Intraepithelial neoplasia

High grade anal intraepithelial neoplasia. Progression of pancreatic intraepithelial neoplasia, including mutations.[1] Cervical intraepithelial neoplasia (CIN), spanning a bit more than 2/3 of the thickness of the cervical epithelium.

Intraepithelial neoplasia (IEN) is the development of a benign neoplasia or high-grade dysplasia in an epithelium. The exact dividing line between dysplasia and neoplasia has been very difficult to draw throughout the era of medical science. It varies between persons. In the localizations shown below, the term intraepithelial neoplasia is used to describe more accurately what was historically referred to as epithelial dysplasia. IEN is not cancer, but it is associated with higher risk for developing cancer in future. It is thus sometimes a precancerous condition.

## Localizations

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Localization | Usual acronym

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anal intraepithelial neoplasia | AIN
biliary intraepithelial neoplasia | BILIN
cervical intraepithelial neoplasia | CIN
endometrial intraepithelial neoplasia | EIN
esophageal intraepithelial neoplasia[2] | EIEN
gastrointestinal intraepithelial neoplasia[3] | GIN
pancreatic intraepithelial neoplasia | PanIN
penile intraepithelial neoplasia | PEIN
prostatic intraepithelial neoplasia | PIN
vaginal intraepithelial neoplasia | VIN
vulvar intraepithelial neoplasia | VIN

## References

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1. ^ Hackeng WM, Hruban RH, Offerhaus GJ, Brosens LA (2016). "Surgical and molecular pathology of pancreatic neoplasms". Diagn Pathol. 11 (1): 47. doi:10.1186/s13000-016-0497-z. PMC 4897815. PMID 27267993.`{{cite journal}}`: CS1 maint: multiple names: authors list (link)
\- "This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)"
\- Image title and optimization: Mikael Häggström, M.D.
2. ^ Shimizu, Michio; Nagata, Koji; Yamaguchi, Hiroshi; Kita, Hiroto (February 2009). "Squamous intraepithelial neoplasia of the esophagus: past, present, and future". Journal of Gastroenterology. 44 (2): 103–112\. doi:10.1007/s00535-008-2298-y. ISSN 0944-1174. PMID 19214671.
3. ^ Schlemper, RJ; et al. (2000). "The Vienna classification of gastrointestinal epithelial neoplasia". Gut. 47 (2): 251–5\. doi:10.1136/gut.47.2.251. PMC 1728018. PMID 10896917.

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