoriatic arthritis (PsA) synovitis.[7][8][9] His studies also examined the cytokine-driven cellular interactions between T cells, macrophages, and synovial fibroblasts, particularly the role of non-antigen dependent amplification of synovial inflammation.[10][11]

Subsequently, his research identified several novel synovial cytokine amplificatory pathways involved in disease chronicity, such as PAR2 dependent matrix enzyme sensing,[12] and autoantibody to MICL mediated monocyte activation.[13] These studies have contributed to the understanding of the cellular and molecular mechanisms underlying inflammatory synovial disease.[14]

## Roles

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McInnes is Vice Principal and Head of the College of Medical, Veterinary and Life Sciences, Muirhead Chair of Medicine and Versus Arthritis Professor of Rheumatology at the University of Glasgow.[15]

He is past Chairman of the FOREUM (Foundation for European Rheumatology Research) Scientific Committee. From 2019 to 2021, he was President of EULAR,[16] the leading transnational society for rheumatology across Europe, during which time he founded the European Rheumatology Research Centre,[17] and established pan-European COVID-19 registries to define SARS-CoV-2 risk and vaccine efficacy across IMIDs. He chaired the UK Government’s Independent Advisory Group for strategies to support immune vulnerable patient groups during the COVID-19 pandemic.[18]

He is Director of the Versus Arthritis Centre of Excellence for Inflammatory Arthritis, led from Glasgow and including Universities of Oxford, Newcastle, and Birmingham.[19] He was Chief Investigator of the IMID-Bio-UK meta-consortium leading the UK effort to discover precision medicine tractable biomarkers for application in immune diseases.[20]

He is Associate Editor of Annals of the Rheumatic Diseases[21] and Editor in Chief of Firestein & Kelley's Textbook of Rheumatology.[22]

## Boards and committees

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* Chairperson of the NIHR Biorepository Governance Oversight Board (2021 - present)[23]
* MRC Experimental Medicine Board (Deputy Chair) (2020–2024)[24]
* Versus Arthritis Trustee (2021–present)[25]
* NHS Greater Glasgow & Clyde Health Board Member (2021–present)[26]
* Past-President of European Alliance of Rheumatology Associations (EULAR) (2019–2021)[27]
* Board member, Foreum Research Foundation (2023 – present)[28]
* Member of Lister Prize Committee (2021–present)[29]

## Awards and Honours

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McInnes was made of Commander of the Most Excellent Order of the British Empire (CBE) for services to medicine by Her Majesty the Queen in 2019.[30]

He is a Fellow of the Academy of Medical Sciences, a Fellow of the Royal Society of Edinburgh, and an Elected Member of Academia Europaea.[2][1][31] He is a Fellow of the Royal College of Physicians of Edinburgh and a Fellow of the Royal College of Physicians and Surgeons of Glasgow.[4]

He is the recipient of the Sir James Black Medal of the Royal Society of Edinburgh for "outstanding contribution to the field of immunology" (2017),[32] the Heberden Medal of the British Society for Rheumatology (2018), and the Carol-Nachman Prize for Rheumatology in Germany (2019).[33] Other awards include the Royal Philosophical Society of Glasgow's Thomas Graham Medal (2022),[34] Tenovus Scotland's Lady Margaret McLellan Award (2016),[35] the Laurentian Society’s JL Demers Award in Canada (2017),[36] and the British Society for Rheumatology’s Michael Mason Prize (2001).[37]

## References

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1. ^ a b "Professor Iain McInnes". Royal Society of Edinburgh.
2. ^ a b "Professor Iain McInnes - The Academy of Medical Sciences".
3. ^ "Who are the Scots on the Honours List?". BBC News. 29 December 2018.
4. ^ a b c "MCINNES, Prof. Iain Blair". Who's Who 2023, A & C Black, an Imprint of Bloomsbury Publishing PLC, 2023; Online Edn, Oxford University Press. doi:10.1093/ww/9780199540884.013.U267837.(subscription may be required or content may be available in libraries)
5. ^ "University of Glasgow - Research - Glasgow Research Beacons - Precision Medicine & Chronic Diseases - Professor Iain McInnes". www.gla.ac.uk.
6. ^ "Professor Iain McInnes". acmedsci.ac.uk.
7. ^ McInnes, I. B.; Leung, B. P.; Sturrock, R. D.; Field, M.; Liew, F. Y. (1997). "Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis". Nature Medicine. 3 (2): 189–195\. doi:10.1038/nm0297-189. PMID 9018238.
8. ^ Gracie, J. A.; Forsey, R. J.; Chan, W. L.; Gilmour, A.; Leung, B. P.; Greer, M. R.; Kennedy, K.; Carter, R.; Wei, X. Q.; Xu, D.; Field, M.; Foulis, A.; Liew, F. Y.; McInnes, I. B. (1999). "A proinflammatory role for IL-18 in rheumatoid arthritis". The Journal of Clinical Investigation. 104 (10): 1393–1701\. doi:10.1172/JCI7317. PMC 409841. PMID 10562301.
9. ^ Xu, D.; Jiang, H. R.; Li, Y.; Pushparaj, P. N.; Kurowska-Stolarska, M.; Leung, B. P.; Mu, R.; Tay, H. K.; McKenzie, A. N.; McInnes, I. B.; Melendez, A. J.; Liew, F. Y. (2010). "IL-33 exacerbates autoantibody-induced arthritis". Journal of Immunology. 184 (5): 2620–2626\. doi:10.4049/jimmunol.0902685. PMID 20139274.
10. ^ McInnes, I. B.; Leung, B. P.; Liew, F. Y. (2000). "Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells". Arthritis Research. 2 (5): 374–378\. doi:10.1186/ar115. PMC 130139. PMID 11094451.
11. ^ McInnes, Iain B.; Schett, Georg (2007). "Cytokines in the pathogenesis of rheumatoid arthritis". Nature Reviews Immunology. 7 (6): 429–442\. doi:10.1038/nri2094. PMID 17525752.
12. ^ Crilly, A.; Burns, E.; Nickdel, M. B.; Lockhart, J. C.; Perry, M. E.; Ferrell, P. W.; Baxter, D.; Dale, J.; Dunning, L.; Wilson, H.; Nijjar, J. S.; Gracie, J. A.; Ferrell, W. R.; McInnes, I. B. (2012). "PAR(2) expression in peripheral blood monocytes of patients with rheumatoid arthritis". Annals of the Rheumatic Diseases. 71 (6): 1049–1054\. doi:10.1136/annrheumdis-2011-200703. PMC 4861243. PMID 22294633.
13. ^ Redelinghuys, Pierre; Whitehead, Lauren; Augello, Andrea; Drummond, Rebecca A.; Levesque, Jean-Michel; Vautier, Simon; Reid, Delyth M.; Kerscher, Bernhard; Taylor, Julie A.; Nigrovic, Peter A.; Wright, John; Murray, Graeme I.; Willment, Janet A.; Hocking, Lynne J.; Fernandes, Maria J G.; De Bari, Cosimo; McInnes, Iain B.; Brown, Gordon D. (2016). "MICL controls inflammation in rheumatoid arthritis". Annals of the Rheumatic Diseases. 75 (7): 1386–1391\. doi:10.1136/annrheumdis-2014-206644. PMC 4941174. PMID 26275430.
14. ^ "I McInnes".
15. ^ "AAD Reading Room | Iain McInnes, MD, on the Latest Findings on Bimekizumab for Psoriatic Arthritis | MedPage Today".
16. ^ "EULAR Message from the President, Professor Iain McInnes | Türkiye Romatizma Araştırma ve Savaş Derneği".
17. ^ Reuter, Katja; Haupt, Carina; Molto, Anna; Cope, Andrew; Van Vollenhoven, Ronald F.; Elewaut, Dirk; Lories, Rik; McInnes, Iain B. (2022). "Levelling the playing field of RMD research across Europe to address patients' needs: The emerging EULAR Research Centre". RMD Open. 8 (2): e002456. doi:10.1136/rmdopen-2022-002456. PMC 9207999. PMID 35714997.
18. ^ "Defining the highest-risk clinical subgroups upon community infection with SARS-CoV-2 when considering the use of neutralising monoclonal antibodies (NMABs) and antiviral drugs: Independent advisory group report".
19. ^ "Determined doctor's quest is inspired by patients' battles". 24 February 2014.
20. ^ "Universities to create world's largest inflammatory disease biobank".
21. ^ ""Professor Iain B McInnes - Eminent Consortium - UCL - University College London"". 25 February 2019.
22. ^ Firestein, Gary S.; Kelley, William N. (10 April 2024). "Kelley's Textbook of Rheumatology - ScienceDirect". Elsevier Health Sciences. ISBN 978-1-4377-1738-9.
23. ^ "Oversight Board". bioresource.nihr.ac.uk.
24. ^ "Experimental Medicine Panel". www.ukri.org.
25. ^ "Trustees and Co-optees". Versus Arthritis.
26. ^ "NHS Board Archives - Page 4 of 5 - NHSGGC".
27. ^ "EULAR 2021". www.esanum.fr.
28. ^ "FOREUM – Operational structure". www.foreum.org.
29. ^ "Scientific Committee".
30. ^ "Trio honoured for work at University of Glasgow". 29 December 2018.
31. ^ "Academy of Europe: McInnes Iain".
32. ^ "RSE Sir James Black Medal". Royal Society of Edinburgh.
33. ^ "UofG Professor awarded one of Germany's most prestigious medical prizes". www.gla.ac.uk.
34. ^ "Members' Newsletter Royal Philosophical Society" (PDF).
35. ^ "Tenovus Scotland".
36. ^ "Awards".
37. ^ Plenary Session (including the Michael Mason Prize winner) (Abstracts 179-185), Rheumatology, Volume 40, Issue suppl_1, April 2001, Pages 63–65

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